Safety learning and the Pavlovian conditioned inhibition of fear in humans: Current state and future directions

Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder

(2021) Peiling Zhou et al.   MOLECULAR NEUROBIOLOGY

Verbal threat learning does not spare loved ones

(2021) Cristina Morato et al.   Scientific Reports

A ventral striatal prediction error signal in human fear extinction learning

(2021) M. Thiele et al.   NEUROIMAGE

Safety learning during development: Implications for development of psychopathology

(2021) Lana Ruvolo Grasser et al.   BEHAVIOURAL BRAIN RESEARCH

Aversive Stimulus Pairings Are an Unnecessary and Insufficient Cause of Pathological Anxiety

(2020) Bram Vervliet et al.   BIOLOGICAL PSYCHIATRY

Infralimbic cortex activity is required for the expression but not the acquisition of conditioned safety

(2020) Judith C. Kreutzmann et al.   PSYCHOPHARMACOLOGY

Dopamine: from prediction error to psychotherapy

(2020) Silvia Papalini et al.   Translational Psychiatry

Keep it real: rethinking the primacy of experimental control in cognitive neuroscience

(2020) Samuel A. Nastase et al.   NEUROIMAGE

Measuring learning in human classical threat conditioning: Translational, cognitive and methodological considerations

(2020) Karita E. Ojala et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inconsistent analytic strategies reduce robustness in fear extinction via skin conductance response

(2020) Luke John Ney et al.   PSYCHOPHYSIOLOGY

Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times

(2020) Lili X Cai et al.   eLife

From adaptive to maladaptive fear: Heterogeneity in threat and safety learning across response systems in a representative sample

(2020) Femke J. Gazendam et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample

(2020) Toby Wise et al.   Nature Communications

l-DOPA and consolidation of fear extinction learning among women with posttraumatic stress disorder

(2020) Josh M. Cisler et al.   Translational Psychiatry

Neurophysiological responses to safety signals and the role of cardiac vagal control

(2020) Antonia V. Seligowski et al.   BEHAVIOURAL BRAIN RESEARCH

Pre-adolescent stress disrupts adult, but not adolescent, safety learning

(2020) Heidi C. Meyer et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD

(2020) Luke J. Ney et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dopamine, Updated: Reward Prediction Error and Beyond

(2020) Talia N. Lerner et al.   CURRENT OPINION IN NEUROBIOLOGY

Neural computations of threat in the aftermath of combat trauma

(2019) Philipp Homan et al.   NATURE NEUROSCIENCE

Conditioned inhibition: Historical critiques and controversies in the light of recent advances.

(2019) Rodrigo Sosa et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Role of human ventromedial prefrontal cortex in learning and recall of enhanced extinction

(2019) Joseph E. Dunsmoor et al.   JOURNAL OF NEUROSCIENCE

Fear extinction retention – is it what we think it is?

(2019) Tina B. Lonsdorf et al.   BIOLOGICAL PSYCHIATRY

A Dopaminergic Basis for Fear Extinction

(2019) Raffael Kalisch et al.   TRENDS IN COGNITIVE SCIENCES

Elevated dopamine signaling from ventral tegmental area to prefrontal cortical parvalbumin neurons drives conditioned inhibition

(2019) Rongzhen Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common and distinct neural correlates of fear extinction and cognitive reappraisal: A meta-analysis of fMRI studies

(2019) M. Picó-Pérez et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Anticipatory Threat Responding: Associations with Anxiety, Development, and Brain Structure

(2019) Rany Abend et al.   BIOLOGICAL PSYCHIATRY

Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans

(2019) Heidi C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating the garden of forking paths for data exclusions in fear conditioning research

(2019) Tina B Lonsdorf et al.   eLife

Ventromedial prefrontal cortex activity and pathological worry in generalised anxiety disorder

(2018) E. Via et al.   BRITISH JOURNAL OF PSYCHIATRY

Extinction of Conditioned Fear in Adolescents and Adults: A Human fMRI Study

(2018) Despina E. Ganella et al.   Frontiers in Human Neuroscience

Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour

(2018) Joseph LeDoux et al.   NATURE REVIEWS NEUROSCIENCE

Polymorphisms that affect GABA neurotransmission predict processing of aversive prediction errors in humans

(2018) Irina Baetu et al.   NEUROIMAGE

Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals

(2018) Mary C. Sarlitto et al.   NEUROSCIENCE

The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research

(2018) Andre Pittig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants

(2018) Miquel A. Fullana et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

How do memory systems detect and respond to novelty?

(2018) Alex Kafkas et al.   NEUROSCIENCE LETTERS

Brief, but not prolonged, pauses in the firing of midbrain dopamine neurons are sufficient to produce a conditioned inhibitor

(2018) Chun Yun Chang et al.   JOURNAL OF NEUROSCIENCE

Human Pavlovian fear conditioning conforms to probabilistic learning

(2018) Athina Tzovara et al.   PLoS Computational Biology

Critical evaluation of current data analysis strategies for psychophysiological measures of fear conditioning and extinction in humans

(2018) L.J. Ney et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Associative structure of conditioned inhibition produced by inhibitory perceptual learning treatment

(2018) Cody W. Polack et al.   LEARNING & BEHAVIOR

Biological preparedness and resistance to extinction of skin conductance responses conditioned to fear relevant animal pictures: A systematic review

(2018) Fredrik Åhs et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Latency of skin conductance responses across stimulus modalities

(2018) R. Sjouwerman et al.   PSYCHOPHYSIOLOGY

Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction

(2018) A. M. V. Gerlicher et al.   Nature Communications

Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

(2018) Ximena I Salinas-Hernández et al.   eLife

Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response

(2018) Sanne J.H. van Rooij et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Acquisition and inhibition of conditioned fear is modulated by individual stimulus fear-relevance

(2017) Jörg Neubert et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Human ventromedial prefrontal cortex and the positive affective processing of safety signals

(2017) Ben J. Harrison et al.   NEUROIMAGE

Don’t fear ‘fear conditioning’: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear

(2017) Tina B. Lonsdorf et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neural basis of impaired safety signaling in Obsessive Compulsive Disorder

(2017) Annemieke M. Apergis-Schoute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Depressed Brain: An Evolutionary Systems Theory

(2017) Paul B. Badcock et al.   TRENDS IN COGNITIVE SCIENCES

Extinction Generates Outcome-Specific Conditioned Inhibition

(2016) Vincent Laurent et al.   CURRENT BIOLOGY

Mini-review: Prediction errors, attention and associative learning

(2016) Peter C. Holland et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Posterior insular cortex is necessary for conditioned inhibition of fear

(2016) Allison R. Foilb et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Serotonin 2C receptor antagonist improves fear discrimination and subsequent safety signal recall

(2016) Allison R. Foilb et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neurobiological correlates of distinct post-traumatic stress disorder symptom profiles during threat anticipation in combat veterans

(2016) D. W. Grupe et al.   PSYCHOLOGICAL MEDICINE

Modeling fear-conditioned bradycardia in humans

(2016) Giuseppe Castegnetti et al.   PSYCHOPHYSIOLOGY

A pupil size response model to assess fear learning

(2016) Christoph W. Korn et al.   PSYCHOPHYSIOLOGY

Functional Neuroimaging of Avoidance Habits in Obsessive-Compulsive Disorder

(2015) Claire M. Gillan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Deficient inhibitory processing in trait anxiety: Evidence from context-dependent fear learning, extinction recall and renewal

(2015) J. Haaker et al.   BIOLOGICAL PSYCHOLOGY

UPDATED META-ANALYSIS OF CLASSICAL FEAR CONDITIONING IN THE ANXIETY DISORDERS

(2015) Puck Duits et al.   DEPRESSION AND ANXIETY

Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies

(2015) M A Fullana et al.   MOLECULAR PSYCHIATRY

Arithmetic and local circuitry underlying dopamine prediction errors

(2015) Neir Eshel et al.   NATURE

Representation of retrieval confidence by single neurons in the human medial temporal lobe

(2015) Ueli Rutishauser et al.   NATURE NEUROSCIENCE

Commonly-occurring polymorphisms in the COMT, DRD1 and DRD2 genes influence different aspects of motor sequence learning in humans

(2015) Irina Baetu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Conditioned and extinguished fear modulate functional corticocardiac coupling in humans

(2015) Christian Panitz et al.   PSYCHOPHYSIOLOGY

Effects of Inflammation on Hippocampus and Substantia Nigra Responses to Novelty in Healthy Human Participants

(2014) Neil A Harrison et al.   NEUROPSYCHOPHARMACOLOGY

Fear conditioning of SCR but not the startle reflex requires conscious discrimination of threat and safety

(2014) Dieuwke Sevenster et al.   Frontiers in Behavioral Neuroscience

Fear Extinction and Relapse: State of the Art

(2013) Bram Vervliet et al.   Annual Review of Clinical Psychology

An improved algorithm for model-based analysis of evoked skin conductance responses

(2013) Dominik R. Bach et al.   BIOLOGICAL PSYCHOLOGY

Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective

(2013) Dan W. Grupe et al.   NATURE REVIEWS NEUROSCIENCE

The conditions that promote fear learning: Prediction error and Pavlovian fear conditioning

(2013) Susan Shi Yuan Li et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Development of fear acquisition and extinction in children: Effects of age and anxiety

(2013) Tanja Jovanovic et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Human fear extinction and return of fear using reconsolidation update mechanisms: The contribution of on-line expectancy ratings

(2013) Victor Taylor Warren et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Learning not to Fear: Neural Correlates of Learned Safety

(2013) Eryan Kong et al.   NEUROPSYCHOPHARMACOLOGY

The Impact of State Anxiety on Fear Inhibition

(2013) Betty Liao et al.   Journal of Experimental Psychopathology

Failure of Neural Responses to Safety Cues in Schizophrenia

(2012) Daphne J. Holt et al.   ARCHIVES OF GENERAL PSYCHIATRY

Deficient safety learning characterizes high trait anxious individuals

(2012) Femke J. Gazendam et al.   BIOLOGICAL PSYCHOLOGY

Extinction, generalization, and return of fear: A critical review of renewal research in humans

(2012) Bram Vervliet et al.   BIOLOGICAL PSYCHOLOGY

What's wrong with fear conditioning?

(2012) Tom Beckers et al.   BIOLOGICAL PSYCHOLOGY

No effect of trait anxiety on differential fear conditioning or fear generalization

(2012) David Torrents-Rodas et al.   BIOLOGICAL PSYCHOLOGY

ACUTE STRESS DISORDER VERSUS CHRONIC POSTTRAUMATIC STRESS DISORDER: INHIBITION OF FEAR AS A FUNCTION OF TIME SINCE TRAUMA

(2012) Tanja Jovanovic et al.   DEPRESSION AND ANXIETY

Inhibition of Fear by Learned Safety Signals: A Mini-Symposium Review

(2012) J. P. Christianson et al.   JOURNAL OF NEUROSCIENCE

Exploring a latent cause theory of classical conditioning

(2012) Samuel J. Gershman et al.   LEARNING & BEHAVIOR

Model-based analysis of skin conductance responses: Towards causal models in psychophysiology

(2012) Dominik R. Bach et al.   PSYCHOPHYSIOLOGY

Are Preventive and Generative Causal Reasoning Symmetrical? Extinction and Competition

(2012) Irina Baetu et al.   QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY

Safety Signals Mitigate the Consequences of Uncontrollable Stress Via a Circuit Involving the Sensory Insular Cortex and Bed Nucleus of the Stria Terminalis

(2011) John P. Christianson et al.   BIOLOGICAL PSYCHIATRY

Competition between an avoidance response and a safety signal: Evidence for a single learning system

(2011) Peter F. Lovibond et al.   BIOLOGICAL PSYCHOLOGY

Extinction context as a conditioned inhibitor

(2011) Cody W. Polack et al.   LEARNING & BEHAVIOR

Differential roles of human striatum and amygdala in associative learning

(2011) Jian Li et al.   NATURE NEUROSCIENCE

Impaired safety signal learning may be a biomarker of PTSD

(2011) Tanja Jovanovic et al.   NEUROPHARMACOLOGY

Placing prediction into the fear circuit

(2011) Gavan P. McNally et al.   TRENDS IN NEUROSCIENCES

Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction

(2011) K A Raczka et al.   Translational Psychiatry

A translational bridge between mouse and human models of learned safety

(2010) Daniela D. Pollak et al.   ANNALS OF MEDICINE

Dynamic causal modelling of anticipatory skin conductance responses

(2010) Dominik R. Bach et al.   BIOLOGICAL PSYCHOLOGY

Impaired fear inhibition is a biomarker of PTSD but not depression

(2010) Tanja Jovanovic et al.   DEPRESSION AND ANXIETY

Stimuli that signal the absence of reinforcement are paid more attention than are irrelevant stimuli

(2010) J. C. Dopson et al.   LEARNING & BEHAVIOR

The learned safety paradigm as a mouse model for neuropsychiatric research

(2010) Daniela D Pollak et al.   Nature Protocols

The neural correlates of negative prediction error signaling in human fear conditioning

(2010) V.I. Spoormaker et al.   NEUROIMAGE

Overlapping neural systems mediating extinction, reversal and regulation of fear

(2010) Daniela Schiller et al.   TRENDS IN COGNITIVE SCIENCES

Contingency learning in human fear conditioning involves the ventral striatum

(2009) Tim Klucken et al.   HUMAN BRAIN MAPPING

Posttraumatic stress disorder may be associated with impaired fear inhibition: Relation to symptom severity

(2009) Tanja Jovanovic et al.   PSYCHIATRY RESEARCH

Fear potentiation is associated with hypothalamic–pituitary–adrenal axis function in PTSD

(2009) Tanja Jovanovic et al.   PSYCHONEUROENDOCRINOLOGY

The Brain's Default Network

(2008) Randy L. Buckner et al.   Annals of the New York Academy of Sciences

The Sensory Insular Cortex Mediates the Stress-Buffering Effects of Safety Signals But Not Behavioral Control

(2008) J. P. Christianson et al.   JOURNAL OF NEUROSCIENCE

From Fear to Safety and Back: Reversal of Fear in the Human Brain

(2008) D. Schiller et al.   JOURNAL OF NEUROSCIENCE

An Animal Model of a Behavioral Intervention for Depression

(2008) Daniela D. Pollak et al.   NEURON

The role of the striatum in aversive learning and aversive prediction errors

(2008) M. R Delgado et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

(2008) Kerry Dwan et al.   PLoS One

Consistency and functional specialization in the default mode brain network

(2008) B. J. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA