Kaempferol 3‐O ‐gentiobioside, an ALK5 inhibitor, affects the proliferation, migration, and invasion of tumor cells via blockade of the TGF ‐β/ ALK5 /Smad signaling pathway

Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐ k B pathway and modulating oxidative stress, cell cycle, and fibrogenesis

(2021) Kadry M. Sadek et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

TGFβ family signaling and development

(2021) Shunji Jia et al.   DEVELOPMENT

Studies in lung cancer cytokine proteomics: a review

(2021) Hanie Abolfathi et al.   Expert Review of Proteomics

ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders

(2021) Jia Li et al.   JOURNAL OF CLINICAL INVESTIGATION

MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer

(2021) Ran-Ran Ma et al.   ONCOGENE

Relapsed multiple myeloma demonstrates distinct patterns of immune microenvironment and malignant cell-mediated immunosuppression

(2021) Alissa Visram et al.   Blood Cancer Journal

Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

(2021) Mana Taki et al.   CLINICAL CANCER RESEARCH

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

(2021) Yoko Katsuno et al.   DEVELOPMENTAL CELL

TGF-β signaling in Liver, Pancreas, and Gastrointestinal Diseases and Cancer

(2021) Nancy R. Gough et al.   GASTROENTEROLOGY

Novel therapies emerging in oncology to target the TGF-β pathway

(2021) Byung-Gyu Kim et al.   Journal of Hematology & Oncology

Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?

(2021) Mark P. Ward et al.   Molecular Cancer

In vitro Assessment of Green Polyhydroxybutyrate/Chitosan Blend Loaded with Kaempferol Nanocrystals as a Potential Dressing for Infected Wounds

(2021) Marian Rofeal et al.   NANOTECHNOLOGY

Garcimultiflorone K from Garcinia multiflora attenuates hepatocellular carcinoma metastasis by suppressing transforming growth factor-β signaling

(2021) Shu-Fang Huang et al.   PHYTOMEDICINE

Effects of administration of probiotic lactobacilli on immunity conferred by the herpesvirus of turkeys vaccine against challenge with a very virulent Marek’s disease virus in chickens

(2021) Jegarubee Bavananthasivam et al.   VACCINE

Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria

(2021) Rajkishor Nishad et al.   Cell Death & Disease

Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer

(2021) Julienne L. Carstens et al.   Cell Reports

A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2

(2021) Youyuan Deng et al.   Cancers

Overcoming the UCB HSCs –Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways

(2021) Alireza Shokouhifar et al.   Cancer Cell International

Transforming growth factor–β in tissue fibrosis

(2020) Nikolaos G. Frangogiannis   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical development of therapies targeting TGFβ: current knowledge and future perspectives.

(2020) D. Ciardiello et al.   ANNALS OF ONCOLOGY

Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis

(2020) Shixia Bu et al.   Cell Death & Disease

WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer

(2020) Wei Wang et al.   Oncogenesis

Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5

(2019) Xiaolu Ye et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study

(2019) Su Young Jung et al.   INVESTIGATIONAL NEW DRUGS

Kaempferol attenuates liver fibrosis by inhibiting activin receptor–like kinase 5

(2019) Taifu Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phase 2 Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes

(2019) Valeria Santini et al.   CLINICAL CANCER RESEARCH

Platyconic Acid A, Platycodi Radix-Derived Saponin, Suppresses TGF-β1-Induced Activation of Hepatic Stellate Cells via Blocking SMAD and Activating the PPARγ Signaling Pathway

(2019) Jae Ho Choi et al.   Cells

OUP accepted manuscript

(2018)   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

(2016) Peter Giovannini et al.   JOURNAL OF ETHNOPHARMACOLOGY

Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway

(2016) Yifan Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

(2013) Jeong-Hwan Yoon et al.   EMBO Molecular Medicine

Antidiabetic components ofCassia alataleaves: Identification through α-glucosidase inhibition studies

(2012) George Kadakasseril Varghese et al.   PHARMACEUTICAL BIOLOGY

Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term T RI/II Kinase Inhibition with LY2109761

(2011) E. C. Connolly et al.   CANCER RESEARCH

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

VEGF and inhibitors of TGF  type-I receptor kinase synergistically promote blood-vessel formation by inducing  5-integrin expression

(2009) Z. Liu et al.   JOURNAL OF CELL SCIENCE