Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2

(2020) Chunjian Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A highly efficient and recyclable NiCl2(dppp)/PEG-400 system for Suzuki-Miyaura reaction of aryl chlorides with arylboronic acids

(2019) Yang Liao et al.   SYNTHETIC COMMUNICATIONS

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

(2019) Stephen T. Wrobleski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bis(dialkylphosphino)ferrocene-Ligated Nickel(II) Precatalysts for Suzuki–Miyaura Reactions of Aryl Carbonates

(2019) Emily L. Barth et al.   ORGANOMETALLICS

(DPEPhos)Ni(mesityl)Br: An Air-Stable Pre-Catalyst for Challenging Suzuki–Miyaura Cross-Couplings Leading to Unsymmetrical Biheteroaryls

(2018) Mark Stradiotto et al.   SYNLETT

Taming Nickel-Catalyzed Suzuki-Miyaura Coupling: A Mechanistic Focus on Boron-to-Nickel Transmetalation

(2018) Pierre-Adrien Payard et al.   ACS Catalysis

Advances in Base-Metal Catalysis: Development of a Screening Platform for Nickel-Catalyzed Borylations of Aryl (Pseudo)halides with B2(OH)4

(2018) John R. Coombs et al.   ORGANOMETALLICS

Ni-Catalyzed Cross-Coupling of Dimethyl Aryl Amines with Arylboronic Esters under Reductive Conditions

(2018) Zhi-Chao Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis

(2018) John D. Hayler et al.   ORGANOMETALLICS

Structural, Kinetic, and Computational Characterization of the Elusive Arylpalladium(II)boronate Complexes in the Suzuki–Miyaura Reaction

(2017) Andy A. Thomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Study of an Improved Ni Precatalyst for Suzuki–Miyaura Reactions of Aryl Sulfamates: Understanding the Role of Ni(I) Species

(2017) Megan Mohadjer Beromi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toxicity of Metal Compounds: Knowledge and Myths

(2017) Ksenia S. Egorova et al.   ORGANOMETALLICS

Thieme Chemistry Journals Awardees – Where Are They Now? Efficient Cross-Coupling of Secondary Amines/Azoles and Activated (Hetero)Aryl Chlorides Using an Air-Stable DPEPhos/Nickel Pre-Catalyst

(2017) Mark Stradiotto et al.   SYNLETT

High-Throughput Automation in Chemical Process Development

(2017) Joshua A. Selekman et al.   Annual Review of Chemical and Biomolecular Engineering

Synthesis of Biaryls through Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides by Carbon-Nitrogen Bond Cleavage

(2016) Shicheng Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Which Metals are Green for Catalysis? Comparison of the Toxicities of Ni, Cu, Fe, Pd, Pt, Rh, and Au Salts

(2016) Ksenia S. Egorova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protodeboronation of Heteroaromatic, Vinyl, and Cyclopropyl Boronic Acids: pH–Rate Profiles, Autocatalysis, and Disproportionation

(2016) Paul A. Cox et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparison of dppf-Supported Nickel Precatalysts for the Suzuki-Miyaura Reaction: The Observation and Activity of Nickel(I)

(2015) Louise M. Guard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ni-catalyzed Suzuki–Miyaura coupling reactions of pyrimidin-2-yl phosphates, tosylates and pivalates with arylboronic acids

(2015) Ting Xing et al.   TETRAHEDRON LETTERS

Nickel- and Palladium-Catalyzed Coupling of Aryl Fluorosulfonates with Aryl Boronic Acids Enabled by Sulfuryl Fluoride

(2015) Patrick S. Hanley et al.   ACS Catalysis

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiocarbamates: Reagents for the Removal of Transition Metals from Organic Reaction Media

(2014) William P. Gallagher et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Transition-metal-catalyzed Suzuki–Miyaura cross-coupling reactions: a remarkable advance from palladium to nickel catalysts

(2013) Fu-She Han   CHEMICAL SOCIETY REVIEWS

Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki-Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides

(2012) Shaozhong Ge et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

(2011) Javier Magano et al.   CHEMICAL REVIEWS

Suzuki−Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates: Experimental and Computational Studies

(2011) Kyle W. Quasdorf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Suzuki–Miyaura Reaction of Aryl Fluorides

(2011) Mamoru Tobisu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds

(2010) Brad M. Rosen et al.   CHEMICAL REVIEWS