Journal
NATURE IMMUNOLOGY
Volume 22, Issue 9, Pages 1163-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-021-01001-4
Keywords
-
Categories
Funding
- National Institutes of Health [R01 AI034206]
- Irvington-Cancer Research Institute Postdoctoral Fellowship
- Ludwig Center at Memorial Sloan Kettering, Parker Institute for Cancer Immunotherapy (PICI)
- National Cancer Institute Cancer Center [P30 CA08748]
- Bruce Charles Forbes Fellowship
Ask authors/readers for more resources
Regulatory T cells play a crucial role in preventing fatal autoimmune inflammation, exerting their function in settings of established broad-spectrum systemic inflammation, and enabling sustained reset of immune homeostasis.
The immunosuppressive function of regulatory T (T-reg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of T-reg cells results in a fatal autoimmune disease featuring all known types of inflammatory responses with every manifestation stemming from T-reg cell paucity, highlighting a vital function of T-reg cells in preventing fatal autoimmune inflammation. However, a major question remains whether T-reg cells can persist and effectively exert their function in a disease state, where a broad spectrum of inflammatory mediators can either inactivate T-reg cells or render innate and adaptive pro-inflammatory effector cells insensitive to suppression. By reinstating Foxp3 protein expression and suppressor function in cells expressing a reversible Foxp3 null allele in severely diseased mice, we found that the resulting single pool of rescued T-reg cells normalized immune activation, quelled severe tissue inflammation, reversed fatal autoimmune disease and provided long-term protection against them. Thus, T-reg cells are functional in settings of established broad-spectrum systemic inflammation and are capable of affording sustained reset of immune homeostasis. Regulatory T cells are functional in a broad-spectrum systemic autoimmune disease and are capable of suppressing innate and adaptive immune responses, reversing established tissue inflammation and enabling long-term restoration of immunological health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available