Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy

Chemokines are a large subfamily of cytokines known for their ability to facilitate cell migration, most notably leukocytes, throughout the body. Chemokines are necessary for a functioning immune system in both health and disease and have received considerable attention for their roles in orchestrating temporal-spatial regulation of immune cell populations in cancer. Gliomas comprise a group of common central nervous system (CNS) primary tumors that are extremely challenging to treat. Immunotherapy approaches for highly malignant brain tumors offer an exciting new avenue for therapeutic intervention but so far, have seen limited successful clinical outcomes. Herein we focus on important chemokine/chemokine receptor systems in the regulation of pro-and anti-tumor mechanisms, highlighting potential therapeutic advantages of modulating these systems in malignant gliomas and other cancers. (c) 2020 Elsevier Inc. All rights reserved.

Automated summary

Chemokines play a crucial role in regulating cell migration, particularly in the immune system and cancer. Gliomas, as common and challenging primary tumors of the central nervous system, could potentially benefit from immunotherapy approaches. Manipulating chemokine/chemokine receptor systems may offer therapeutic advantages in treating malignant gliomas and other cancers.