Journal
ORGANIC LETTERS
Volume 23, Issue 20, Pages 7718-7723Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02646
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Funding
- NSFC [21871093]
- STCSM [20ZR1417600]
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This study demonstrates that three types of trifluoromethylated pyrazolidines, pyrazolines, and pyrazoles can be synthesized by the divergent reaction of beta-CF3-1,3-enyne with various hydrazines.
Three types of trifluoromethylated pyrazolidines, pyrazolines, and pyrazoles can be synthesized via divergent reaction of beta-CF3-1, 3-enyne with hydrazines. The reaction with simple hydrazine monohydrate or sulfonyl hydrazines as nucleophiles produces 1,3,4-trisubstituted pyrazolines, whereas the reaction with acetyl hydrazine as nucleophiles affords 1,4,5-trisubstituted pyrazolidines. Using phenylhydrazine or tertbutylhydrazine as a reaction partner, the products are easily oxidized to form 1,4,5-trisubstituted pyrazoles.
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