Journal
FUTURE MICROBIOLOGY
Volume 11, Issue 10, Pages 1359-1369Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2016-0081
Keywords
bacteriophage; interaction; microbiome; periodontitis; therapy
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Funding
- Portuguese Foundation for Science and Technology (FCT) [UID/BIO/04469/2013, POCI-01-0145-FEDER-006684, RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462)]
- TecMinho [TecMinho 045/TT/2014]
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The human periodontium health is commonly compromised by chronic inflammatory conditions and has become a major public health concern. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect bacteria - bacteriophages - are most common in the oral cavity. Despite this, their role in the progression of periodontal disease remains poorly explored. This review aims to summarize how bacteriophages interact with the oral microbiota, their ability to increase bacterial virulence and mediate the transfer of resistance genes and suggests how bacteriophages can be used as an alternative to the current periodontal disease therapies.
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