Emerging drug targets for Aβand tau in Alzheimer's disease: a systematic review

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

(2013) Su-Yi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease

(2013) A. M. Barron et al.   JOURNAL OF NEUROSCIENCE

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease

(2013) Hirosha Geekiyanage et al.   NEUROBIOLOGY OF AGING

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

(2013) Rocio Perez-Gonzalez et al.   NEUROBIOLOGY OF AGING

Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways

(2013) Daniela Giuliani et al.   NEUROBIOLOGY OF AGING

Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease

(2013) Marybeth Camboni et al.   NEUROBIOLOGY OF DISEASE

Insulin growth factor binding protein 7 is a novel target to treat dementia

(2013) Hope Y. Agbemenyah et al.   NEUROBIOLOGY OF DISEASE

Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway

(2013) Juliana B. Hoppe et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500

(2013) Adrian C. Lo et al.   NEUROPHARMACOLOGY

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation

(2013) S. Chen et al.   NEUROSCIENCE

Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β(1–42) rat model of Alzheimer's disease

(2013) Oana Cioanca et al.   PHYSIOLOGY & BEHAVIOR

Optimized Turmeric Extract Reduces ?-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice

(2012) R. Douglas Shytle et al.   Current Alzheimer Research

Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

(2012) You Me Sung et al.   EXPERIMENTAL NEUROLOGY

Ergothioneine protects against neuronal injury induced by β-amyloid in mice

(2012) Nae-Cherng Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Reducing Amyloid-Related Alzheimer's Disease Pathogenesis by a Small Molecule Targeting Filamin A

(2012) H.-Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

(2012) Saila Vepsäläinen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Orally bioavailable small molecule drug protects memory in Alzheimer's disease models

(2012) Eugene O'Hare et al.   NEUROBIOLOGY OF AGING

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice

(2012) Rita M. Ramalho et al.   NEUROBIOLOGY OF AGING

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis

(2012) Di Xue et al.   NEUROBIOLOGY OF DISEASE

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo

(2012) Arthur L. Nikkel et al.   NEUROPHARMACOLOGY

Protective effect of cyanidin 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats

(2012) Lina Qin et al.   NEUROSCIENCE LETTERS

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

(2012) Il-Jun Kang et al.   NEUROTOXICOLOGY

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

(2011) Il-Jun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing

(2011) N C Inestrosa et al.   Translational Psychiatry

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

(2010) R. Scott Bitner et al.   NEUROPHARMACOLOGY

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY