Review
Surgery
Nadia A. G. Hakkenbrak, Elise P. Jansma, N. van der Wielen, Donald L. van der Peet, Jennifer Straatman
Summary: This meta-analysis aims to compare laparoscopic distal gastrectomy (LDG) and open distal gastrectomy (ODG) in terms of short-term and long-term surgical outcomes, recovery, and oncological results. The results show that LDG leads to less intraoperative blood loss, faster patient recovery, and fewer complications. Moreover, LDG meets the clinical requirements in terms of lymph node yield, adequacy of resection, and survival.
Article
Surgery
Jun Lu, Chao-Hui Zheng, Bin-Bin Xu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Chang-Ming Huang, Ping Li
Summary: Evaluation of short-term outcomes for patients with GC who underwent RDG or LDG showed that RDG had lower postoperative morbidity, faster recovery, milder inflammatory responses, and improved lymphadenectomy compared to LDG. Additionally, patients in the RDG group were more likely to initiate adjuvant chemotherapy earlier, despite higher total hospital costs.
Article
Surgery
Changming Huang, Hao Liu, Yanfeng Hu, Yihong Sun, Xiangqian Su, Hui Cao, Jiankun Hu, Kuan Wang, Jian Suo, Kaixiong Tao, Xianli He, Hongbo Wei, Mingang Ying, Weiguo Hu, Xiaohui Du, Jiang Yu, Chaohui Zheng, Fenglin Liu, Ziyu Li, Gang Zhao, Jiachen Zhang, Pingyan Chen, Guoxin Li
Summary: The study found that laparoscopic distal gastrectomy with D2 lymphadenectomy performed by experienced surgeons in high-volume specialized institutions resulted in similar 5-year overall survival compared with open distal gastrectomy among patients with locally advanced gastric cancer. This randomized clinical trial reports 5-year overall survival data from the CLASS-01 trial of laparoscopic vs open distal gastrectomy among patients with locally advanced gastric cancer.
Article
Oncology
Hua Xiao, Yanping Xiao, Pan Chen, Hu Quan, Jia Luo, Gang Huang
Summary: The study investigated the impact of perioperative blood transfusion (BTF) and postoperative infections on cancer-specific survival (CSS) in patients with stage II/III gastric cancer after radical gastrectomy. Both BTF and infections independently predicted poor CSS, and their additive effect resulted in even worse CSS. However, completing adjuvant chemotherapy significantly improved CSS in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Jun Lu, Bin-bin Xu, Li-li Shen, Dong Wu, Zhen Xue, Hua-Long Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li
Summary: This study described the characteristics of GC RCTs in the past 20 years, identified a burden of research waste, and may provide evidence for the development of rational RCTs and reduction of waste in the future.
Article
Surgery
Li Zheng-yan, Zhao Yong-liang, Qian Feng, Shi Yan, Yu Pei-wu
Summary: This study compared the outcomes of robotic distal gastrectomy (RDG) and laparoscopic distal gastrectomy (LDG) in treating gastric cancer. It found no significant differences in postoperative complications and mortality between RDG and LDG, with RDG showing less blood loss and more retrieved lymph nodes. Age over 65 and ASA III were identified as major risk factors for complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Satoshi Suzuki, Arata Takahashi, Takashi Ishikawa, Kohei Akazawa, Hitoshi Katai, Yoh Isobe, Isao Miyashiro, Hiroyuki Ono, Satoshi Tanabe, Takeo Fukagawa, Kei Muro, Souya Nunobe, Shigenori Kadowaki, Haruhisa Suzuki, Tomoyuki Irino, Shiyori Usune, Hiroaki Miyata, Yoshihiro Kakeji
Summary: The NCD gastric cancer registry program demonstrated the validity of database construction and provided treatment results of the real world. Among the 25306 gastric cancer cases that underwent surgical resection in the NCD database, the 5-year survival rate was 71.3%.
Article
Multidisciplinary Sciences
Dong Yeon Kang, Ho Goon Kim, Dong Yi Kim
Summary: This study demonstrates that reduced-port laparoscopic distal gastrectomy can be performed safely in obese patients with gastric cancer, with comparable operative outcomes to non-obese patients.
Article
Oncology
Marianna Maspero, Carlo Sposito, Antonio Benedetti, Matteo Virdis, Maria Di Bartolomeo, Massimo Milione, Vincenzo Mazzaferro
Summary: The adequacy of surgical resection margins to JGCA guidelines leads to improved survival outcomes and allows for a more organ-preserving approach than Western guidelines.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
W. J. Koemans, A. Houwink, R. T. van der Kaaij, E. C. E. Wassenaar, D. Boerma, C. Hahn, O. Imhof, M. G. Brandt, M. P. Ariens, A. A. F. A. Veenhof, K. J. Hartemink, J. W. van Sandick
Summary: A strict nutritional protocol during the PERISCOPE I study was associated with a decrease in postoperative complications for gastric cancer patients with limited peritoneal dissemination. Changes in perioperative management, especially related to nutrition, can have a significant impact on patient outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yuan Tian, Peigang Yang, Yecheng Lin, Yiyang Hu, Huiyan Deng, Wenqian Ma, Honghai Guo, Yang Liu, Ze Zhang, Pingan Ding, Yong Li, Liqiao Fan, Zhidong Zhang, Dong Wang, Qun Zhao
Summary: This study compared the number of lymph nodes detected in gastric cancer patients receiving carbon nanoparticle suspension injection (CNSI) versus no injection. The results showed that CNSI led to a significantly higher number of lymph nodes detected. Carbon nanoparticle suspension-guided lymphography may be an alternative to conventional systematic lymphadenectomy for distal gastrectomy.
Article
Surgery
Ru-Hong Tu, Jian-Xian Lin, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ze-Ning Huang, Ju-Li Lin, Hua-Long Zheng, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: Laparoscopic gastrectomy after neoadjuvant chemotherapy can achieve improved short-term outcomes without increasing the risk of postoperative complications.
Article
Multidisciplinary Sciences
Tomosuke Mukoyama, Shingo Kanaji, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
Summary: This study aimed to investigate the risk factors and severity of delayed gastric emptying (DGE) after gastrectomy. Female sex, diabetes, and distal gastric tumors were identified as independent risk factors for DGE. The DGE group had a longer hospital stay compared to the non-DGE group, and most DGE cases occurred after 1 week following surgery.
SCIENTIFIC REPORTS
(2022)
Review
Surgery
Chunfang Lin, Haibo Fan, Wenjun Chen, Lingzhi Cui
Summary: This meta-analysis compared outcomes of palliative gastrectomy and gastrojejunostomy in patients with metastatic advanced gastric cancer, finding no significant differences in overall survival duration, complication risks, time to oral intake, and hospital stay length between the two procedures.
FRONTIERS IN SURGERY
(2021)
Article
Multidisciplinary Sciences
Yunhe Gao, Hongqing Xi, Fredrik Mattsson, Wenquan Liang, Shao-Hua Xie, Lin Chen, Jesper Lagergren
Summary: Previous studies have shown that the surgical starting time of the day may affect the long-term survival of gastric cancer patients. This cohort study included 2728 patients who underwent curatively intended gastrectomy for gastric cancer in China. The results indicated that starting surgery in the early morning might be associated with better long-term survival, especially for patients who underwent laparoscopic gastrectomy and those with stage II tumors.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Koki Shimada, Hiroyuki Yamamoto, Eiji Nakatani, Hiraku Kumamaru, Shiori Nishimura, Nao Ichihara, Norimichi Hirahara, Kiyoshi Mori, Masato Kotani, Yoshiki Miyachi, Hiroaki Miyata
Summary: The study aimed to evaluate the incidence of T1DM and hypothyroidism after PD-1 inhibitor treatment, and found that factors such as female gender, lung cancer, and urothelial carcinoma were significantly associated with the risk of hypothyroidism.
ENDOCRINE PRACTICE
(2021)
Article
Oncology
Satoru Furuhashi, Yoshifumi Morita, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Katsunori Suzuki, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kiyotaka Kurachi, Yoji Shido, Ken Sugimoto, Hiroaki Ito, Yuichiro Maekawa, Hiroyuki Mineta, Hideaki Miyake, Hiroya Takeuchi
Summary: Patients with head and neck malignancy or TICVAP insertion in the upper arm have a potentially increased risk for late-phase TICVAP-related infections.
ANTICANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yujiro Ide, Hisateru Tachimori, Yasutaka Hirata, Norimichi Hirahara, Noritaka Ota, Kisaburo Sakamoto, Tadashi Ikeda, Kenji Minatoya
Summary: Research shows that smaller patients with complex cardiac anomalies have a higher mortality rate after systemic-to-pulmonary shunt procedures in patients with a functionally univentricular heart.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Katsunori Suzuki, Yasuo Takehara, Mayu Sakata, Masanori Kawate, Naoki Ohishi, Kosuke Sugiyama, Toshiya Akai, Yuhi Suzuki, Masataka Sugiyama, Takafumi Kawamura, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Masayoshi Yamamoto, Hatsuko Nasu, Kevin Johnson, Oliver Wieben, Kiyotaka Kurachi, Hiroya Takeuchi
Summary: 4D PC-VIPR is an effective imaging technique for assessing superior mesenteric artery flow, especially after stimulation with herbal medicine, showing significant correlations with DUS and the ability to analyze multiple blood vessels simultaneously.
Article
Surgery
Ryoma Haneda, Eisuke Booka, Kenjiro Ishii, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kinji Kamiya, Hirofumi Ogawa, Hirofumi Yasui, Hiroya Takeuchi, Yasuhiro Tsubosa
Summary: Definitive chemoradiotherapy may be a promising alternative therapy comparable with radical esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma. Early detection of recurrence by frequent follow-up after definitive chemoradiotherapy is crucial for controlling disease within local recurrence, and salvage therapy for local lesions could contribute to long-term survival.
WORLD JOURNAL OF SURGERY
(2021)
Article
Surgery
Yoshifumi Morita, Takanori Sakaguchi, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
Summary: This study retrospectively analyzed patients who underwent pancreaticoduodenectomy (PD) and proposed a perioperative fluid and nutritional therapy strategy based on the risk stratification by pancreatic fistula (PF) and delayed gastric emptying (DGE). The study found that severe PF and DGE were significant risk factors for body weight loss (>10%). The study also observed that fluid imbalance and stomach preserving PD were associated with the incidence of DGE.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Ryoma Haneda, Yoshihiro Hiramatsu, Sanshiro Kawata, Junko Honke, Wataru Soneda, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Kinji Kamiya, Hiroya Takeuchi
Summary: The study found that changes in prognostic nutritional index levels during the perioperative period significantly impact overall survival in esophageal cancer patients. Increasing postoperative nutritional index levels in patients with poor preoperative nutritional status can improve prognosis after esophagectomy.
Article
Gastroenterology & Hepatology
Hirotoshi Kikuchi, Hideki Endo, Hiroyuki Yamamoto, Soji Ozawa, Hiroaki Miyata, Yoshihiro Kakeji, Hisahiro Matsubara, Yuichiro Doki, Yuko Kitagawa, Hiroya Takeuchi
Summary: A study using data from the Japanese National Clinical Database found that the posterior mediastinal (PM) reconstruction route in esophagectomy followed by gastric conduit reconstruction is associated with lower risks of anastomotic leak and surgical site infection (SSI), but a higher risk of pneumonia, while the retrosternal (RS) reconstruction route has higher risks of anastomotic leak and SSI, but a lower risk of pneumonia. This information can help surgeons in designing the reconstruction route following esophagectomy.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Kyota Tatsuta, Mayu Sakata, Moriya Iwaizumi, Kazuya Shinmura, Toshiya Akai, Takafumi Kawamura, Kakeru Torii, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Atsuko Fukazawa, Kiyotaka Kurachi, Hiroya Takeuchi
Summary: In this case, an unusual colon carcinoma with a null phenotype in MMR protein immunohistochemistry was presented. The loss of MMR protein expression can be explained by somatic loss of MLH1 and MSH2 functions, functional loss in all four MMR proteins due to somatic mutations, or Lynch-like syndrome. It is essential to correctly interpret and accumulate relevant cases to identify unusual cases, especially in the era of universal screening.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Eisuke Booka, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
Summary: Esophagectomy remains a highly invasive procedure for esophageal cancer, with severe postoperative complications such as infections. Research indicates that postoperative infections can significantly impact long-term survival and that minimally invasive approaches may help reduce these complications. Future treatment strategies for esophageal cancer should take into account the risks and effects of postoperative infectious complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Yoshihiro Hiramatsu, Hirotoshi Kikuchi, Hiroya Takeuchi
Summary: Function-preserving gastrectomy, such as proximal gastrectomy and pylorus-preserving gastrectomy, have been widely accepted as methods to improve quality of life for patients with early gastric cancer (EGC). The development of personalized, minimized gastrectomy with sentinel node navigation surgery is expected to provide an ideal treatment option.
Article
Medicine, General & Internal
Eisuke Booka, Hirotoshi Kikuchi, Ryoma Haneda, Wataru Soneda, Sanshiro Kawata, Tomohiro Murakami, Tomohiro Matsumoto, Yoshihiro Hiramatsu, Hiroya Takeuchi
Summary: This study investigated the relationship between serum procalcitonin (PCT) levels after esophagectomy and infectious complications and long-term prognosis. The results showed that the association between PCT levels and infectious complications became stronger as the postoperative days passed, with a 100% positive predictive value at 7 days post-operation. Additionally, patients in the low PCT group at 2 days post-operation had significantly worse overall survival and recurrence-free survival. Advanced pathological stage and low PCT levels at 2 days post-operation were identified as independent predictors of worse overall survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Amane Hirotsu, Hirotoshi Kikuchi, Hidenao Yamada, Yusuke Ozaki, Ryoma Haneda, Sanshiro Kawata, Tomohiro Murakami, Tomohiro Matsumoto, Yoshihiro Hiramatsu, Kinji Kamiya, Daisuke Yamashita, Yuki Fujimori, Yukio Ueda, Shigetoshi Okazaki, Masatoshi Kitagawa, Hiroyuki Konno, Hiroya Takeuchi
Summary: This study developed a label-free image recognition system that can identify rare cells in the bloodstream and monitor the treatment progress of cancer patients.
Article
Cardiac & Cardiovascular Systems
Hideyuki Shimizu, Norimichi Hirahara, Noboru Motomura, Hiroaki Miyata, Shinichi Takamoto
Summary: An analysis of thoracic/thoracoabdominal aortic diseases treatment status in Japan revealed that the most common age group for surgery was patients in their 70s. Elderly patients showed higher mortality and morbidity rates, particularly in procedures for patients aged 80 years or older. Further improvements in surgical outcomes are needed to enhance overall patient outcomes.
ASIAN CARDIOVASCULAR & THORACIC ANNALS
(2021)
Article
Surgery
Yuhi Suzuki, Masayoshi Yamamoto, Kosuke Sugiyama, Toshiya Akai, Katsunori Suzuki, Takafumi Kawamura, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kiyotaka Kurachi, Naoki Unno, Hiroya Takeuchi
Summary: The study found that after 1 and 3 hours of reperfusion following intestinal ischemia, normal tissue oxygenation saturation was restored and good survival rates were achieved, but after 6 hours of ischemia, tissue saturation did not improve upon reperfusion and survival rates were lower. The tissue oximeter performed well in evaluating intestinal ischemia and viability.