PM2.5 as a potential risk factor for autism spectrum disorder: Its possible link to neuroinflammation, oxidative stress and changes in gene expression

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

Effects of PM2.5 and gases exposure during prenatal and early-life on autism–like phenotypes in male rat offspring

(2020) Baharan Emam et al.   Particle and Fibre Toxicology

Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model

(2020) Benjamin C. Nephew et al.   ENVIRONMENTAL RESEARCH

Gestational Exposure to Particulate Matter 2.5 (PM2.5) Leads to Spatial Memory Dysfunction and Neurodevelopmental Impairment in Hippocampus of Mice Offspring

(2019) Xinrui Zheng et al.   Frontiers in Neuroscience

Maternal exposure to air pollution and risk of autism in children: A systematic review and meta-analysis

(2019) HeeKyoung Chun et al.   ENVIRONMENTAL POLLUTION

Gestational B-vitamin supplementation alleviates PM2.5-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring

(2019) Tingting Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Alterations in plasma cytokine levels in chinese children with autism spectrum disorder

(2018) Chun-Chun Hu et al.   Autism Research

The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study

(2018) Melinda C. Power et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders

(2018) Staci D. Bilbo et al.   EXPERIMENTAL NEUROLOGY

Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice

(2018) S.Y. Yau et al.   NEUROBIOLOGY OF DISEASE

Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice

(2018) Jamie S. Church et al.   NEUROTOXICOLOGY

Immune aberrations in children with Autism Spectrum Disorder: a case-control study from a tertiary care neuropsychiatric hospital in India

(2018) Salah Basheer et al.   PSYCHONEUROENDOCRINOLOGY

Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains

(2018) Julia Y. Ljubimova et al.   Scientific Reports

Functions and dysfunctions of nitric oxide in brain

(2018) Pol Picón-Pagès et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early life exposure to particulate matter air pollution (PM1, PM2.5 and PM10) and autism in Shanghai, China: A case-control study

(2018) Gongbo Chen et al.   ENVIRONMENT INTERNATIONAL

Neurotoxicity of traffic-related air pollution

(2017) Lucio G. Costa et al.   NEUROTOXICOLOGY

Prenatal and postnatal mothering by diesel exhaust PM2.5-exposed dams differentially program mouse energy metabolism

(2017) Minjie Chen et al.   Particle and Fibre Toxicology

Early Postnatal Exposure to Airborne Fine Particulate Matter Induces Autism-like Phenotypes in Male Rats

(2017) Kang Li et al.   TOXICOLOGICAL SCIENCES

Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children

(2017) Jiang Xie et al.   Oncotarget

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

(2017) Arman Javadi et al.   eLife

DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells

(2016) Peter A. Mollica et al.   AMERICAN JOURNAL OF PATHOLOGY

Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models

(2016) Verónica Martínez-Cerdeño   Developmental Neurobiology

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children’s Health Study

(2016) Carrie V. Breton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus

(2016) Ming-Wei Chao et al.   ENVIRONMENTAL TOXICOLOGY

Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice

(2016) S.Y. Yau et al.   NEUROBIOLOGY OF DISEASE

Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome

(2016) Crystal Bostrom et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation

(2016) Wei Zhou et al.   Oncotarget

Effect of Fine Particulate Matter (PM2.5) on Rat Placenta Pathology and Perinatal Outcomes

(2016) Yi Liu et al.   MEDICAL SCIENCE MONITOR

Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice

(2015) Matthew K. Hogan et al.   BEHAVIOURAL BRAIN RESEARCH

Air Pollution and Neuropsychological Development: A Review of the Latest Evidence

(2015) Elisabet Suades-González et al.   ENDOCRINOLOGY

Prenatal polycyclic aromatic hydrocarbon (PAH) exposure, antioxidant levels and behavioral development of children ages 6–9

(2015) Jeanine M. Genkinger et al.   ENVIRONMENTAL RESEARCH

Fine particulate matter and the risk of autism spectrum disorder

(2015) Evelyn O. Talbott et al.   ENVIRONMENTAL RESEARCH

Examining the Role of the Human Hippocampus in Approach-Avoidance Decision Making Using a Novel Conflict Paradigm and Multivariate Functional Magnetic Resonance Imaging

(2015) E. B. O'Neil et al.   JOURNAL OF NEUROSCIENCE

Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD

(2015) Daniela Zantomio et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children

(2014) Wiesław A. Jedrychowski et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

In Utero Exposure to Toxic Air Pollutants and Risk of Childhood Autism

(2014) Ondine S. von Ehrenstein et al.   EPIDEMIOLOGY

The Familial Risk of Autism

(2014) Sven Sandin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

(2014) Laura Spinelli et al.   JOURNAL OF MEDICAL GENETICS

Most genetic risk for autism resides with common variation

(2014) Trent Gaugler et al.   NATURE GENETICS

Neuronal excitation upregulates Tbr1, a high-confidence risk gene of autism, mediating Grin2b expression in the adult brain

(2014) Hsiu-Chun Chuang et al.   Frontiers in Cellular Neuroscience

Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the Children of Nurses’ Health Study II Participants

(2013) Andrea L. Roberts et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Rat lung response to ozone and fine particulate matter (PM2.5) exposures

(2013) Guanghe Wang et al.   ENVIRONMENTAL TOXICOLOGY

Cerebellar Purkinje cell activity drives motor learning

(2013) T D Barbara Nguyen-Vu et al.   NATURE NEUROSCIENCE

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

(2013) S. Ricci et al.   NEUROTOXICITY RESEARCH

Evidence of neurodegeneration in autism spectrum disorder

(2013) Janet K Kern et al.   Translational Neurodegeneration

Global Prevalence of Autism and Other Pervasive Developmental Disorders

(2012) Mayada Elsabbagh et al.   Autism Research

Ambient Air Pollution and Autism in Los Angeles County, California

(2012) Tracy Ann Becerra et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Changed gene expression in brains of mice exposed to traffic in a highway tunnel

(2012) Inge Bos et al.   INHALATION TOXICOLOGY

MeCP2+/− mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder

(2012) Wenlin Liao et al.   NEUROBIOLOGY OF DISEASE

Brain Region-Specific Glutathione Redox Imbalance in Autism

(2012) Abha Chauhan et al.   NEUROCHEMICAL RESEARCH

Microglia and neuronal cell death

(2012) José L. Marín-Teva et al.   Neuron Glia Biology

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Traffic-Related Air Pollution, Particulate Matter, and Autism

(2012) Heather E. Volk et al.   JAMA Psychiatry

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

(2012) S Rose et al.   Translational Psychiatry

Brain structure anomalies in autism spectrum disorder-a meta-analysis of VBM studies using anatomic likelihood estimation

(2011) Thomas Nickl-Jockschat et al.   HUMAN BRAIN MAPPING

Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)–like 2

(2011) Anne M. Fitzpatrick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation

(2011) Hongen Wei et al.   Journal of Neuroinflammation

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

MHCI negatively regulates synapse density during the establishment of cortical connections

(2011) Marian W Glynn et al.   NATURE NEUROSCIENCE

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

(2011) Darren Goffin et al.   NATURE NEUROSCIENCE

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Autism spectrum disorders

(2010) Hadeel Faras et al.   ANNALS OF SAUDI MEDICINE

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Evaluation of Oxidative Stress in Autism: Defective Antioxidant Enzymes and Increased Lipid Peroxidation

(2010) Nagwa A. Meguid et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

(2010) Paul Ashwood et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain growth across the life span in autism: Age-specific changes in anatomical pathology

(2010) Eric Courchesne et al.   BRAIN RESEARCH

Brain Region-Specific Changes in Oxidative Stress and Neurotrophin Levels in Autism Spectrum Disorders (ASD)

(2010) Elizabeth M. Sajdel-Sulkowska et al.   CEREBELLUM

Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism

(2010) M. Wöhr et al.   GENES BRAIN AND BEHAVIOR

Low-grade endotoxemia in patients with severe autism

(2010) Enzo Emanuele et al.   NEUROSCIENCE LETTERS

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability

(2009) Mu Yang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Elevated immune response in the brain of autistic patients

(2009) Xiaohong Li et al.   JOURNAL OF NEUROIMMUNOLOGY

MHC Class I: An Unexpected Role in Neuronal Plasticity

(2009) Carla J. Shatz   NEURON

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice

(2008) Kathryn K. Chadman et al.   Autism Research

Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene.

(2008) Corinne M. Spencer et al.   BEHAVIORAL NEUROSCIENCE

Social approach and repetitive behavior in eleven inbred mouse strains

(2008) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J mice

(2008) Bryce C. Ryan et al.   BEHAVIOURAL BRAIN RESEARCH

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

(2008) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

A new test paradigm for social recognition evidenced by urinary scent marking behavior in C57BL/6J mice

(2008) Hiroyuki Arakawa et al.   BEHAVIOURAL BRAIN RESEARCH

Neurons in the fusiform gyrus are fewer and smaller in autism

(2008) Imke A. J. van Kooten et al.   BRAIN

Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female mice

(2008) Conor M. Stack et al.   EXPERIMENTAL NEUROLOGY

Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism

(2008) Susan E. Swanberg et al.   HUMAN MOLECULAR GENETICS

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

(2008) Charles A. Hoeffer et al.   NEURON

The ‘Fractionable Autism Triad’: A Review of Evidence from Behavioural, Genetic, Cognitive and Neural Research

(2008) Francesca Happé et al.   NEUROPSYCHOLOGY REVIEW

Scent marking behavior as an odorant communication in mice

(2008) Hiroyuki Arakawa et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disorders

(2008) Maria Luisa Scattoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ultrasonic Vocalizations Induced by Sex and Amphetamine in M2, M4, M5 Muscarinic and D2 Dopamine Receptor Knockout Mice

(2008) Haoran Wang et al.   PLoS One

Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells

(2008) E. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR