New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones

Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites

(2020) Naja Eberhard et al.   Frontiers in Veterinary Science

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials

(2020) Papireddy Kancharla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis

(2020) Jean Joel Bigna et al.   Scientific Reports

Recent Advancement of Ullmann Condensation Coupling Reaction in the Formation of Aryl-Oxygen (C-O) Bonding by Copper-Mediated Catalyst

(2020) Choong Jian Fui et al.   Catalysts

Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

(2020) Marta G. Silva et al.   Parasites & Vectors

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

(2019) Andrew R. Bogdan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Type X strains of Toxoplasma gondii are virulent for southern sea otters ( Enhydra lutris nereis) and present in felids from nearby watersheds

(2019) Karen Shapiro et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers

(2019) Rory T. Gallagher et al.   ADVANCED SYNTHESIS & CATALYSIS

Targeted Structure–Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

(2018) Erin V. McConnell et al.   ACS Infectious Diseases

Merging π-Acid and Pd Catalysis: Dearomatizing Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered Aromatics

(2018) Hon Eong Ho et al.   ACS Catalysis

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis

(2018) Reto Rufener et al.   International Journal for Parasitology-Drugs and Drug Resistance

Scalable Multigram Syntheses of Antimalarial 4(1H )-Quinolones ELQ-300 and P4Q-391

(2017) Niranjan K. Namelikonda et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum

(2017) Joachim Müller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor

(2017) Jennifer Tsoung et al.   JOURNAL OF ORGANIC CHEMISTRY

Drugs in development for toxoplasmosis: advances, challenges, and current status

(2017) Holland Alday et al.   Drug Design Development and Therapy

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

(2017) Lisa Frueh et al.   ACS Infectious Diseases

Inhibition of Cytochrome bc 1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy

(2015) Allison M. Stickles et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: An Immediate Access to Diverse 3-Aryl-4(1H)-Quinolones

(2015) Andrii Monastyrskyi et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition-Metal-Free C-3 Arylation of Quinoline-4-ones with Arylhydrazines

(2015) Makthala Ravi et al.   JOURNAL OF ORGANIC CHEMISTRY

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

(2014) Aaron Nilsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

(2014) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Practical Synthesis of Indoles via a Pd-Catalyzed C–N Ring Formation

(2014) Rishi G. Vaswani et al.   ORGANIC LETTERS

Dithiocarbamates: Reagents for the Removal of Transition Metals from Organic Reaction Media

(2014) William P. Gallagher et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Arylation with Unsymmetrical Diaryliodonium Salts: A Chemoselectivity Study

(2013) Joel Malmgren et al.   CHEMISTRY-A EUROPEAN JOURNAL

Application Progress of Recent Advances in Some Copper Catalyzed Coupling Reactions

(2013) Sunil Tekale et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

(2013) A. Nilsen et al.   Science Translational Medicine

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

(2012) Chandrakala Pidathala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

(2012) J. S. Doggett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of endochin-like quinolones for antimalarial activity

(2010) Rolf Winter et al.   EXPERIMENTAL PARASITOLOGY

Divergent Route to Access Structurally Diverse 4-Quinolones via Mono or Sequential Cross-Couplings

(2010) R. Matthew Cross et al.   JOURNAL OF ORGANIC CHEMISTRY

Survey of Solvents for the Conrad–Limpach Synthesis of 4-Hydroxyquinolones

(2009) Jean-Cristophe Brouet et al.   SYNTHETIC COMMUNICATIONS

Synthesis of a quinolone library from ynones

(2009) Timothy R. Ward et al.   TETRAHEDRON LETTERS

Toxoplasma gondii infection in humans and animals in the United States

(2008) J DUBEY et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Antimalarial quinolones: Synthesis, potency, and mechanistic studies

(2007) Rolf W. Winter et al.   EXPERIMENTAL PARASITOLOGY