Ventral pallidum cellular and pathway specificity in drug seeking

Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption

(2021) Yvan M. Vachez et al.   NATURE NEUROSCIENCE

Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking

(2021) Horia Pribiag et al.   NEURON

Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors

(2020) Marcus Stephenson-Jones et al.   NEURON

Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum

(2020) Jasper A. Heinsbroek et al.   Cell Reports

Dissociable roles of ventral pallidum neurons in the basal ganglia reinforcement learning network

(2020) Alexander Kaplan et al.   NATURE NEUROSCIENCE

Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors

(2020) Frederic W. Hopf   NEUROPHARMACOLOGY

A quantitative reward prediction error signal in the ventral pallidum

(2020) David J. Ottenheimer et al.   NATURE NEUROSCIENCE

Improving translation of animal models of addiction and relapse by reverse translation

(2020) Marco Venniro et al.   NATURE REVIEWS NEUROSCIENCE

Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet

(2020) Shani Gendelis et al.   JOURNAL OF NEUROSCIENCE

Ventral pallidum is the primary target for accumbens D1 projections driving cocaine seeking

(2019) Thibaut R. Pardo-Garcia et al.   JOURNAL OF NEUROSCIENCE

Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia and Negative Reinforcement

(2019) George F. Koob   BIOLOGICAL PSYCHIATRY

Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil

(2019) Aida Mohammadkhani et al.   BRAIN RESEARCH

Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats

(2019) Mitchell R. Farrell et al.   NEUROPSYCHOPHARMACOLOGY

The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens

(2019) Corey Baimel et al.   Cell Reports

Orexin-1 Receptor Signaling in Ventral Pallidum Regulates Motivation for the Opioid Remifentanil

(2019) Aida Mohammadkhani et al.   JOURNAL OF NEUROSCIENCE

Mapping excessive “disgust” in the brain: Ventral pallidum inactivation recruits distributed circuitry to make sweetness “disgusting”

(2019) Hammad A. Khan et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Complementary Roles for Ventral Pallidum Cell Types and Their Projections in Relapse

(2019) Asheeta A. Prasad et al.   JOURNAL OF NEUROSCIENCE

Projection-Specific Potentiation of Ventral Pallidal Glutamatergic Outputs after Abstinence from Cocaine

(2019) Liran A. Levi et al.   JOURNAL OF NEUROSCIENCE

Cocaine Dysregulates Dynorphin Modulation of Inhibitory Neurotransmission in the Ventral Pallidum in a Cell-Type-Specific Manner

(2019) Kineret Inbar et al.   JOURNAL OF NEUROSCIENCE

Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding

(2019) Hao Li et al.   NEURON

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

(2018) Jessica Tooley et al.   BIOLOGICAL PSYCHIATRY

Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET Binding in Tobacco Smokers

(2018) Patricia Di Ciano et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking

(2018) Gabrielle D. Gibson et al.   NEURON

Neuropeptide modulation of addiction: Focus on galanin

(2018) Shannyn G. Genders et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Context-induced relapse after extinction versus punishment: similarities and differences

(2018) Nathan J. Marchant et al.   PSYCHOPHARMACOLOGY

Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum

(2018) Lauren Faget et al.   Nature Communications

Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin

(2018) Aya Matsui et al.   Cell Reports

Novel models of drug relapse and craving after voluntary abstinence

(2018) Marco Venniro et al.   NEUROPSYCHOPHARMACOLOGY

Amphetamine Self-Administration and Its Extinction Alter the 5-HT1B Receptor Protein Levels in Designated Structures of the Rat Brain

(2018) Joanna Miszkiel et al.   NEUROTOXICITY RESEARCH

Ventral pallidal modulation of aversion processing

(2018) Andreas B. Wulff et al.   BRAIN RESEARCH

Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens

(2018) David Ottenheimer et al.   Nature Communications

Neural circuit adaptations during drug withdrawal — Spotlight on the lateral habenula

(2017) Frank J. Meye et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeting the subthalamic nucleus in a preclinical model of alcohol use disorder

(2017) Yann Pelloux et al.   PSYCHOPHARMACOLOGY

Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice

(2016) Kristen A. Stout et al.   ACS Chemical Neuroscience

Arborization patterns of amygdalopetal axons from the rat ventral pallidum

(2016) S. Mongia et al.   Brain Structure & Function

How contexts promote and prevent relapse to drug seeking

(2016) S. Y.-S. Khoo et al.   GENES BRAIN AND BEHAVIOR

Npas1+ Pallidal Neurons Target Striatal Projection Neurons

(2016) K. E. Glajch et al.   JOURNAL OF NEUROSCIENCE

Neural Activity in the Ventral Pallidum Encodes Variation in the Incentive Value of a Reward Cue

(2016) Allison M. Ahrens et al.   JOURNAL OF NEUROSCIENCE

Ventral Pallidum Output Pathways in Context-Induced Reinstatement of Alcohol Seeking

(2016) Asheeta A. Prasad et al.   JOURNAL OF NEUROSCIENCE

Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking

(2016) Jasper A. Heinsbroek et al.   JOURNAL OF NEUROSCIENCE

Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions

(2016) Jocelyn M. Richard et al.   NEURON

Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum

(2016) Meaghan Creed et al.   NEURON

The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think

(2016) Yonatan M Kupchik et al.   NEUROPSYCHOPHARMACOLOGY

Role of the striatopallidal pathway in renewal and reacquisition of alcohol seeking.

(2015) Audrey T. Khoo et al.   BEHAVIORAL NEUROSCIENCE

Positive reinforcing effect of neurotensin microinjection into the ventral pallidum in conditioned place preference test

(2015) Tamás Ollmann et al.   BEHAVIOURAL BRAIN RESEARCH

Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior

(2015) Michael T. Stefanik et al.   Brain Structure & Function

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

(2015) Kevin T. Beier et al.   CELL

Ventral Pallidal Projections to Mediodorsal Thalamus and Ventral Tegmental Area Play Distinct Roles in Outcome-Specific Pavlovian-Instrumental Transfer

(2015) B. K. Leung et al.   JOURNAL OF NEUROSCIENCE

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

(2015) Yonatan M Kupchik et al.   NATURE NEUROSCIENCE

Pleasure Systems in the Brain

(2015) Kent C. Berridge et al.   NEURON

Dynorphin, Dysphoria and Dependence: the Stress of Addiction

(2015) Charles Chavkin et al.   NEUROPSYCHOPHARMACOLOGY

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

(2015) David H. Root et al.   PROGRESS IN NEUROBIOLOGY

Enhanced Extracellular Glutamate and Dopamine in the Ventral Pallidum of Alcohol-Preferring AA and Alcohol-Avoiding ANA Rats after Morphine

(2015) Heidi Kemppainen et al.   Frontiers in Psychiatry

The reinforcing effects of ethanol within the posterior ventral tegmental area depend on dopamine neurotransmission to forebrain cortico-limbic systems

(2014) Zheng-Ming Ding et al.   ADDICTION BIOLOGY

GABAergic and glutamatergic efferents of the mouse ventral tegmental area

(2014) Seth R. Taylor et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cocaine Dysregulates Opioid Gating of GABA Neurotransmission in the Ventral Pallidum

(2014) Yonatan M. Kupchik et al.   JOURNAL OF NEUROSCIENCE

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

Glutamate neurons within the midbrain dopamine regions

(2014) M. Morales et al.   NEUROSCIENCE

Effects of Vivo Morpholino Knockdown of Lateral Hypothalamus Orexin/Hypocretin on Renewal of Alcohol Seeking

(2014) Asheeta A. Prasad et al.   PLoS One

Accumbal and pallidal dopamine, glutamate and GABA overflow during cocaine self-administration and its extinction in rats

(2013) Karolina Wydra et al.   ADDICTION BIOLOGY

Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system

(2013) Erika Gyengesi et al.   BRAIN RESEARCH BULLETIN

A role for the ventral pallidum in context-induced and primed reinstatement of alcohol seeking

(2013) Christina J. Perry et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Optogenetic Evidence That Pallidal Projections, Not Nigral Projections, from the Nucleus Accumbens Core Are Necessary for Reinstating Cocaine Seeking

(2013) M. T. Stefanik et al.   JOURNAL OF NEUROSCIENCE

Opioid Modulation of Ventral Pallidal Afferents to Ventral Tegmental Area Neurons

(2013) G. O. Hjelmstad et al.   JOURNAL OF NEUROSCIENCE

Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use

(2013) Roland Bock et al.   NATURE NEUROSCIENCE

An Orexin Hotspot in Ventral Pallidum Amplifies Hedonic ‘Liking’ for Sweetness

(2013) Chao-Yi Ho et al.   NEUROPSYCHOPHARMACOLOGY

Prelimbic Cortex and Ventral Tegmental Area Modulate Synaptic Plasticity Differentially in Nucleus Accumbens During Cocaine-Reinstated Drug Seeking

(2013) Hao-wei Shen et al.   NEUROPSYCHOPHARMACOLOGY

The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding

(2013) J. H. Jennings et al.   SCIENCE

Optogenetic inhibition of cocaine seeking in rats

(2012) Michael T. Stefanik et al.   ADDICTION BIOLOGY

The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: an electrophysiological study

(2012) Yonatan M. Kupchik et al.   Brain Structure & Function

Axonal branching patterns of ventral pallidal neurons in the rat

(2012) Anushree Tripathi et al.   Brain Structure & Function

Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell

(2012) Ryan T. LaLumiere et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse

(2012) James T. McKenna et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Ventral Tegmental Area Glutamate Neurons: Electrophysiological Properties and Projections

(2012) T. S. Hnasko et al.   JOURNAL OF NEUROSCIENCE

Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry

(2012) M.E. Haahr et al.   NEUROIMAGE

The Primate Ventral Pallidum Encodes Expected Reward Value and Regulates Motor Action

(2012) Yoshihisa Tachibana et al.   NEURON

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens

(2012) S. Yawata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for ventral pallidal GABAergic mechanisms in the regulation of ethanol self-administration

(2012) Heidi Kemppainen et al.   PSYCHOPHARMACOLOGY

Subpopulations of somatostatin-immunoreactive non-pyramidal neurons in the amygdala and adjacent external capsule project to the basal forebrain: evidence for the existence of GABAergic projection neurons in the cortical nuclei and basolateral nuclear complex

(2012) Alexander J. McDonald et al.   Frontiers in Neural Circuits

Opioidergic Modulation of Ethanol Self-Administration in the Ventral Pallidum

(2011) Heidi Kemppainen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Slow phasic and tonic activity of ventral pallidal neurons during cocaine self-administration

(2011) David H. Root et al.   SYNAPSE

Axonal branching patterns of nucleus accumbens neurons in the rat

(2010) Anushree Tripathi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder

(2010) James W. Murrough et al.   PSYCHOPHARMACOLOGY

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Paraventricular thalamus mediates context-induced reinstatement (renewal) of extinguished reward seeking

(2009) Adam S. Hamlin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism

(2009) Xia Li et al.   NEUROPSYCHOPHARMACOLOGY

Parvalbumin-immunoreactive neurons and GABAergic neurons of the basal forebrain project to the rat basolateral amygdala

(2009) F. Mascagni et al.   NEUROSCIENCE

Ventral pallidum roles in reward and motivation

(2008) Kyle S. Smith et al.   BEHAVIOURAL BRAIN RESEARCH

Fos expression following activation of the ventral pallidum in normal rats and in a model of Parkinson’s Disease: implications for limbic system and basal ganglia interactions

(2008) Michael S. Turner et al.   Brain Structure & Function

Infralimbic Prefrontal Cortex Is Responsible for Inhibiting Cocaine Seeking in Extinguished Rats

(2008) J. Peters et al.   JOURNAL OF NEUROSCIENCE

Neurotensin in the Ventral Pallidum Increases Extracellular  -Aminobutyric Acid and Differentially Affects Cue- and Cocaine-Primed Reinstatement

(2008) M. M. Torregrossa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users

(2008) Paul S. Frankel et al.   NEUROPHARMACOLOGY

Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats

(2008) Rita A. Fuchs et al.   PSYCHOPHARMACOLOGY

The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse

(2007) J.L. Rogers et al.   NEUROSCIENCE