Article
Oncology
Yang Li, Yuxin Zhong, Quan Xu, Zhikai Zhu, Yantao Tian
Summary: This study demonstrates that different proportions of signet ring cells in GSRC can impact the survival of patients, with those in the high proportion group having a significantly higher overall survival rate compared to those in the low proportion group. Further clinical studies are needed to develop appropriate treatment strategies for GSRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Cheng-liang Chen, Di-xin Xue, Ha-ha Chen, Mei-zhen Liang, Dao-zhe Lin, Ming Yu, Ji-xian Chen, Wei-li Wu
Summary: Nomograms were developed to predict overall survival (OS) and cancer-specific survival (CSS) in patients with signet-ring cell carcinoma (SRCC) of the stomach. The nomograms included various clinical variables and showed good predictive ability in calibration plots, ROC curves, and DCA. The new model was found to be more useful than the TNM staging system.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Kazunori Takahashi, Katsutoshi Shoda, Koichi Takiguchi, Yudai Higuchi, Koichi Matsuoka, Takashi Nakayama, Ryo Saito, Suguru Maruyama, Yuki Nakata, Shinji Furuya, Kensuke Shiraishi, Hidenori Akaike, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa
Summary: Differentiated cancer-associated fibroblasts with high ACTA2 and PDPN expression levels significantly promoted gastric cancer cell migration, invasion, and proliferation. The subtype of cancer-associated fibroblasts with ACTA2 and PDPN expression was found to be an independent prognostic factor for gastric cancer patients undergoing surgery, along with lymph node metastasis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Chi Zhang, Ran Liu, Wei-Han Zhang, Xin-Zu Chen, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Zhi-Xin Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study found that patients with signet ring cell gastric cancer are typically younger and more commonly female compared to those with non-signet ring cell gastric cancer. For early stage signet ring cell gastric cancer patients, they have a lower lymph nodes metastasis rate and comparable prognosis with non-signet ring cell cancers; however, in advanced tumor stage, signet ring cell gastric cancer has a significantly worse prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Jia-Bin Wang, Man-Qiang Lin, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: This study evaluated the prognostic impact of body mass index (BMI) on signet ring cell gastric carcinoma (SRC) patients. The results showed that as BMI decreases, SRC has a worse prognostic impact. Different BMI levels can lead to differing prognosis of SRC compared with tubular adenocarcinoma.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Oncology
Shuai Zhao, Ling Lv, Kai Zheng, Yu Tian, Jian-Chun Zheng, Cheng-Gang Jiang
Summary: The prognosis of SRC is better at early stage compared to other types of gastric cancer, while it is relatively poorer at advanced stage.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Chen, Huajun Cai, Kui Chen, Xing Liu, Weizhong Jiang, Shoufeng Li, Yiyi Zhang, Zhifen Chen, Guoxian Guan
Summary: This study analyzed the prognosis of patients with different signet-ring cell composition and established a prediction model. The results showed that the ratio of signet-ring cell component was not an independent prognostic factor for overall survival (OS), and patients with less than 50% signet-ring cell component should receive the same clinical attention. A predictive nomogram based on five independent prognostic factors was developed, which showed better performance than the 7th American Joint Committee on Cancer (AJCC) staging system.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Luigina Graziosi, Elisabetta Marino, Nicola Natalizi, Annibale Donini
Summary: This study investigates the clinical pathological characteristics and survival prognostic significance of signet ring cell components in patients affected by gastric cancer. The incidence of signet ring cell carcinoma is increasing over time. The prognosis of signet ring cell carcinoma is better in early gastric cancer, but recurrence occurs more frequently in these patients. Factors such as preoperative serum albumin level, surgical resection, lymphadenectomy level, and pathological stage are independent factors affecting overall survival. Radical surgical procedures and adequate lymphadenectomy should be advocated to improve patient survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
He-Li Liu, Xiang Feng, Mi-Mi Tang, Hai-Yan Zhou, Huan Peng, Jie Ge, Ting Liu
Summary: The study evaluated the predictive accuracy of preoperative LMR for prognosis of signet ring gastric cancer. The results showed that a low preoperative LMR level predicts poor prognosis in signet ring gastric cancer patients.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Yubo Ma, Yi Wang, Can Hu, Mengli Zi, Jinxia Chen, Mengxuan Cao, Li Yuan, Litao Yang, Yian Du
Summary: This study found that the percentage of signet-ring cells (SRCs) is an independent prognostic indicator for overall survival (OS) in advanced gastric cancer. The study also developed a prognostic nomogram for assessing the prognosis of gastric signet-ring cell carcinoma (GSRCC) patients.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Oncology
Yangkun Wang, Yingying Li, Bin Wang, Dongmei Ran, Chaoya Zhu, Ping Li, Bo Jiang, Sunan Wang
Summary: This study investigated the early onset, development, and histological features of gastric signet-ring cell carcinoma (SRCC). The results showed that gastric mucosa infection, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in specific areas of the stomach. SRCC grows infiltratively and can differentiate into various types of adenocarcinoma with signet-ring cell differentiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Franco Roviello, Luigi Marano, Maria Raffaella Ambrosio, Luca Resca, Alessia D'Ignazio, Federica Petrelli, Roberto Petrioli, Maurizio Costantini, Karol Polom, Raffaele Macchiarelli, Ivano Biviano, Daniele Marrelli
Summary: This study evaluated the impact of the percentage of signet ring cells (SRC) on the clinical, pathological, and prognostic features of poorly cohesive gastric cancer. The results showed that the percentage of SRCs is inversely related to tumor aggressiveness, and SRC pattern serves as an independent predictor of survival.
Article
Oncology
Shuairan Zhang, Yang Liu, Zihan Jiao, Zenan Li, Jin Wang, Ce Li, Xiujuan Qu, Ling Xu
Summary: This study identified seven independent prognostic factors of GSRCC and established corresponding nomogram models to help clinicians predict survival, showing good predictive value in comparison to the traditional AJCC staging system.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yu Yang, Yoshimasa Akashi, Osamu Shimomura, Hiroaki Tateno, Sayoko Saito, Keiko Hiemori, Yoshihiro Miyazaki, Tomoaki Furuta, Daichi Kitaguchi, Yukihito Kuroda, Louphrasitthiphol Pakavarin, Tatsuya Oda
Summary: Specific glycan profiles in SRC cells were reported, showing reduced alpha 2-6-linked sialic acids. Additionally, a targeted therapy using the rBC2LCN lectin might be applicable as an alternative treatment option for patients with SRC.
Article
Oncology
In-Hye Ham, Lei Wang, Dagyeong Lee, Jongsu Woo, Tae Hoon Kim, Hye Young Jeong, Hye Jeong Oh, Kyeong Sook Choi, Tae-Min Kim, Hoon Hur
Summary: This study aimed to investigate the role of the JAK/STAT3 signaling pathway in the chemoresistance of gastric cancer induced by cancer-associated fibroblasts (CAF). The results showed that CAFs increased the resistance of gastric cancer cells to chemotherapy, and this was associated with the activation of the JAK/STAT3 pathway. However, the natural product curcumin was found to inhibit the activation of this pathway and sensitize the cancer cells to chemotherapy. These findings suggest that targeting the JAK/STAT3 pathway may be a potential strategy to overcome chemoresistance in gastric cancer, and curcumin could be a promising natural compound for this purpose.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Seo-Gyu Park, Mi-Jung Ji, In-Hye Ham, Yoon-Hee Shin, Su-Min Lee, Chang Hoon Lee, Eunjung Kim, Hoon Hur, Hyun-Mee Park, Jae-Young Kim
Summary: This study found that under hypoxic conditions, gastric cancer cells exhibited increased migration ability, which was associated with the reduced expression of COL4A2 in CAFs secretome.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Jeong Ho Song, Sang-Yong Son, Hoon Hur, Sang-Uk Han
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Surgery
Dong Jin Kim, Woo Jin Hyung, Young-Kyu Park, Hyuk-Joon Lee, Ji Yeong An, Hyoung-Il Kim, Hyung-Ho Kim, Seung Wan Ryu, Hoon Hur, Min-Chan Kim, Seong-Ho Kong, Jin-Jo Kim, Do Joong Park, Keun Won Ryu, Young Woo Kim, Jong Won Kim, Joo-Ho Lee, Han-Kwang Yang, Sang-Uk Han, Wook Kim
Summary: This study demonstrated the accuracy of preoperative staging for locally advanced gastric cancer through a large-scale randomized clinical trial, and identified risk factors for staging underestimation. It provides important insights for treatment selection and clinical trial design in gastric cancer.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Medicinal
Shingpan Chan, Yunong Zhang, Jie Wang, Qiuchun Yu, Xia Peng, Jian Zou, Licheng Zhou, Li Tan, Yunxin Duan, Yang Zhou, Hoon Hur, Jing Ai, Zhen Wang, Xiaomei Ren, Zhang Zhang, Ke Ding
Summary: The study describes the discovery of 3-aminopyrazole derivatives as potent and selective AXL kinase inhibitors. One representative compound, 6li, showed strong inhibitory activity against AXL enzymatic activity and demonstrated significant antitumor efficacy in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
In Kyong Yi, Jin-Soo Kim, Hoon Hur, Do-Gyun Han, Ji Eun Kim
Summary: This study investigated the effects of deep neuromuscular block (NMB) on SPI-guided remifentanil administration in laparoscopic herniorrhaphy. The results showed that deep NMB reduced the requirement of remifentanil compared to moderate NMB and led to a shorter duration of post-anesthesia care unit stay.
SCIENTIFIC REPORTS
(2022)
Letter
Surgery
Sang-Yong Son, Hoon Hur, Sang-Uk Han
Review
Oncology
Jeong Ho Song, Yeonkyoung Lee, Jaesung Heo, Sang-Yong Son, Hoon Hur, Sang-Uk Han
Summary: With advancements in treatment and detection techniques, the survival rate of gastric cancer patients is improving, but the risk of secondary primary cancer is also increasing. Evidence-based screening is needed to monitor and prevent new primary cancer in gastric cancer survivors. The characteristics and prognosis of secondary primary cancer are of great interest to these survivors.
Article
Geriatrics & Gerontology
Heewon Chung, Yousun Ko, In-Seob Lee, Hoon Hur, Jimi Huh, Sang-Uk Han, Kyung Won Kim, Jinseok Lee
Summary: This study developed a personalized prognostic artificial intelligence (AI) model to predict 5 year survival at 1 year after gastric cancer surgery based on a large dataset. The AI model showed good performance in both internal and external validation, and the nutritional and fat/muscle indices contributed to the prediction performance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Surgery
Sin Hye Park, Woo Jin Hyung, Han-Kwang Yang, Young-Kyu Park, Hyuk-Joon Lee, Ji Yeong An, Wook Kim, Hyoung-Il Kim, Hyung-Ho Kim, Seung Wan Ryu, Hoon Hur, Min-Chan Kim, Seong-Ho Kong, Gyu Seok Cho, Jin-Jo Kim, Do Joong Park, Young-Woo Kim, Jong Won Kim, Joo-Ho Lee, Sang-Uk Han, Keun Won Ryu
Summary: The study did not find any survival benefit from regular follow-up after radical gastrectomy for gastric cancer, and it suggests the need for a prospective randomized controlled trial to determine the survival benefit.
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Oncology
Hoon Hur, Young Joon Lee, Young-Woo Kim, Jae-Seok Min, Hong Man Yoon, Ji Yeong An, Bang Wool Eom, Gyu Seok Cho, Young-Kyu Park, Mi Ran Jung, Ji-Ho Park, Woo Jin Hyung, Sang-Ho Jeong, Myeong-Cherl Kook, Mira Han, Byung-Ho Nam, Keun Won Ryu
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Sang-Yong Son, Bo Wang, Hoon Hur, Hyung-Ho Kim, Sang-Uk Han
Summary: This study investigated the influence of long-term exposure to BPA on gut microbial changes after bariatric surgery. The results showed that BPA was a risk factor for obesity and glucose intolerance, but it did not affect alterations of gut microbiome after bariatric/metabolic surgery.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)
Article
Oncology
Sun-Hwi Hwang, Do Joong Park, Hyung-Ho Kim, Woo Jin Hyung, Hoon Hur, Han-Kwang Yang, Hyuk-Joon Lee, Hyoung-Il Kim, Seong-Ho Kong, Young Woo Kim, Han Hong Lee, Beom Su Kim, Young-Kyu Park, Young-Joon Lee, Sang-Hoon Ahn, In-Seob Lee, Yun-Suhk Suh, Ji-Ho Park, Soyeon Ahn, Sang-Uk Han
Summary: This study compared the short-term outcomes of laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) and laparoscopic total gastrectomy (LTG) for upper early gastric cancer (EGC). The results showed no significant differences in operative time, estimated blood loss, morbidity rate, postoperative symptoms, and laboratory findings between the two groups.
JOURNAL OF GASTRIC CANCER
(2022)
Article
Oncology
Seohee Choi, Jae-Seok Min, Sang-Ho Jeong, Moon-Won Yoo, Young-Gil Son, Sung Jin Oh, Jong-Han Kim, Joong-Min Park, Hoon Hur, Ye Seob Jee, Sun-Hwi Hwang, Sung-Ho Jin, Sang Eok Lee, Young-Joon Lee, Kyung Won Seo, Sungsoo Park, Chang Min Lee, Chang Hyun Kim, In Ho Jeong, Han Hong Lee, Sung Il Choi, Sang-Il Lee, Chan-Young Kim, Hyundong Chae, Myoung-Won Son, Kyung Ho Pak, Sungsoo Kim, Moon-Soo Lee, Hyoung-Il Kim
Summary: This multicenter observational cohort study found significant differences in relapse-free survival (RFS) and overall survival (OS) between S-1 and CAPOX adjuvant chemotherapies in gastric cancer patients aged over 70 years. The S-1 group showed better survival outcomes in elderly patients compared to the CAPOX group.
JOURNAL OF GASTRIC CANCER
(2022)