Review
Oncology
Eugenia Passaro, Chiara Papulino, Ugo Chianese, Antonella Toraldo, Raffaella Congi, Nunzio Del Gaudio, Maria Maddalena Nicoletti, Rosaria Benedetti, Lucia Altucci
Summary: Autophagy is a crucial intracellular catabolic mechanism involved in cancer, with the potential to either promote or prevent tumorigenesis. HDAC6 serves as a key regulator of autophagy, and inhibitors targeting this enzyme may be used as adjunctive therapy in cancer treatment.
Review
Oncology
Laura Grumetti, Rita Lombardi, Federica Iannelli, Biagio Pucci, Antonio Avallone, Elena Di Gennaro, Alfredo Budillon
Summary: This review focuses on the role of histone deacetylase inhibitors (HDACis) in the metabolism and resistance mechanisms of fluoropyrimidines. Studies have shown that HDACis can enhance the antitumor efficacy of fluoropyrimidines and overcome drug resistance. However, clinical studies have not fully confirmed these observations.
Article
Oncology
Jessica L. Dennison, Hassan Al-Ali, Claude-Henry Volmar, Shaun Brothers, Justin Watts, Claes Wahlestedt, Ines Lohse
Summary: This study identified several epigenetic compounds with high anti-leukemia cell activity in samples from acute myeloid leukemia patients, despite the molecular diversity of the disease, suggesting that AML is predominantly an epigenetic disease and similar epigenetic mechanisms may underlie disease development and progression in all patients.
Review
Biochemistry & Molecular Biology
Eleonora Russo, Andrea Spallarossa, Bruno Tasso, Carla Villa, Chiara Brullo
Summary: Nanotechnology plays a crucial role in modern cancer therapy, improving drug penetration into tumor tissues, extending blood circulation times, reducing side effects, and minimizing drug accumulation in healthy tissues. Developing new nanoparticle systems for small molecule tyrosine kinase inhibitors is essential to enhance drug solubility and reduce toxicity, especially for first-line cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Bo Han, Mengfei Wang, Jiayi Li, Qiushi Chen, Niubing Sun, Xuezhi Yang, Qingwei Zhang
Summary: Many populations worldwide suffer from CNS diseases such as brain tumors, neurodegenerative diseases, and stroke, with a shortage of effective drugs. Histone deacetylases (HDACs) have been extensively studied for their role and therapeutic benefits in the CNS. Recent attention has been given to HDACs as potential drug targets for CNS diseases. This review summarizes the applications of HDACis in CNS diseases and discusses the challenges in developing HDACis with different structures and better blood-brain barrier permeability, in order to promote the development of more effective bioactive HDACis for CNS disease treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Mahdieh Mehrpouri, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: This article outlines the role of epigenetic modulations, particularly histone deacetylases, in hematologic malignancies and their therapeutic potential. Research suggests that HDACs play a significant role in hematopoiesis and the development of blood cancers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Angelica Ferro, Dafni Graikioti, Emre Gezer, Constantinos M. M. Athanassopoulos, Muriel Cuendet
Summary: Although proteasome inhibitors have been used as the main treatment for multiple myeloma, patients often relapse and become resistant to drugs. Combining proteasome and histone deacetylase inhibitors has been found to be more effective, as it enhances anti-myeloma activity and improves patient outcomes. Hybrid molecules that combine the pharmacophores of entinostat and bortezomib have been synthesized and shown to have strong antiproliferative activity in multiple myeloma cells, including those resistant to bortezomib, as well as inhibiting histone deacetylase and proteasome activity.
Article
Chemistry, Multidisciplinary
Marie Kuehne, Henry Lindemann, Christian Grune, Daniel Schroeder, Zoltan Cseresnyes, Maren Godmann, Andreas Koschella, Marc Thilo Figge, Christian Eggeling, Dagmar Fischer, Thomas Heinze, Thorsten Heinzel
Summary: Bio-based nanoparticles (NPs) as drug carriers have rapid cellular uptake, no cytotoxicity, and ability to induce histone H3 hyperacetylation, making them suitable for treating inflammation, sepsis, and cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Maria Serena Roca, Tania Moccia, Federica Iannelli, Cristina Testa, Carlo Vitagliano, Michele Minopoli, Rosa Camerlingo, Giulia De Riso, Rossella De Cecio, Francesca Bruzzese, Mariarosaria Conte, Lucia Altucci, Elena Di Gennaro, Antonio Avallone, Alessandra Leone, Alfredo Budillon
Summary: This study investigated the potential of domatinostat in sensitizing PDAC to standard chemotherapeutic treatment. The results showed that domatinostat can enhance the sensitivity of PDAC to chemotherapy drugs by targeting cancer stem cells and inducing oxidative stress. Mechanistically, domatinostat reduces the expression and function of FOXM1, a transcription factor involved in stemness and DNA repair. The expression of FOXM1 is also correlated with the prognosis of chemotherapy-treated PDAC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Manxiang Wu, Tianxiang Chen, Lianfu Wang, Ozioma Udochukwu Akakuru, Xuehua Ma, Jinshan Xu, Jiapeng Hu, Jia Chen, Qianlan Fang, Aiguo Wu, Qiang Li
Summary: This study developed a core membrane nanoplatform for enhanced treatment of triple-negative breast cancer (TNBC) using biomimetic nanotechnology and tumor microenvironment (TME) responsiveness. The nanoplatform showed precise drug delivery and improved oxygen levels in the tumor, resulting in enhanced chemotherapy/phototherapy. In addition, it exhibited good fluorescence and magnetic resonance imaging performances, enabling image-guided combination tumor therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zude Chen, Xiashuang Wang, Xiaoshuang Yang, Yulong Xu, Yu Yang, Hao Wang, Tao Li, Ping Bai, Gengyang Yuan, Huabiao Chen, Jing Yang, Stephanie A. Fiedler, Robin Striar, Daniela R. Bernales, Robert E. Koegel, Qi Cao, Chongzhao Ran, Bo Xiang, Hong Li, Changning Wang
Summary: The study revealed that treatment with CN133 resulted in a 50% reduction in tumor volume, which was more effective than SAHA treatment. [C-11] Martinostat PET imaging was able to identify early lesions of prostate cancer and monitor the therapeutic effect of CN133 in CRPC. Pharmacological approaches demonstrated that CN133 showed nearly 100-fold efficacy compared to SAHA treatment in cell proliferation, invasion, and migration experiments.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Reproductive Biology
Melayshia Mcfadden, Santosh Kumar Singh, Briana Kinnel, Sooryanarayana Varambally, Rajesh Singh
Summary: This study shows that nanoparticle targeted therapy by planetary ball milling (PBM) can induce apoptosis in high-grade serous ovarian cancer cells, inhibit cell proliferation, and reverse multi-drug resistance (MDR).
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Dermatology
Julie Z. Yi, Jean S. McGee
Summary: Epigenetic modifications such as DNA methylation, histone modification, and microRNA action work together to regulate gene expression, controlling key physiological processes in the skin and immune system. In inflammatory skin diseases like psoriasis and atopic dermatitis, epigenetic alterations play a crucial role in immune activation, T-cell polarization, and keratinocyte dysfunction. Targeting the histone machinery shows promise for the development of new therapies in these skin diseases.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Wenjing Xu, Chunping Ye, Xin Qing, Shengli Liu, Xinyi Lv, Wenjun Wang, Xiaochen Dong, Yewei Zhang
Summary: Multi-target Tyrosine Kinase Inhibitors (MTKIs) have gained significant attention in tumor therapy due to their ability to inhibit tumor cell proliferation. However, their toxicity and drug resistance have limited their clinical application. In recent years, nano pharmaceutical technology has been used to deliver MTKIs through various types of nanocarriers, overcoming drug resistance and improving therapeutic efficiency.
MATERIALS TODAY BIO
(2022)
Article
Biophysics
Mai A. Atallah, Marwa A. Sallam, Mona A. Abdelmoneem, Mohamed Teleb, Kadria A. Elkhodairy, Adnan A. Bekhit, Asmaa F. Khafaga, Ahmed E. Noreldin, Ahmed O. Elzoghby, Sherine N. Khattab
Summary: The use of self-assembled nanogels for the co-delivery of therapeutic molecules offers an effective and safe strategy for breast cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Ahmed O. Elzoghby, Cristina R. Ferrone, Soldano Ferrone, Mahmoud L. Nasr
Summary: Pancreatic cancer is a highly aggressive and resistant type of cancer. This review highlights the recent advances in engineering nanomedicines to enhance the immune response against pancreatic cancer. Nanomedicines are used to increase the immunogenicity of cancer cells, deactivate cancer-associated fibroblasts, enhance the antigen-presenting capacity of dendritic cells, reverse the immunosuppressive nature of the tumor microenvironment, and improve the infiltration of cytotoxic T lymphocytes for efficient antitumor immune responses.
DRUG DISCOVERY TODAY
(2023)
Article
Polymer Science
Osama R. M. Metawea, Mohamed Teleb, Nesreen S. Haiba, Ahmed O. Elzoghby, Asmaa F. Khafaga, Ahmed E. Noreldin, Sherine N. Khattab, Hosam H. Khalil
Summary: A smart carrier, PNIPAM-MD NGs, decorated with FA, was developed for efficient delivery of RSV in breast cancer treatment. The FA-PNIPAM-MD F3 NGs displayed dual thermo-and pH-responsivities, high drug-loading capacity, and excellent stability. In vitro and in vivo evaluations demonstrated significant anti-breast cancer potency and tumor growth suppression.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Riham M. Abdelgalil, Sherine N. Khattab, Shaker Ebrahim, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Marwa A. Sallam, Ahmed O. Elzoghby
Summary: Researchers have developed a biocompatible silk-sericin-tagged inorganic nano-hybrid for the treatment and imaging of cancer cells. This nanocarrier can prevent premature release of the chemotherapeutic drug, enhance the stability of layered double hydroxides, and maintain the luminescence properties of zinc oxide quantum dots.
Article
Chemistry, Multidisciplinary
Tasneem A. Nasser, Rawan Adel, Abdelrahman Badr, Mohamed Teleb, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed S. Abdelhamid, Ahmed O. Elzoghby
Summary: Cancer is a major cause of death worldwide, and delayed diagnosis leads to decreased survival rates. Immunotherapy has revolutionized the treatment of various cancers, but many patients do not respond and experience severe immune-related side effects. Recent advances in nanomedicine and imaging have provided new approaches to improving the safety and efficacy of immunotherapy. The field of theranostics, which integrates diagnosis and therapy, shows promising results in animal studies by using nanoparticles. This article discusses the latest developments in nanotheranostics for tumor imaging and cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Yomna M. Elmorshedy, Mohamed Teleb, Marwa A. Sallam, Kadria A. Elkhodairy, Mohammed Bahey-El-Din, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Shimaa A. H. Abdel Monaim, Adnan A. Bekhit, Ahmed O. Elzoghby, Fernando Albericio, Sherine N. Khattab
Summary: Despite progress in targeted therapies, there is a need for convenient therapeutics for colorectal cancer (CRC). Lactoferrin nanoparticles (Lf NPs) show promise in cancer therapy, but their oral delivery is hindered by obstacles such as instability and premature uptake. Microencapsulation of Lf NPs provides a solution by protecting them and improving drug release in the colon.
Review
Pharmacology & Pharmacy
Karim Abdelazim, Amr Ghit, Dina Assal, Neamat Dorra, Nehad Noby, Sherine N. Khattab, Shaymaa Essam El Feky, Ahmed Hussein
Summary: Astaxanthin (AXT) is a natural red fat-soluble pigment occurring in aquatic animals, plants, and microorganisms, and can also be artificially synthesized. AXT has shown potential in scavenging free radicals and has been studied for its efficacy in various diseases. However, its limited solubility, stability, and bioavailability have hindered its therapeutic application. Incorporating AXT with nanocarriers has shown promise in improving its properties. This review summarizes recent data on AXT production, characterization, biological activity, and therapeutic usage, with a focus on its applications in nanotechnology era.
PHARMACOLOGICAL REPORTS
(2023)
Correction
Pharmacology & Pharmacy
Karim Abdelazim, Amr Ghit, Dina Assal, Neamat Dorra, Nehad Noby, Sherine N. Khattab, Shaymaa Essam El Feky, Ahmed Hussein
PHARMACOLOGICAL REPORTS
(2023)
Article
Infectious Diseases
Eglal I. Amer, Sonia R. Allam, Aceel Y. Hassan, Esmail M. El-Fakharany, Mona M. Agwa, Sherine N. Khattab, Eman Sheta, Marwa H. El-Faham
Summary: This study proposes a novel antibody-targeted nano-sized conjugated linoleic acid (CLA) delivery system for the treatment of Schistosoma mansoni infection and control of its transmission. The antibody-conjugated CLA nanomicelles showed significant schistosomicidal and anti-pathology activities against early and late stages of infection in a mouse model. The study highlights the potential of nanotechnology-based immunotherapy for parasitic infections and suggests that the immunodominant reactivity of the anti-SmI serum merits attention as a therapeutic candidate.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Ahmed O. Elzoghby, Omar Samir, Ahmed Soliman, Sergey Solomevich, Minzhi Yu, Anna Schwendeman, Mahmoud L. Nasr
Summary: Engineering biocompatible HDL nanodiscs have gained significant interest in recent years for their applications in drug delivery and structural biology. Nanodiscs offer advantages such as small size, extended circulation time, high stability, good tolerability, and tissue targeting properties. However, there are challenges in isolating and purifying endogenous HDL as well as concerns about safety and production associated with converting HDL into nanoscale therapeutics. In addition to drug delivery, nanodiscs also have the potential for better investigation of virus-receptor interactions and characterization of membrane proteins. Recent advancements, such as using recombinant ApoA1 proteins and ApoA1 mimetic peptides, offer alternatives to endogenous HDL. Overall, nanodiscs show promise for clinical translation and future applications.
Article
Biochemistry & Molecular Biology
Christine A. Morcos, Sherine N. Khattab, Nesreen S. Haiba, Rafik W. Bassily, Marwa M. Abu-Serie, Mohamed Teleb
Summary: This study reports new hybrid triazines capable of simultaneously inhibiting MMP-10/13 and inducing ferroptosis. Preliminary screening revealed outstanding anticancer activity for certain compounds, which depleted cellular GSH, induced lipid peroxidation, and triggered ferroptosis. These findings contribute to a better understanding of the role of MMPs in tumor development and provide new insights for the development of novel combination therapy strategies.
BIOORGANIC CHEMISTRY
(2023)
Meeting Abstract
Oncology
Ahmed Elzoghby, May Freag, Mostafa Mohammed, Krishna Maremanda, Hae Lin Jang, Shiladitya Sengupta
