Journal
ONCOGENE
Volume 40, Issue 29, Pages 4737-4745Publisher
SPRINGERNATURE
DOI: 10.1038/s41388-021-01918-y
Keywords
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Funding
- National Natural Science Foundation of China [82025016, 31830025, 81901585]
- Natural Science Foundation of Guangdong Province, China [2018B030308010, 2019A1515011770, 2020A1515010895]
- China Postdoctoral Science Foundation [2020T130738, 2019M653191, 2019M653169, BX20180398]
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B cells in tumors exhibit heterogeneity in subset composition, influencing disease progression differently. The interactions between B cells and other immune cells in the tumor microenvironment play a crucial role in regulating B cell differentiation and function in situ. Understanding the complex nature of B cell subsets and related immune network in tumors is essential for better cancer immunotherapies.
B cells constitute a major component of tumor-infiltrating leukocytes. However, the influence of these cells on malignancy is currently under debate, reflecting the heterogeneity of B cell subsets in tumors. With recent advances, it becomes apparent that this debate includes not only the evaluation of B cells themselves, but also the underlying immune microenvironment network, which scripts the highly heterogeneous B cell populations in tumors and directs the roles of those sub-populations in disease progression and clinical treatment. In this review, we summarize recent findings on the heterogeneous subset composition of B cells in both human and mouse tumor models and their different impacts on disease progression. We further describe the multidimensional interplays between B cells and other immune cells in the tumor microenvironment, which account for the regulation of B cell differentiation and function in situ. We also assess the potential influences of distinct sub-tumor locations on B cell function in primary tumors during development and those under immunotherapy treatment. Illuminating the heterogeneous nature of B cell subset composition, generation, localization, and related immune network in tumor is of immense significance for comprehensively understanding B cell response in tumor and designing more efficacious cancer immunotherapies.
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