Porcine circovirus 2 capsid protein produced in N. benthamiana forms virus-like particles that elicit production of virus-neutralizing antibodies in guinea pigs

First human efficacy study of a plant-derived influenza vaccine

(2020) John S Tregoning   LANCET

Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials

(2020) Brian J Ward et al.   LANCET

Immunogenicity of plant-produced porcine circovirus-like particles in mice

(2019) Cornelius J. Gunter et al.   PLANT BIOTECHNOLOGY JOURNAL

Development of Recombinant Protein-Based Vaccine Against Classical Swine Fever Virus in Pigs Using Transgenic Nicotiana benthamiana

(2019) Youngmin Park et al.   Frontiers in Plant Science

Phylogeographic and genetic characterization of porcine circovirus type 2 in Taiwan from 2001–2017

(2019) Guang-Ting Tsai et al.   Scientific Reports

Recent progress on porcine circovirus type 3

(2019) Ting Ouyang et al.   INFECTION GENETICS AND EVOLUTION

Proteases of Nicotiana benthamiana: an emerging battle for molecular farming

(2019) Philippe V Jutras et al.   CURRENT OPINION IN BIOTECHNOLOGY

Plant-made E2 glycoprotein single-dose vaccine protects pigs against classical swine fever

(2018) Richard C. Laughlin et al.   PLANT BIOTECHNOLOGY JOURNAL

Purification and characterization of Arabidopsis thaliana oligosaccharyltransferase complexes from the native host: a protein super-expression system for structural studies

(2018) In Sil Jeong et al.   PLANT JOURNAL

Development of Plant-produced E2 Protein for Use as a Green Vaccine Against Classical Swine Fever Virus

(2018) Eun-Ju Sohn et al.   JOURNAL OF PLANT BIOLOGY

Cost‐effective production of tag‐less recombinant protein in Nicotiana benthamiana

(2018) Md Reyazul Islam et al.   PLANT BIOTECHNOLOGY JOURNAL

A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naïve pigs under experimental conditions

(2017) Tanja Opriessnig et al.   VACCINE

Porcine Circovirus Type 2 (PCV2) Vaccines in the Context of Current Molecular Epidemiology

(2017) Anbu Karuppannan et al.   Viruses-Basel

Plant-made vaccines and reagents for the One Health initiative

(2017) Edward Peter Rybicki   Human Vaccines & Immunotherapeutics

A Perspective on the Development of Plant-Made Vaccines in the Fight against Ebola Virus

(2017) Sergio Rosales-Mendoza et al.   Frontiers in Immunology

Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives

(2017) Lilya Kopertekh et al.   CURRENT MEDICINAL CHEMISTRY

Vaccination via Chloroplast Genetics: Affordable Protein Drugs for the Prevention and Treatment of Inherited or Infectious Human Diseases

(2016) Henry Daniell et al.   Annual Review of Genetics

Techno-economic analysis of a transient plant-based platform for monoclonal antibody production

(2016) Somen Nandi et al.   mAbs

Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment

(2016) G. P. Lomonossoff et al.   SCIENCE

2.9 Å Resolution Cryo-EM 3D Reconstruction of Close-Packed Virus Particles

(2016) Zheng Liu et al.   STRUCTURE

Interactions of porcine circovirus 2 with its hosts

(2016) Linzhu Ren et al.   VIRUS GENES

The ORF3 protein of porcine circovirus type 2 promotes secretion of IL-6 and IL-8 in porcine epithelial cells by facilitating proteasomal degradation of regulator of G protein signalling 16 through physical interaction

(2015) Chang-Yong Choi et al.   JOURNAL OF GENERAL VIROLOGY

Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms the presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d

(2015) Chao-Ting Xiao et al.   JOURNAL OF GENERAL VIROLOGY

Genetic characterisation of Porcine circovirus type 2 (PCV2) strains from feral pigs in the Brazilian Pantanal: An opportunity to reconstruct the history of PCV2 evolution

(2015) Giovanni Franzo et al.   VETERINARY MICROBIOLOGY

Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks

(2014) Maite Sabalza et al.   BIOTECHNOLOGY LETTERS

Best practice and future challenges for vaccination against porcine circovirus type 2

(2014) Joaquim Segalés   Expert Review of Vaccines

N-linked protein glycosylation in the ER

(2013) Markus Aebi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The immediate upstream region of the 5′-UTR from the AUG start codon has a pronounced effect on the translational efficiency in Arabidopsis thaliana

(2013) Younghyun Kim et al.   NUCLEIC ACIDS RESEARCH

Cost of post-weaning multi-systemic wasting syndrome and porcine circovirus type-2 subclinical infection in England – An economic disease model

(2013) Pablo Alarcon et al.   PREVENTIVE VETERINARY MEDICINE

Antibody Recognition of Porcine Circovirus Type 2 Capsid Protein Epitopes after Vaccination, Infection, and Disease

(2011) Benjamin R. Trible et al.   Clinical and Vaccine Immunology

Porcine circovirus type 2 (PCV2) infections: Clinical signs, pathology and laboratory diagnosis

(2011) Joaquim Segalés   VIRUS RESEARCH

Genetic variation of porcine circovirus type 2 (PCV2) and its relevance to vaccination, pathogenesis and diagnosis

(2011) Benjamin R. Trible et al.   VIRUS RESEARCH

Novel chimeric porcine circovirus (PCV) with the capsid gene of the emerging PCV2b subtype cloned in the genomic backbone of the non-pathogenic PCV1 is attenuated in vivo and induces protective and cross-protective immunity against PCV2b and PCV2a subtypes in pigs

(2010) Nathan M. Beach et al.   VACCINE

Genotypic shift of porcine circovirus type 2 from PCV-2a to PCV-2b in Spain from 1985 to 2008

(2010) M. Cortey et al.   VETERINARY JOURNAL

Porcine circovirus type 2 (PCV2): genetic variation and newly emerging genotypes in China

(2010) Long J Guo et al.   Virology Journal

The HSP Terminator of Arabidopsis thaliana Increases Gene Expression in Plant Cells

(2009) Shingo Nagaya et al.   PLANT AND CELL PHYSIOLOGY

One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model

(2009) M. Fort et al.   VACCINE

Porcine circoviruses—Small but powerful

(2009) Tim Finsterbusch et al.   VIRUS RESEARCH

A model ofAgrobacterium tumefaciensvacuum infiltration into harvested leaf tissue and subsequent in planta transgene transient expression

(2008) Christopher W. Simmons et al.   BIOTECHNOLOGY AND BIOENGINEERING

Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case–control study supports a shift in genotypes with time

(2007) K. Dupont et al.   VETERINARY MICROBIOLOGY