Article
Multidisciplinary Sciences
Isak W. Tengesdal, Dinoop R. Menon, Douglas G. Osborne, Charles P. Neff, Nicholas E. Powers, Fabia Gamboni, Adolfo G. Mauro, Angelo D'Alessandro, Davide Stefanoni, Morkos A. Henen, Taylor S. Mills, Dennis M. De Graaf, Tania Azam, Beat Vogeli, Brent E. Palmer, Eric M. Pietras, James DeGregori, Aik-Choon Tan, Leo A. B. Joosten, Mayumi Fujita, Charles A. Dinarello, Carlo Marchetti
Summary: NLRP3 inflammasome activation in melanoma promotes tumor growth and progression while suppressing immune response. Inhibiting NLRP3 can reduce the expansion of MDSCs, enhance antitumor immunity, and slow down tumor growth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Enza Torre, Giulia Pinton, Grazia Lombardi, Silvia Fallarini
Summary: This study investigates the suppressive effects of melanoma cell lines on the functions of invariant natural killer T (iNKT) cells. It demonstrates that co-culture with melanoma cell lines significantly impairs the proliferation and cytotoxic capability of iNKT cells. Additionally, the up-regulation of IDO1 expression and PGE2 production by melanoma cells is identified as the key mechanism underlying the suppression of iNKT cell activation and functions.
Article
Oncology
Ville Suhonen, Jaana Rummukainen, Hanna Siiskonen, Arto Mannermaa, Ilkka T. Harvima
Summary: The study analyzed 543 melanoma samples collected in Eastern Finland from 2000-2013, finding a relatively high age at diagnosis for malignant melanoma and a significant increase in MM type during 2000-2013. Metastasis was found to be correlated with factors such as immunosuppression, male gender, Clark level, Breslow thickness, and ulceration.
Article
Chemistry, Physical
Huan Yan, Zhanyan Liu, Guibin Lin, Fei Gu, Yan Liu, Yuxiao Xu, Xueli Kuang, Yuan Zhang
Summary: This study describes a strategy to kill tumor cells and inhibit the expansion and suppressive function of myeloid cells through the systemic delivery of gemcitabine monophosphate (GMP) and STAT3 siRNA (siSTAT3) using nanotechnology. Compared to the control and monotherapy groups, combined GMP and siSTAT3 nanoparticles effectively induced tumor cell death, downregulated pro-tumor signaling pathways and immunosuppressive mediators, eliminated MDSCs, enhanced T cell effector functions, and led to superior therapeutic efficacy in a mouse melanoma model.
Article
Immunology
Vera Petrova, Christopher Groth, Rebekka Bitsch, Ihor Arkhypov, Sonja C. S. Simon, Svetlana Hetjens, Verena Mueller, Jochen Utikal, Viktor Umansky
Summary: This study investigated the dynamic changes in immunosuppressive pattern and activity of myeloid-derived suppressor cells (MDSC) in melanoma patients treated with immune checkpoint inhibitors (ICI). It was found that non-responders had higher frequency and immunosuppressive activity of MDSC compared to responders. Additionally, non-responders had higher concentrations of IL-6 and IL-8 before therapy and after the first ICI application compared to responders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Wenzhe Yang, Xue Pan, Peng Zhang, Xue Yang, Huashi Guan, Huan Dou, Qian Lu
Summary: A dual-administration paradigm involving transdermal and intravenous delivery was developed to reverse the hypoxic and immunosuppressive tumor microenvironment in the treatment of malignant melanoma. The Ato/cabo@PEG-TK-PLGA nanoparticles successfully penetrated the tumor and released atovaquone and cabozantinib, which reversed the hypoxic and immunosuppressive microenvironment, respectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Juliano T. Freitas, Jesus Lopez, Claudia Llorian, Mariana Boroni, Lidia Kos
Summary: Endothelin receptor B signaling plays a crucial role in the melanoma microenvironment, mediating immunosuppression that leads to tumor immune evasion. The presence of regulatory T cells and dendritic cells is significantly higher in K5-Edn3 tumors compared to control tumors. In vitro, Edn3 not only promotes Treg proliferation but also upregulates FOXP3 expression.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Satu Salmi, Kaisla Halinen, Anton Lin, Sanna Suikkanen, Otto Jokelainen, Eija Rahunen, Hanna Siiskonen, Sanna Pasonen-Seppanen
Summary: In melanoma, CD8+ and GrB+ lymphocytes were found to be more abundant in pT4 melanomas and lymph node metastases compared to primaries. A low GrB/CD8 ratio was associated with better recurrence-free survival in primary melanomas, suggesting that GrB+ lymphocytes may represent activated immunosuppressive lymphocytes.
Article
Oncology
Linda Ziani, Stephanie Buart, Salem Chouaib, Jerome Thiery
Summary: This study reveals that hypoxia increases the expression and secretion of immunosuppressive factors by melanoma-associated fibroblasts, with hypoxic CAF secretome exerting a more profound effect on T cell-mediated cytotoxicity than normoxic counterpart. The crosstalk between hypoxia and CAFs may be an important determinant in the complex immunosuppressive tumor microenvironment.
Article
Gastroenterology & Hepatology
Daniela Pugliese, Giuseppe Privitera, Federica Crispino, Nicolo Mezzina, Fabiana Castiglione, Gionata Fiorino, Lucrezia Laterza, Anna Viola, Lorenzo Bertani, Flavio Caprioli, Maria Cappello, Brigida Barberio, Chiara Ricci, Paola Balestrieri, Marco Daperno, Dario Pluchino, Fernando Rizzello, Maria Lia Scribano, Renato Sablich, Luca Pastorelli, Francesco Manguso, Angela Variola, Antonio Di Sario, Laurino Grossi, Alessandro Armuzzi
Summary: The study included 198 elderly (108 UC, 90 CD) and 396 matched nonelderly patients (205 UC, 191 CD). Nonelderly UC patients had a significantly higher persistence on vedolizumab compared to elderly patients. No significant difference in effectiveness was observed between elderly and nonelderly CD patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Oncology
Yingyue Liu, Xiangxiang Zhou, Xin Wang
Summary: B-cell lymphoma, a hematological malignancy with high clinical and biological heterogeneity, involves complex interactions between tumor cells and the tumor microenvironment. Exploring the tumor microenvironment provides new insights for cancer therapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Alicja Rzepecka, Dariusz Jagielski, Anna Cywinska, Rafal Sapierzynski, Magdalena Zmigrodzka, Olga Witkowska-Pilaszewicz, Anna Winnicka
Summary: This study evaluated the changes in MHCII expression in monocytes of dogs with lymphoma, and found an increase in the percentage of MHCII- monocytes regardless of treatment. However, only in dogs that had received glucocorticoids, changes in the proportion of MHCII+ and MHCII- monocytes were reflected by the changes in the number of MHCII- monocytes in the blood, which was significantly higher. These results suggest that evaluating MHCII expression changes in monocytes could be helpful in diagnosing lymphoma, monitoring treatment, or assessing immune status in dogs.
Review
Gastroenterology & Hepatology
James L. Alexander, Gordon W. Moran, Daniel R. Gaya, Tim Raine, Ailsa Hart, Nicholas A. Kennedy, James O. Lindsay, Jonathan MacDonald, Jonathan P. Segal, Shaji Sebastian, Christian P. Selinger, Miles Parkes, Philip J. Smith, Anjan Dhar, Sreedhar Subramanian, Ramesh Arasaradnam, Christopher A. Lamb, Tariq Ahmad, Charlie W. Lees, Liz Dobson, Ruth Wakeman, Tariq H. Iqbal, Ian Arnott, Nick Powell
Summary: SARS-CoV-2 vaccination in patients with IBD is supported due to anticipated low risks, despite some concerns that protective immune responses may be diminished in certain patients. Further research is needed to address vaccine hesitancy, the impact of immunosuppression, and the search for predictive biomarkers of vaccine success.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Audry Fernandez, Wentao Deng, Sarah L. McLaughlin, Anika C. Pirkey, Stephanie L. Rellick, Atefeh Razazan, David J. Klinke
Summary: Cell Communication Network factor 4 (CCN4/WISP1) is a matricellular protein secreted by cancer cells that promotes metastasis by inducing the epithelial-mesenchymal transition. Knocking out CCN4 reduces tumor growth and increases tumor-infiltrating leukocytes, natural killer cells, and CD8(+) T cells in immunocompetent mice. CCN4 suppresses IFN-gamma release by CD8(+) T cells and enhances tumor secretion of chemokines that attract myeloid-derived suppressor cells. CCN4 KO potentiates the anti-tumor effect of immune checkpoint blockade therapy.
Article
Hematology
M. K. Gandhi, T. Hoang, S. C. Law, S. Brosda, K. O'Rourke, J. W. D. Tobin, F. Vari, V Murigneux, L. Fink, J. Gunawardana, C. Gould, H. Oey, K. Bednarska, S. Delecluse, R. U. Trappe, L. Merida de Long, M. B. Sabdia, G. Bhagat, G. Hapgood, E. Blyth, L. Clancy, J. Wight, E. Hawkes, L. M. Rimsza, A. Maguire, K. Bojarczuk, B. Chapuy, C. Keane
Summary: Primary central nervous system lymphoma (PCNSL) is a rare brain lymphoma that has distinct immunobiological differences between EBV-associated PCNSL in immunosuppressed individuals and EBV-negative PCNSL. These differences are evident in cellular mutations and immune environments.
Article
Gastroenterology & Hepatology
Ravy K. Vajravelu, Jennifer M. Kolb, Shivani U. Thanawala, Frank Scott, Samuel Han, Amit G. Singal, Gary W. Falk, David A. Katzka, Sachin Wani
Summary: This study used data from large commercial and Medicare Advantage health plans in the United States to assess and improve the effectiveness of Barrett's esophagus (BE) screening and surveillance. The results showed that two-thirds of esophageal adenocarcinomas (EACs) were diagnosed at the time of BE diagnosis and post-endoscopy esophageal adenocarcinoma accounted for 14% of these EACs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Brad D. Constant, Edwin F. de Zoeten, Jason P. Weinman, Lindsey Albenberg, Frank Scott
Summary: This study aimed to describe the multidisciplinary management of pediatric patients with internally penetrating Crohn's Disease complications and explore the effectiveness and safety of Anti-TNF therapy prior to complication resolution. The study results suggest that initiating Anti-TNF therapy before complication resolution may be a safe and effective strategy to improve clinical outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Frank Scott, Orna Ehrlich, Dallas Wood, Catherine Viator, Carrie Rains, Lisa DiMartino, Jill McArdle, Gabrielle Adams, Lara Barkoff, Jennifer Caudle, Jianfeng Cheng, Jami Kinnucan, Kimberly Persley, Jennifer Sariego, Samir Shah, Caren Heller, David T. Rubin
Summary: This study developed a care pathway for patients with inflammatory bowel disease (IBD) to prompt appropriate consultation with IBD specialists. The pathway included major and minor criteria identified through a literature review and expert panel discussions. Implementation barriers and facilitators were also assessed. The care pathway provides key criteria for triaging IBD patients and future research is needed to validate its effectiveness.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
John P. Haydek, Frank I. Scott
Summary: This article is connected to the papers by Saifuddin et al. To access these papers, visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Timothy Yen, Blake Jones, Jeannine M. Espinoza, Sarguni Singh, Jonathan Pell, Anna Duloy, Sachin Wani, Frank I. Scott, Swati G. Patel
Summary: This study aimed to optimize and standardize the process and clinical outcomes in upper GI bleeding (UGIB)-related care. The use of electronic health record note templates improved adherence to guidelines and standardized medication prescriptions and follow-up procedures, resulting in improved clinical outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Surgery
Eric Swei, Laura Helmkamp, Jason Samuels, Jonathan Schoen, Frank I. Scott, Sachin Wani, Shelby Sullivan
Summary: Recent studies have shown that sleeve gastrectomy (SG) may lead to the development of Barrett esophagus (BE) even without symptoms of gastroesophageal reflux disease (GERD). This study aimed to assess the rates of upper endoscopy and incidence of new BE diagnoses in patients undergoing SG. The results revealed that patients who underwent SG had a higher risk of developing postoperative esophagitis or BE compared to the general population.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
John Galatowitsch, John P. Haydek, Waseem Ahmed, Blair Fennimore, Debbie Cheng, Calen A. Steiner, Benjamin Click, Mark E. Gerich, Alexis Oonk, Frank I. Scott
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Sarah Beilke, Robert T. Simril, Frank I. Scott, Eric Swei
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Mohamed Noureldin, Jeffrey Berinstein, Frank I. Scott, Peter D. Higgins, Ryan Stidham, Shirley Cohen-Mekelburg, Jason K. Hou, Akbar K. Waljee
Meeting Abstract
Gastroenterology & Hepatology
Frank I. Scott, Anita Afzali, Parambir Dulai, Mei Lu, Ninfa Candela, Tao Fan, Sabyasachi Ghosh, James D. Lewis
Meeting Abstract
Gastroenterology & Hepatology
Paul Hobbs, Frank I. Scott, Alice Gray, Paul Menard-Katcher
Meeting Abstract
Gastroenterology & Hepatology
Jennifer M. Kolb, Mindy L. Chen, Anna Tavakkoli, Jazmyne Gallegos, Jack O'Hara, Wyatt Tarter, Camille J. Hochheimer, Bryan Golubski, Noa G. Kopplin, Lilly A. Hennessey, Anita Kalluri, Shalika Devireddy, Frank I. Scott, Gary W. Falk, Amit G. Singal, Ravy K. Vajravelu, Sachin B. Wani
Meeting Abstract
Gastroenterology & Hepatology
Amr Arar, Frank I. Scott, Kelli Delay, Paul Menard-Katcher
Meeting Abstract
Gastroenterology & Hepatology
Jonathon Cahoon, John P. Haydek, Swati Patel, Mark E. Gerich, Blair Fennimore, Alexis Oonk, Waseem Ahmed, Calen A. Steiner, Debbie Cheng, Brad D. Constant, Edward L. Barnes, James D. Lewis, Frank I. Scott
Meeting Abstract
Gastroenterology & Hepatology
Frank Scott, Anita Afzali, Parambir Dulai, Mei Lu, Ninfa Candela, Tao Fan, Tito Ghosh, James Lewis