CNG channel structure, function, and gating: a tale of conformational flexibility

Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel

(2020) Xiangdong Zheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric conformational change of a cyclic nucleotide-gated ion channel revealed by DEER spectroscopy

(2020) Eric G. B. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM

(2019) Ricardo D. Righetto et al.   Nature Communications

History, rare, and multiple events of mechanical unfolding of repeat proteins

(2018) Fidan Sumbul et al.   JOURNAL OF CHEMICAL PHYSICS

Ligand binding and activation properties of the purified bacterial cyclic nucleotide–gated channel SthK

(2018) Philipp A.M. Schmidpeter et al.   JOURNAL OF GENERAL PHYSIOLOGY

The gating mechanism in cyclic nucleotide-gated ion channels

(2018) Monica Mazzolini et al.   Scientific Reports

Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

(2018) Jan Rheinberger et al.   eLife

Structural titration of receptor ion channel GLIC gating by HS-AFM

(2018) Yi Ruan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

(2018) Arin Marchesi et al.   Nature Communications

The permeation mechanism of organic cations through a CNG mimic channel

(2018) Luisa M. R. Napolitano et al.   PLoS Computational Biology

Evolution and Structural Characteristics of Plant Voltage-Gated K+ Channels

(2018) Timothy Jegla et al.   PLANT CELL

Structural insights into the mechanisms of CNBD channel function

(2017) Zachary M. James et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a eukaryotic cyclic-nucleotide-gated channel

(2017) Minghui Li et al.   NATURE

CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel

(2017) Zachary M. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating

(2016) Dorothy M. Kim et al.   Cold Spring Harbor Perspectives in Biology

Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

(2016) Martina Rangl et al.   Nature Communications

Evolution of voltage-gated ion channels at the emergence of Metazoa

(2015) Y. Moran et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Ether-a-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor

(2015) X. Li et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Proton transfer unlocks inactivation in cyclic nucleotide-gated A1 channels

(2015) Arin Marchesi et al.   JOURNAL OF PHYSIOLOGY-LONDON

A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels

(2015) Luisa Maria Rosaria Napolitano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How cryo-EM is revolutionizing structural biology

(2015) Xiao-chen Bai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Filming Biomolecular Processes by High-Speed Atomic Force Microscopy

(2014) Toshio Ando et al.   CHEMICAL REVIEWS

K2P channels in plants and animals

(2014) Wendy González et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel

(2014) T. J. Harpole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Family of prokaryote cyclic nucleotide-modulated ion channels

(2014) M. Brams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Secondary Structural Transition in the C-helix Promotes Gating of Cyclic Nucleotide-regulated Ion Channels

(2013) Michael C. Puljung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The voltage-sensing domain of a phosphatase gates the pore of a potassium channel

(2013) Cristina Arrigoni et al.   JOURNAL OF GENERAL PHYSIOLOGY

Polyproline-II Helix in Proteins: Structure and Function

(2013) Alexei A. Adzhubei et al.   JOURNAL OF MOLECULAR BIOLOGY

Catalysis of Na+ permeation in the bacterial sodium channel NaVAb

(2013) N. Chakrabarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Transfer from Bacteria and Archaea Facilitated Evolution of an Extremophilic Eukaryote

(2013) G. Schonknecht et al.   SCIENCE

A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions

(2012) Arin Marchesi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adaptive evolution of voltage-gated sodium channels: The first 800 million years

(2012) H. H. Zakon   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating of cyclic nucleotide-gated channels is voltage dependent

(2012) Arin Marchesi et al.   Nature Communications

Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel

(2011) S. Schunke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Shaker K+ Channel with a Miniature Engineered Voltage Sensor

(2010) Yanping Xu et al.   CELL

Extracellular protons titrate voltage gating of a ligand-gated ion channel

(2010) Juan Ramón Martínez-François et al.   JOURNAL OF GENERAL PHYSIOLOGY

Voltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel

(2010) Harley T. Kurata et al.   PLOS BIOLOGY

Solution structure of the Mesorhizobium loti K1 channel cyclic nucleotide-binding domain in complex with cAMP

(2009) Sven Schünke et al.   EMBO REPORTS

Conformational rearrangements in the S6 domain and C-linker during gating in CNGA1 channels

(2009) Anil V. Nair et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Mutations reveal voltage gating of CNGA1 channels in saturating cGMP

(2009) Juan Ramón Martínez-François et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gating in CNGA1 channels

(2009) Monica Mazzolini et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain

(2008) Stephen L. Altieri et al.   JOURNAL OF MOLECULAR BIOLOGY

Gating at the selectivity filter in cyclic nucleotide-gated channels

(2008) J. E. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA