Article
Multidisciplinary Sciences
Larry R. Squire, Jennifer C. Frascino, Charlotte S. Rivera, Nadine C. Heyworth, Biyu J. He
Summary: One-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember. Patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions show intact perceptual learning but impaired memory for the images presented.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Clarissa Hoffman, Jingheng Cheng, Daoyun Ji, Yuri Dabaghian
Summary: Our current understanding of brain rhythms is limited to quantifying their characteristics without exploring their structures. In this study, we utilized two independent approaches to investigate brain wave patterns in different physiological contexts. The measures captured the characteristics and abnormal behaviors of the waves and revealed the coupling between the patterns' dynamics and the animal's location, speed, and acceleration. Overall, our findings offer a complementary mesoscale perspective on brain wave structure, dynamics, and functionality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Peng Ke, Chengjie Zheng, Feng Liu, LinJie Wu, Yijie Tang, Yanqin Wu, Dongdong Lv, Huangli Chen, Lin Qian, Xiaodan Wu, Kai Zeng
Summary: Sleep deprivation leads to memory impairment associated with changes in circadian rhythm-related genes. Seven circadian genes play crucial roles in memory impairment after sleep deprivation. Naive B cells and follicular helper T cells are closely related to sleep deprivation.
Review
Biochemistry & Molecular Biology
Lisa C. Lyons, Yann Vanrobaeys, Ted Abel
Summary: Sleep deprivation has negative impacts on health, affecting memory, cognition, and increasing disease risks. It alters molecular signaling, gene expression, dendritic structure, and protein translation processes. Understanding the multiple levels of gene regulation impacted by sleep deprivation is crucial for developing effective therapeutics.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Behavioral Sciences
Andrew B. Lehr, Arvind Kumar, Christian Tetzlaff, Torkel Hafting, Marianne Fyhn, Tristan M. Stober
Summary: CA2 in the hippocampal region is gaining increased attention for its role in social recognition memory, as well as its broader functions in memory processing. Recent research suggests that CA2 may play a fundamental role in hippocampus-dependent memory processing tasks.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Anesthesiology
Dongsheng Dai, Biqiong Zheng, Zenggui Yu, Shizhu Lin, Yijie Tang, Mengnan Chen, Peng Ke, Chengjie Zheng, Yanqing Chen, Xiaodan Wu
Summary: The study showed that the right stellate ganglion block improved spatial learning and memory dysfunction induced by sleep deprivation in rats by alleviating hippocampal damage. It also decreased inflammation and apoptosis in the hippocampus, highlighting a potentially therapeutic mechanism for addressing cognitive deficits associated with sleep deprivation.
BMC ANESTHESIOLOGY
(2021)
Article
Neurosciences
Afzal Misrani, Sidra Tabassum, Zai-yong Zhang, Shao-hua Tan, Cheng Long
Summary: The study found that urolithin A (UA) can reduce neuroinflammation and improve mitochondrial health, showing therapeutic effects in a sleep deprivation mouse model.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Leyla Sahin, Ozge Selin Cevik, Kenan Cevik, Celal Guven, Eylem Taskin, Sayad Kocahan
Summary: This study investigated the protective effects of mild treadmill exercise on acute sleep deprivation rats, finding that exercise can alleviate memory impairment but there is a lack of correlation between hippocampal gene expression levels and memory impairment.
Review
Behavioral Sciences
Mayuri Shukla, Bruno Vincent
Summary: Methamphetamine abuse can have detrimental effects on various parts of the memory system, including the learning process. The structural similarities between this drug and dopamine can lead to cognitive deficits and potentially trigger neurodegenerative disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Rong-Rong Li, Jie Yan, Hao Chen, Wei-Wei Zhang, Yu-Bo Hu, Jie Zhang, Zhi-An Hu, Yan Xiong, Zhong-Xiang Yao, Bo Hu
Summary: Sleep deprivation causes deficits in memory consolidation. This study found that hippocampal sharp wave ripple oscillations during postlearning sleep predicted the consolidation of conditioned memory. However, sleep-deprived mice showed a loss of this consolidation mechanism, leading to impaired memory. Additionally, altered spike dynamics and overexcitation of specific interneurons during recovery sleep may contribute to sleep deprivation-induced memory deficits.
Article
Biology
Yannan Zhu, Yimeng Zeng, Jingyuan Ren, Lingke Zhang, Changming Chen, Guillen Fernandez, Shaozheng Qin
Summary: Emotional learning enhances retroactive memory for neutral events through rapid neural reactivation and connectivity changes, promoting memory integration.
Article
Psychology
Chloe R. Newbury, Rebecca Crowley, Kathleen Rastle, Jakke Tamminen
Summary: Research shows that both pre-learning and post-learning sleep deprivation have negative effects on memory for newly learned material. The study highlights issues of publication bias and low statistical power in the analyzed studies, emphasizing the need for high-powered, preregistered replications to determine effect sizes more accurately.
PSYCHOLOGICAL BULLETIN
(2021)
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Hui Wang, Yu Liu, Yunbo Sun, Ji Dong, Xinping Xu, Haoyu Wang, Xuelong Zhao, Jing Zhang, Binwei Yao, Li Zhao, Shuchen Liu, Ruiyun Peng
Summary: Long-term exposure to microwaves can result in impaired spatial learning and memory, altered synaptic structure, and differential expression of proteins in hippocampal tissue and serum exosomes.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Geriatrics & Gerontology
Jeremy Ebersole, Gregory Rose, Tore Eid, Kevin Behar, Peter Patrylo
Summary: The age-related decrease in hippocampal metabolism is correlated with cognitive decline. However, the resting state neural metabolism and GLU-GLN cycling may be preserved during aging. Enhanced astroglial metabolism observed in aged cognitively-unimpaired rats may serve as a compensatory change to maintain hippocampus-dependent cognitive function.
NEUROBIOLOGY OF AGING
(2021)