Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/6301433
Keywords
-
Categories
Funding
- Key R&D Plan of Shaanxi Province [2021SF-025]
- Natural Science Foundation of Shaanxi Province [2020JQ940]
Ask authors/readers for more resources
Osteoporosis is an aging-related disease characterized by permanent bone tissue atrophy, with most patients exhibiting high levels of oxidative stress. Exosomes play a role in delivering miRNAs for intercellular communication in OP, modulating physiological processes including the response to oxidative stress. Research delves into the interaction between exosomal miRNAs and oxidative stress in OP, with a focus on the potential advantages of exo-based miRNA delivery in treatment strategies.
Osteoporosis (OP) is an aging-related disease involving permanent bone tissue atrophy. Most patients with OP show high levels of oxidative stress (OS), which destroys the microstructure of bone tissue and promotes disease progression. Exosomes (exos) help in the delivery of microRNAs (miRNAs) and allow intercellular communication. In OP, exosomal miRNAs modulate several physiological processes, including the OS response. In the present review, we aim to describe how exosomal miRNAs and OS contribute to OP. We first summarize the relationship of OS with OP and then detail the features of exos along with the functions of exo-related miRNAs. Further, we explore the interplay between exosomal miRNAs and OS in OP and summarize the functional role of exos in OP. Finally, we identify the advantages of exo-based miRNA delivery in treatment strategies for OP. Our review seeks to improve the current understanding of the mechanism underlying OP pathogenesis and lay the foundation for the development of novel theranostic approaches for OP.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available