Article
Chemistry, Multidisciplinary
Ines Cazin, Elisabeth Rossegger, Ignazio Roppolo, Marco Sangermano, Petra Granitzer, Klemens Rumpf, Sandra Schloegl
Summary: Additive manufacturing is a promising technique for fabricating customized 3D objects. Interest is growing in using magnetic materials for 3D printing functional devices. In this study, magnetic Fe3O4 nanoparticles were introduced into a dynamic photopolymer network, which allowed for thermo-activated bond exchange reactions and the healing of 3D-printed structures. The magnetically responsive composites showed potential for use in healable soft devices activated by external magnetic fields.
Article
Nanoscience & Nanotechnology
Guangyao Cheng, Kuan-Ting Lin, Yinghua Ye, Hang Jiang, To Ngai, Yi-Ping Ho
Summary: This study introduces a novel photo-responsive fluorosurfactant based on fluorinated plasmonic nanoparticles, which has shown effectiveness in stabilizing water-in-fluorocarbon oil droplets. The photothermal response enabled by the fluorinated gold-silica core-shell nanoparticles has potential for droplet movement and alteration of interfacial stability. The unique photo-responsiveness provided by the plasmonic nanoparticles is expected to enhance droplet microfluidics with an active surfactant for reconfigurable optical manipulation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Xinglong Pan, Nadia Grossiord, Jeroen A. H. P. Sol, Michael G. Debije, Albert P. H. J. Schenning
Summary: This study introduces an easy-to-process, anisotropic composite soft actuator based on a simple photothermal dye-doped polyethylene film, capable of large and controllable bending in response to light and various functions such as picking up cargo, diving, and surfing.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Fang Wang, Meijin Liu, Cong Liu, Qilong Zhao, Ting Wang, Zuankai Wang, Xuemin Du
Summary: Slippery lubricant-infused porous (SLIPS) and superhydrophobic surfaces have emerged as promising interfacial materials. We developed a class of slippery material that harnesses the dual advantages of both solid and lubricant by constructing a photothermal-responsive composite matrix with real-time light-induced surface charge regeneration capability. The resulting light-induced charged slippery surface (LICS) allows for photocontrol of droplets with fast speed, long distance, antigravity motion, and directionally collective motion. The LICS is further extended to biomedical domains for specific morphological hydrogel bead formation and biological diagnosis and analysis.
Article
Physics, Fluids & Plasmas
Arantxa Alonso, Oriol Batiste, Isabel Mercader
Summary: In this study, we numerically analyze the effect of a slight inclination in the lowest part of the snaking branches of convectons in negative separation ratio binary mixtures in two-dimensional elongated rectangular cells. We discover the existence of novel localized solutions with distinct spatial features. Moreover, we find that different families of localized structures can organize in closed branches, resulting in a highly complex scenario for solutions in the lowest part of the snaking diagrams.
Article
Multidisciplinary Sciences
Jesse Q. Zhang, Christian A. Siltanen, Ata Dolatmoradi, Chen Sun, Kai-Chun Chang, Russell H. Cole, Zev J. Gartner, Adam R. Abate
Summary: An automated approach using a commercial array spotter was described for generating droplet libraries quickly and efficiently, making combinatorial applications more feasible in droplet microfluidics. The method can produce high diversity droplet libraries without the need for microfluidic expertise.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Yvonne Wu, Leia Fan, Elaine Jian, Eric Lee
Summary: This study theoretically investigates the electrophoresis of dielectric fluid droplets with arbitrary surface potentials. It is found that the viscosity-dependence of droplet mobility is synchronized with the presence of an exterior vortex flow surrounding the droplet, and critical points are discovered for highly charged droplets where the droplet surface becomes immobile and the interior fluid becomes motionless.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ghassan Hassan, Bekir Sami Yilbas, Abba Abdulhamid Abubakar, Hussain Al-Qahtani, Abdullah Al-Sharafi
Summary: Developing manipulation techniques for ferrofluid droplets is important for sustainable applications. This study investigates the dynamics of droplet motion on functionalized and non-functionalized ferroparticles and discovers a transformation from sliding to rolling motion under magnetic influence.
Review
Automation & Control Systems
Yusen Zhao, Mutian Hua, Yichen Yan, Shuwang Wu, Yousif Alsaid, Ximin He
Summary: This article reviews recent progress in the use of stimuli-responsive polymers for soft robotics. Different types of representative stimuli-responsive polymers are introduced, and their actuation mechanisms and performance evaluation are discussed. Examples of soft robotic applications based on stimuli-responsive polymers are presented. Current opportunities and challenges of stimuli-responsive soft robots for future study are discussed.
ANNUAL REVIEW OF CONTROL ROBOTICS AND AUTONOMOUS SYSTEMS
(2022)
Article
Chemistry, Multidisciplinary
Ze-Jiu Diao, Si-Yi Liu, Hui Wen, Guoliang Liu, Tao Yang, Jing-Jing Li, Xiao-Qin Liu, Lin-Bing Sun
Summary: Stimuli-responsive porous materials based on detachment mechanism were developed by fabricating a detachable porous organic polymer, DT-POP-1, from the polymerization of anthracene-containing monomer (AnMon) induced by 365 nm UV light. DT-POP-1 could detach into the monomer AnMon under 275 nm UV light or heat, and this polymerization/detachment process was reversible. The significant difference in porosity and adsorption capacity caused by the detachment makes the present detachable porous polymer highly promising in adsorptive separation and drug delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Longzhu Zheng, Hongqiang Li, Wei Huang, Xuejun Lai, Xingrong Zeng
Summary: This study presents a light stimuli-responsive superhydrophobic film with large and sensitive deformed actuations driven by light stimuli, which exhibits high sensitivity, great repeatability, and superhydrophobicity. The film can be used for water-droplet manipulation and designed as an electric switch for remotely controlling circuits.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Inorganic & Nuclear
Wei Xiao, Meishuang Qiu, Yan Peng, Tianyou Chen, Changfeng Yi, Zushun Xu
Summary: The study focuses on the development of UV light-regulated cooperative catalysts using azobenzene-containing polyimides as supports. Through aromatic stacking interactions and hydrophobic interactions, catalytic components were immobilized onto polyimides, forming nanocatalysts with controllable UV light-responsive behaviors. This strategy has potential applications in designing multifunctional heterogeneous catalysts.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Quan Liu, Guodong Yu, Chongyu Zhu, Bo Peng, Ruohan Li, Tao Yi, Yanlei Yu
Summary: By integrating Laplace pressure and capillary condensation in a photodeformable microfluidic platform, various liquid operations such as propulsion, fusion, separation, and mixing of liquid slugs can be achieved without the need for microvalves. This technology has potential applications in miniaturized biomedical fields like portable analysis systems.
Article
Chemistry, Multidisciplinary
Agnieszka Jedrych, Mateusz Pawlak, Ewa Gorecka, Wiktor Lewandowski, Michal Maksymilian Wojcik
Summary: We have demonstrated the fabrication of dual-responsive (thermo/light) chiral plasmonic films by using photoswitchable achiral liquid crystal (LCs) for templating helical assemblies of Au NPs. The chiroptical properties of the organic and inorganic components were confirmed by circular dichroism spectroscopy (CD), with a dissymmetry factor (g-factor) of up to 0.2. The controlled melting of organic nanotubes and/or inorganic nanohelices can be achieved by exposing the material to UV light and can be reversed using visible light, with the chiroptical response further modified by varying the temperature.
Article
Polymer Science
Shu Wang, Purushottam Poudel, Felix H. Schacher, Leonid I. Kaberov
Summary: In this work, a method for synthesizing temperature and light-responsive copolymers by introducing azobenzene fragments in the side chain of poly(2-oxazoline)s is proposed. The obtained copolymers exhibited thermo-responsive behavior and reversible isomerization of azobenzene units under UV and visible light exposure. The presence of nanoparticles in the aqueous solutions of the copolymers was confirmed, and the size of these nanoparticles changed in response to UV irradiation.
Article
Multidisciplinary Sciences
Mehdi Rahmanian, Omid Sartipzadeh Hematabad, Esfandyar Askari, Farhad Shokati, Atin Bakhshi, Shiva Moghadam, Asiie Olfatbakhsh, Esmat Al Sadat Hashemi, Mohammad Khorsand Ahmadi, Seyed Morteza Naghib, Nidhi Sinha, Jurjen Tel, Hossein Eslami Amirabadi, Jaap M. J. den Toonder, Keivan Majidzadeh-A
Summary: This study demonstrates the use of a novel micropillar array-based microfluidic chip (MPA-Chip) for isolating circulating tumor cells (CTCs) from the blood of cancer patients, providing prognostic information and monitoring treatment efficacy. The lozenge geometry of the MPA-Chip was found to be the most effective design, with high capture efficiency (>85%), purity (>90%), and viability (97%).
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Ashuya Takemoto, Teppei Araki, Kazuya Nishimura, Mihoko Akiyama, Takafumi Uemura, Kazuki Kiriyama, Johan M. Koot, Yuko Kasai, Naoko Kurihira, Shuto Osaki, Shin-ichi Wakida, Jaap M. J. den Toonder, Tsuyoshi Sekitani
Summary: Fully transparent, ultrathin, and flexible organic electrochemical transistors (OECTs) were successfully developed using the additive integration processes of selective-wetting deposition and thermally bonded lamination. These OECTs demonstrate high visible transmittance and high transconductance, with low-voltage operations. EEG acquisition and nitrate ion sensing can be performed while wearing the transparent OECTs, and simultaneous assessments of optical blood flowmetry are also compatible.
Article
Chemistry, Analytical
Eva A. van Aalen, Bas J. H. M. Rosier, Tom Jansen, Simone F. A. Wouters, Robin T. Vermathen, Harmen J. van der Veer, Jose Yeste Lozano, Sheeza Mughal, Juan M. Fernandez-Costa, Javier Ramon-Azcon, Jaap M. J. den Toonder, Maarten Merkx
Summary: Immunoassays have great potential for detecting low levels of cytokines with high sensitivity and excellent specificity. A novel bioluminescent immunoassay, called dRAPPID, has been developed for the detection of IL-6 and TNF-alpha. The dRAPPID assay showed improved signal-to-background ratio and increased luminescent signal. It was also integrated into a microfluidic device for simultaneous and continuous monitoring of IL-6 and TNF-alpha.
ANALYTICAL CHEMISTRY
(2023)
Article
Mechanics
Edwin De Jong, Mark L. van der Klok, Jaap M. J. Den Toonder, Patrick R. Onck
Summary: Capillary forces are commonly used in microfluidic systems, but mixing small fluid volumes is challenging due to laminar flow. This study shows that by compressing the capillary interaction between droplets and deforming surfaces, vortex-like flow patterns can be generated to effectively mix droplet contents. Two strategies were introduced to quantify mixing performance, independent of initial solute distribution within a droplet. These results can be used to design efficient droplet mixers using mechanowetting as a new enabling technology.
Article
Multidisciplinary Sciences
Maurice Dekker, Erik Van der Giessen, Patrick R. Onck
Summary: The intrinsically disordered FG-Nups in the central channel of the nuclear pore complex (NPC) form a selective permeability barrier and undergo phase separation, with GLFG-Nups acting as hydrophobic stickers essential for the formation of FG-Nup condensates. The different FG-Nups can be divided into two classes based on their observed phase separation behavior: the central FG-Nups form a dynamic percolated network, while the peripheral FG-Nups likely form an entropic brush.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Shuaizhong Zhang, Xinghao Hu, Meng Li, Ugur Bozuyuk, Rongjing Zhang, Eylul Suadiye, Jie Han, Fan Wang, Patrick Onck, Metin Sitti
Summary: Researchers have created wirelessly actuated magnetic artificial cilia at the micrometer scale that are biocompatible and programmable. By programming the orientation of the magnetic microparticles, the cilia can exhibit coordinated metachronal motions, allowing for the generation of versatile microfluidic patterns. This development offers a novel solution for programmable microfluidic systems, biomedical engineering, and biocompatible implants.
Article
Polymer Science
Kalpit J. Bakal, Andreas M. A. O. Pollet, Jaap M. J. den Toonder, Hans M. Wyss
Summary: This study investigates the static and dynamic response of polyacrylamide (PAAm) particles under direct contact forces and osmotic forces. It is found that the particles exhibit higher static compressive and shear elastic moduli in dextran solutions compared to water, and they deform at a slower rate under applied external forces in dextran solutions, which can be explained by the diffusion of dextran molecules in the surrounding solution.
Article
Engineering, Biomedical
Tom C. L. Bracco Gartner, Ye Wang, Laurynas Leiteris, Iris van Adrichem, Judith Marsman, Marie Jose Goumans, Carlijn V. C. Bouten, Joost P. G. Sluijter, Jaap M. J. den Toonder, Willem J. L. Suyker, Jesper Hjortnaes
Summary: Cardiac fibroblasts in the ever-beating human heart remain quiescent due to the antifibrotic effect of cyclic strain conditions revealed by a novel platform for studying cardiac fibrosis-on-a-chip. This study provides insights into the mechanosensitive pathways and genes involved in the fibrogenic process, which can contribute to the development of new therapies against cardiac fibrosis.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Bhavana B. Venkataramanachar, Jianing Li, Tanveer ul Islam, Ye Wang, Jaap M. J. den Toonder
Summary: Evolution has created natural systems that can generate motion and sense external stimuli at the micro- and nanoscales. To mimic these systems for scientific and engineering applications, we have developed a process to prepare nanomagnetic elastomers with high magnetic particle concentrations. Through extensive mechanical and magnetic characterization, we have achieved a material with the highest magnetic-to-elastic force ratio. We have also successfully fabricated and actuated micro- and nanostructures resembling cilia, showcasing the extreme compliance and responsiveness of the developed materials.
Article
Multidisciplinary Sciences
Zhiwei Cui, Ye Wang, Shuaizhong Zhang, Tongsheng Wang, Jaap M. J. den Toonder
Summary: Researchers have developed a new method to generate periodic motion by integrating a paramagnetic substructure in the substrate underneath artificial cilia. By changing the relative positions of the substructure and artificial cilia, different types of periodic motion can be created. This research breaks the size limitation barrier in metachronal artificial cilia and showcases the potential of nature-inspired engineering.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Nanoscience & Nanotechnology
Ines C. F. Pereira, Ralph J. S. van Mechelen, Hans M. Wyss, Leonard Pinchuk, Henny J. M. Beckers, Jaap M. J. den Toonder
Summary: Researchers have developed a miniature glaucoma implant that can reduce intraocular pressure and prevent disease progression. The implant features a magnetic microvalve that can be adjusted externally to control fluid flow, allowing for better treatment outcomes and minimizing complications for glaucoma patients.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Physics, Fluids & Plasmas
R. Pramanik, R. W. C. P. Verstappen, P. R. Onck
Summary: This study uses computational simulation to investigate the swimming kinematics and induced flow field dynamics of jellyfish-inspired soft robotic swimmers. The researchers explore the kinematic performance of the jellyfishbot through a parametric sweep of different system parameters. They find that applying an appropriate magnetic field and controlling the remnant magnetization profile can enhance the temporal and spatial asymmetries in the soft magnetic composite elastomeric lappets, leading to improved swimming speed.
Article
Biochemical Research Methods
Stef Broeren, Ines Figueiredo Pereira, Tongsheng Wang, Jaap den Toonder, Ye Wang
Summary: Researchers have developed an on-demand micromixer based on magnetic microwalls, which can achieve controllable mixing and complete mixing shut-off in commercial microfluidic devices. The microwalls can create a meandering path in the main channel to enable mixing or open up the channel to stop mixing, controlled by a simple magnet. Experimental results show that the microwalls can effectively enhance mixing in colored fluids with different flow rates and viscosities.