Ultra-small FePt/siRNA loaded mesoporous silica nanoplatform to deplete cysteine for enhanced ferroptosis in breast tumor therapy

A Tumor-Targeted Cascade Nanoreactor Based on Metal-Organic-Frameworks for Synergistic Ferroptosis−Starvation Anticancer Therapy

(2020) Xiuyan Wan et al.   ACS Nano

Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

(2019) Fan Zhang et al.   ACS Nano

Specifically Generation of Singlet Oxygen via Russell Mechanism in Hypoxic Tumor and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy

(2019) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

(2019) Michael D. Arensman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors

(2019) Qian Cheng et al.   NPG Asia Materials

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy

(2018) Ludan Yue et al.   Nanoscale

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

(2018) Zheyu Shen et al.   ACS Nano

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

(2018) Ziliang Dong et al.   NANO LETTERS

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

(2017) Qian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Thioredoxin System for Cancer Therapy

(2017) Junmin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Enhanced sequestration of selenite in water by nanoscale zero valent iron immobilization on carbon nanotubes by a combined batch, XPS and XAFS investigation

(2016) Guodong Sheng et al.   CARBON

Anion Assisted Synthesis of Large Pore Hollow Dendritic Mesoporous Organosilica Nanoparticles: Understanding the Composition Gradient

(2016) Yannan Yang et al.   CHEMISTRY OF MATERIALS

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death

(2015) Joungyoun Noh et al.   Nature Communications

RTCGAToolbox: A New Tool for Exporting TCGA Firehose Data

(2014) Mehmet Kemal Samur   PLoS One

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Selective Targeting of the Cysteine Proteome by Thioredoxin and Glutathione Redox Systems

(2013) Young-Mi Go et al.   MOLECULAR & CELLULAR PROTEOMICS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation

(2010) P. K. Mandal et al.   CANCER RESEARCH

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY