Article
Cardiac & Cardiovascular Systems
Hasanjan Tiliwaldi, Abdusalam Tursun, Ali Tohti, Mirahmat Mamatzunun, Zukai Wu
Summary: Circular RNA circ_0000345 plays a regulatory role in atherosclerosis (AS) by attenuating oxidized low-density lipoprotein-induced cell damage through modulating the miR-129-5p/TET2 axis.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Huan Wan, Ting You, Wei Luo
Summary: The research indicated that circ_0003204 exacerbated ox-LDL-induced damage in HUVECs by modulating the miR-942-5p/HDAC9 pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Chen Sun, Jinliang Li, Ying Li, Li Li, Guopeng Huang
Summary: This study found that circUBR4 promotes ox-LDL-induced VSMC proliferation and migration by up-regulating FRS2 via miR-185-5p.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
Minghu Zhao, Yuanyuan Yang, Jingchao Li, Min Lu, Yu Wu
Summary: This study investigated the molecular basis of lncRNA OIP5-AS1 in the pathogenesis of atherosclerosis. The results demonstrated that silencing OIP5-AS1 protected against ox-LDL-triggered cytotoxicity in HUVECs by regulating KLF5 expression via acting as a miR-135a-5p sponge. Furthermore, OIP5-AS1 functioned as a molecular sponge of miR-135a-5p to modulate ox-LDL-induced HUVEC injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Guiming Wang, Yudong Yang, Honggang Ma, Liuming Shi, Wenbin Jia, Xing Hao, Weizong Liu
Summary: The study revealed that the FENDRR/miR-18a-5p/PGC-1α signaling pathway regulated mitochondrial energy metabolism in HAECs, with ox-LDL downregulating PGC-1α expression, leading to mitochondrial energy metabolism disorder through pathway inhibition.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chuan Qu, Xin Liu, Xueyu Han, Meng Sun, Haixia Liu, Bo Yang
Summary: Atherosclerosis (AS) is a major cause of cardiovascular disorder. MiR-216b-5p improves the functions of vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs) affected by ox-LDL by inhibiting IGF2, and exerts protective effects to block the development of AS.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Shu-Xin Zhang, Cheng-Hong Yu
Summary: This study reveals the importance of LncRNA UCA1 in cardiovascular diseases, particularly in the development of atherosclerosis. UCA1 regulates endothelial cell dysfunction, apoptosis, pro-inflammatory cytokine production, and oxidative stress through targeting miR-873-5p and its downstream target gene, MAPK8.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cell Biology
Ping Mao, Xiaowei Liu, Yingzheng Wen, Lijiang Tang, Yimin Tang
Summary: SNHG12 promotes the development of AS through the miR-218-5p/IGF2 axis. Experimental results from in vivo and in vitro studies demonstrated that SNHG12 upregulated IGF2 expression, increased the production of inflammatory cytokines, and augmented atherosclerotic lesions.
Article
Surgery
Yu Gao, Jianwei Yue, Zhiliang Huang
Summary: MIAT expression was up-regulated in ox-LDL-induced HUVECs, while knockdown of MIAT promoted cell viability, invasion, migration, EMT, and inhibited apoptosis, as well as the levels of inflammatory factors, affecting the regulation of miR206/RAB22A axis.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ruimei Han, Jian Luo, Lingpeng Wang, Li Li, Hongchao Zheng
Summary: The study revealed that miR-33a-5p suppresses VSMCs calcification stimulated by ox-LDL by targeting METTL3, highlighting the critical role of miR-33a-5p/METTL3 in vascular calcification.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinlei Wu, Tingting Liu, Wenjie Xie, Yufeng Zhuo, Yanling Feng
Summary: This study demonstrates that ox-LDL can activate the SKP2/EP300 pathway through upregulation of miR-21-5p, resulting in acetylation and secretion of HMGB1 outside the endothelium, thus enhancing macrophage polarization and further stabilizing inflammation situation.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hezhong Zhu, Hui Liang, Zhen Gao, Xiaoqiao Zhang, Qian He, Chaoyong He, Chao Cai, Jiajuan Chen
Summary: The study found that downregulation of miR-483-5p alleviated ox-LDL-induced endothelial injury by activating autophagy, which may be related to TIMP2.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Xia Li, Xiaoli Kang, Yali Di, Shuxian Sun, Liming Yang, Bin Wang, Zheng Ji
Summary: In this study, the role of circCHMP5 in AS formation was investigated. Results showed that circCHMP5 was overexpressed in ox-LDL-induced HUVECs and its knockdown promoted cell cycle, proliferation, and angiogenesis while inhibiting apoptosis and inflammation. MiR-532-5p was found to be sponged by circCHMP5 and its inhibition reversed the negative regulation of si-circCHMP5 on ox-LDL-induced HUVECs injury. Furthermore, circCHMP5 was found to upregulate ROCK2 by sponging miR-532-5p. These findings suggest that circCHMP5 may be a potential target for AS treatment.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Urology & Nephrology
Jialing Liu, Yi Li, Lingna Lyu, Liang Xiao, Aliza A. Memon, Xin Yu, Arvin Halim, Shivani Patel, Abdikheyre Osman, Wenqing Yin, Jie Jiang, Said Naini, Kenneth Lim, Aifeng Zhang, Jonathan D. Williams, Ruth Koester, Kevin Z. Qi, Quynh-Anh Fucci, Lai Ding, Steven Chang, Ankit Patel, Yutaro Mori, Advika Chaudhari, Aaron Bao, Jia Liu, Tzong-Shi Lu, Andrew Siedlecki
Summary: This study reveals the regulatory role of miR-218-5p in kidney endothelial progenitor cell migration, which may contribute to the development of therapeutic strategies for microvascular kidney injury.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mingqiang Fan, Yinglong Huang, Kunsheng Li, Xiangxiang Yang, Jing Bai, Qiaoke Si, Zhengfei Peng, Chunwen Jia, Qiangnu Zhang, Ding Tao
Summary: This study investigates the functional role of miR-183-5p/FOXO1 in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs) proliferation/apoptosis imbalance. The results show that miR-183-5p/FOXO1 pathway plays a crucial role in mediating the imbalance. Higher levels of miR-183-5p and reduced FOXO1 are observed in samples from high fat-feeding mice and carotid atherosclerosis patients. The miR-183-5p level is also positively correlated with serum ox-LDL level in patients.