Article
Endocrinology & Metabolism
Xuyi Wang, Chang Chen, Cong Xie, Weikun Huang, Richard L. Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Zilin Sun, Tongzhi Wu
Summary: This study found that the serum bile acid response to a 75-g oral glucose load is attenuated in patients with 'early' type 2 diabetes, while in individuals without diabetes it correlates with 2-hour plasma glucose levels.
DIABETES OBESITY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Anubhav Pratap-Singh, Yigong Guo, Alberto Baldelli, Anika Singh
Summary: Injectable peptides like insulin and GLP-1 are commonly used for diabetes treatment, but injection administration has disadvantages. Buccal and sublingual routes are valid alternatives due to their accessibility, but there are challenges in peptide selection, drug encapsulation, and delivery system design. Using hydrophobic polymers and neutral or positively charged nanoparticles can improve drug efficiency and efficacy in buccal delivery. Unidirectional films and tablets show higher bioavailability compared to sprays, mitigating the impact of saliva and enzymatic digestion.
Article
Pharmacology & Pharmacy
Ruinan Wu, Zhanghan Wu, Liyun Xing, Xi Liu, Lei Wu, Zhou Zhou, Lian Li, Yuan Huang
Summary: GLP-1 RA are commonly used peptides for the treatment of type II diabetes, but their repetitive subcutaneous administration can reduce compliance and safety. A bio-inspired oral delivery system using 25HC-modified PLGA nanoparticles was designed to enhance the oral absorption of Lira, leading to improved therapeutic effects on diabetic mice. The system mimics natural cholesterol assimilation to achieve unidirectional transport across the intestinal epithelium, providing promising insights for oral delivery of GLP-1 RA.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Santosh Bashyal, Jo-Eun Seo, Young Wook Choi, Sangkil Lee
Summary: A novel nanocarrier platform utilizing hydrophobic ion-pairing greatly enhances intestinal absorption of oral peptide drugs. Evaluation showed that C1 outperforms C2 in oral efficacy and potential, with increased pharmacological availability. Studies suggest that HIP-nanocomplexes are effective for peptide delivery with improved intestinal absorption.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Integrative & Complementary Medicine
Li Qiang, Yang Qimeng, Han Jing, Liu Xiaohan, Fu Junjie, Yin Jian
Summary: Peptide dual agonists that target both GLP-1R and GCGR receptors have emerged as potential therapeutics for treating type 2 diabetes with obesity. O-GlcNAcylation was shown to improve the stability of a dual GLP-1R/GCGR agonist, leading to significant weight loss and hypoglycemic effects.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Review
Endocrinology & Metabolism
Yunbo Jia, Yang Liu, Linlin Feng, Siyu Sun, Guangwei Sun
Summary: This review summarizes the important roles of glucagon and its receptor in the development of diabetes, as well as recent research suggesting glucagon as a potential therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Isabella Jonsson, Kirstine N. Bojsen-Moller, Viggo B. Kristiansen, Simon Veedfald, Nicolai J. Wewer Albrechtsen, Trine R. Clausen, Rune E. Kuhre, Jens F. Rehfeld, Jens J. Holst, Sten Madsbad, Maria S. Svane
Summary: The study suggests that exogenous CDCA may enhance postprandial GLP-1 and glucagon secretion in individuals who have undergone RYGB, while the BA sequestrant colesevelam may decrease these hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xinyu Zhang, Xiao Duan, Yueying Hu, Zhongmin Tang, Congxiu Miao, Wei Tao, Jun Wu
Summary: The study developed a peptide-like polydrug for cancer chemotherapy using a simple one-step synthesis strategy, showing high drug loading and stability, and good therapeutic effects on tumors in vivo.
Article
Medicine, General & Internal
Weijie Chen, Shengnan Zhou, Jianchun Xiao, Wei Liu, Qiang Qu, Xiaodong He
Summary: The study demonstrated that Danning tablets intake effectively improved glucose and lipid metabolism in asymptomatic type 2 diabetes mellitus patients, along with an increase in the level of glucagon-like peptide-1.
Editorial Material
Endocrinology & Metabolism
Stella Papachristou, Djordje S. Popovic, Nikolaos Papanas
Summary: Tirzepatide is a dual GIP/GLP-1 receptor agonist with a long half-life, showing superiority in glycemic control and weight management in T2DM patients. While expected to enhance therapeutic options for T2DM, further data is needed for validation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Review
Endocrinology & Metabolism
Dominik Wollenhaupt, Jannik Wolters, Mirna Abd El Aziz, Michael A. Nauck
Summary: This study aimed to investigate the influence of various oral glucose-lowering medications (OGLM) on fasting plasma glucose (FPG) and hemoglobin A(1c) (HbA(1c)) levels after titration of basal insulin. A literature search retrieved 42 publications involving insulin-naive patients with type 2 diabetes. It was found that sulfonylureas, alone or in combination with metformin, hindered basal insulin titration, resulting in lower insulin doses and more hypoglycemic episodes, leading to poorer glycemic control. In contrast, adding a dipeptidyl peptidase-4 (DPP-4) inhibitor to metformin was more effective in achieving target FPG and HbA(1c) levels compared to metformin alone.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Pharmacology & Pharmacy
Songfeng Zhao, Zhiming Yan, Yue Du, Zeyun Li, Chunli Tang, Lin Jing, Lidan Sun, Qimeng Yang, Xueling Tang, Yongliang Yuan, Jing Han, Neng Jiang
Summary: This study demonstrates the therapeutic potential of dual agonists targeting GLP-1/glucagon and GLP-1/CCK2 receptors in the treatment of obesity and diabetes. The newly developed peptide, xGLP-1/GCG/gastrin, showed significant anti-diabetes and anti-obesity effects in both in vitro and in vivo experiments.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wei Liu, Ying Han, Xin Xin, Liqing Chen, Yanhong Liu, Chao Liu, Xintong Zhang, Mingji Jin, Jingzhe Jin, Zhonggao Gao, Wei Huang
Summary: In this study, a novel double layer nanoparticles were designed to enhance the oral bioavailability of anticancer drugs. The nanoparticles can act in a temporally controlled manner via an endogenous pathway in the intestine, overcoming multiple limitations of oral delivery. The results showed that the nanoparticles had good stability and prolonged intestinal retention time, as well as enhanced active transportation. Compared to conventional oral drugs, the use of these nanoparticles significantly improved the drug bioavailability and demonstrated better antitumor efficacy and safety.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ryosuke Ono, Kenichi Furihata, Yoshihiko Ichikawa, Yoshiomi Nakazuru, Arthur Bergman, Donal N. Gorman, Aditi R. Saxena
Summary: This study examined the safety, tolerability, pharmacokinetics and pharmacodynamics of danuglipron, a novel oral glucagon-like peptide-1 receptor agonist, in Japanese patients with type 2 diabetes mellitus. The results showed that danuglipron exhibited dose-proportional increases in plasma exposure and effectively reduced glycaemic parameters and body weight after 8 weeks of treatment, with a safety profile consistent with its mechanism of action.
DIABETES OBESITY & METABOLISM
(2023)
Review
Chemistry, Medicinal
Dihe Cheng, Shuo Yang, Xue Zhao, Guixia Wang
Summary: This article reviews the molecular mechanisms and potential effects of GLP-1 RA in neurodegenerative diseases, particularly diabetes-related Alzheimer's disease and Parkinson's disease.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Engineering, Chemical
Ashfaq Iftakher, Mohammed Sadaf Monjur, M. M. Faruque Hasan
Summary: Identifying sustainable chemical processes relies on selecting enabling materials that directly impact overall performance. Optimal material selection requires matching property targets and incorporating process knowledge. Making multi-scale decisions simultaneously is necessary to determine optimal process configurations, operating conditions, and material structures. Integrating molecular to process scale decisions within an equation-oriented optimization framework leads to large-scale mixed-integer nonlinear programs (MINLP). This article discusses the current state-of-the-art in computer-aided molecular and process design (CAMPD), highlighting key challenges and open questions for future research.
CHEMIE INGENIEUR TECHNIK
(2023)
Review
Energy & Fuels
Ali M. M. Hakami, Kazi N. N. Hasan, Mohammed Alzubaidi, Manoj Datta
Summary: In order to find the most accurate and efficient techniques for uncertainty modelling (UM) in power system stability analysis, this paper provides a comprehensive review and classification of the available UM techniques. The increasing uncertainties in power systems resulting from renewable energy sources, new loads, and deregulation of electricity markets make probabilistic power system analysis necessary. These factors significantly impact power system stability, requiring computationally intensive simulations including frequency, voltage, transient, and small disturbance stability. A total of 40 UM techniques are collated, providing their characteristics, advantages, disadvantages, and application areas, with a particular focus on accuracy and efficiency. The review recommends the most accurate and efficient UM techniques for probabilistic stability analysis in power systems with a high penetration of renewable energy.
Article
Chemistry, Physical
Khadiza Tul Kubra, Md. Munjur Hasan, Md. Nazmul Hasan, Md. Shad Salman, Md. Abdul Khaleque, Md. Chanmiya Sheikh, Ariyan Islam Rehan, Adiba Islam Rasee, R. M. Waliullah, Mrs Eti Awual, Mohammed Sohrab Hossain, Abdulmohsen K. D. Alsukaibi, Hamed M. Alshammari, Md. Rabiul Awual
Summary: The synthesis of the organic ligand EBMS and its immobilization onto mesoporous silica led to the successful fabrication of a composite adsorbent (FCA) for the separation, adsorption, and recovery of Tm(III) ions. The FCA displayed high kinetic performance and was unaffected by competing metal ions. The adsorption behavior of Tm(III) ions on FCA followed the Langmuir adsorption isotherm model with a maximum adsorption capacity of 168.57 mg/g. The FCA showed strong selectivity and potential for the effective separation and recovery of Tm(III) ions from waste samples.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Energy & Fuels
Pavitra Senthamilselvan Sengalani, Md Emdadul Haque, Manali S. Zantye, Akhilesh Gandhi, Mengdi Li, M. M. Faruque Hasan, Debangsu Bhattacharyya
Summary: This paper investigates the integration of a compressed-air energy storage (CAES) system with a natural gas combined-cycle (NGCC) power plant. The optimized integrated system has a higher net present value (NPV) than the NGCC-only system by optimizing variables such as storage capacity, storage pressure, and power plant load.
Review
Energy & Fuels
Sk. A. Shezan, Innocent Kamwa, Md. Fatin Ishraque, S. M. Muyeen, Kazi Nazmul Hasan, R. Saidur, Syed Muhammad Rizvi, Md Shafiullah, Fahad A. Al-Sulaiman
Summary: Energy consumption is growing rapidly, calling for the integration of renewable energy sources to meet the demand. Islanded hybrid microgrid systems (IHMS), combining multiple sustainable sources, offer an effective and environmentally friendly solution. However, due to the stochastic characteristics of renewable sources, there are technical challenges in integrating them into existing energy systems. This article provides an overview of research on the hybridization of renewable energy sources and discusses optimization approaches and control strategies for improving system stability, reliability, and cost-effectiveness.
Article
Chemistry, Multidisciplinary
Hae Hyun Hwang, Hyung Shik Kim, Dong Yun Lee
Summary: The conjugate of lactoferrin and heparin can attenuate angiogenic activity by binding to growth factors around the tumor tissue, and it can be orally absorbed and delivered to brain tumors through the blood-brain barrier. It inhibits angiogenesis in glioblastoma and shows potential as a new oral medication for treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Md. Mahbubul Haque Hasan, M. Mehedi Hasan Rocky, Md. Niamat Ullah, Muhammad A. R. Khan, Syeda Rahimon Naher, Shamim Akhtar
Summary: Densities, viscosities, and refractive indices were measured for binary systems of methanol with tetrahydrofuran and 1,4-dioxane over a range of compositions and temperatures. Properties such as excess molar volume, thermal expansivity, deviation in viscosity, free energy for the activation of viscous flow, and deviation in refractive index were derived. The effect of cross hydrogen bonding was found to be significant in both systems. The study also determined group-group interaction parameters for these cyclic ethers to extend the applicability of UNIFAC-VISCO model.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Md. Shad Salman, Md. Nazmul Hasan, Md. Munjur Hasan, Khadiza Tul Kubra, Md. Chanmiya Sheikh, Ariyan Islam Rehan, R. M. Waliullah, Adiba Islam Rasee, Mrs Eti Awual, Mohammed Sohrab Hossain, Abdulmohsen K. D. Alsukaibi, Hamed M. Alshammari, Md. Rabiul Awual
Summary: In this study, a functional organic ligand, 4-tert-Octyl-4-((phenyl)diazenyl)phenol (TPDP), was directly immobilized onto mesoporous silica to fabricate a composite adsorbent for the detection and removal of toxic copper (Cu(II)) ions from contaminated water. The composite adsorbent showed high sensitivity and selectivity towards Cu(II) ions, with a limit of detection of 0.28 μg/L. The adsorbent exhibited a high adsorption capacity, with a maximum adsorption capacity of 184.73 mg/g. The Cu(II) ions could be eluted and the adsorbent could be regenerated for reuse. This ligand-based composite adsorbent offers a low-cost and efficient method for the detection and removal of Cu(II) ions in real waste sample treatment.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Md Nazmul Hasan, Md Shad Salman, Md Munjur Hasan, Khadiza Tul Kubra, Md Chanmiya Sheikh, Ariyan Islam Rehan, Adiba Islam Rasee, Mrs Eti Awual, R. M. Waliullah, Mohammed Sohrab Hossain, Aminul Islam, Shahjalal Khandaker, Abdulmohsen K. D. Alsukaibi, Hamed M. Alshammari, Md Rabiul Awual
Summary: Organic ligand-based sustainable composite hybrid material (CMHs) was synthesized for the sensitive and selective adsorption of Lu(III) from waste samples. The adsorption of Lu(III) was influenced by solution pH, with slightly acidic conditions chosen for optimal separation and adsorption. Other metal ions did not interfere with Lu(III) adsorption due to the high affinity of Lu(III) to CMHs. The CMHs exhibited a high adsorption capacity and the adsorbed Lu(III) ions were easily eluted for regeneration.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Optics
Ang Deng, Trivikramarao Gavara, Muhammad Rosdi Abu Hassan, Daiqi Xiong, Md Imran Hasan, Wonkeun Chang
Summary: A fiber-based approach generates mid-infrared femtosecond pulses in the 3-4 mu$\umu$m spectral region with microjoule-level single pulse energy. This is achieved in a gas-filled antiresonant hollow-core fiber that is pumped by a two-micron light source. The technique provides a new pathway to build an all-fiber-based mid-infrared supercontinuum source, which promises to be a powerful tool for ultrahigh sensitivity molecular spectroscopy.
LASER & PHOTONICS REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Hyung Shik Kim, Sieun Lee, Dong Yun Lee
Summary: Aurozyme, a novel nanomedicine composed of gold nanoparticles and glycyrrhizin, shows promise as a therapeutic strategy for colitis. It converts harmful peroxidase-like activity to beneficial catalase-like activity, effectively scavenging reactive oxygen/reactive nitrogen species and damage-associated molecular patterns. It promotes anti-inflammatory effects, restores intestinal function, and increases beneficial probiotics, highlighting its potential for the treatment of inflammatory diseases.
Article
Multidisciplinary Sciences
Dongkyu Kang, Hyung Shik Kim, Soohyun Han, Yeonju Lee, Young-Pil Kim, Dong Yun Lee, Joonseok Lee
Summary: The authors designed a Nd-Yb co-doped nanomaterial as a near-infrared long-lifetime imaging-guided water-heating probe, demonstrating photothermal ablation in a glioblastoma pre-clinical model.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Hyung Shik Kim, Seok Chan Park, Hae Jin Kim, Dong Yun Lee
Summary: This study develops the Lf-GL conjugate to address the issues of GL's pharmacokinetics and delivery to tumor sites. It demonstrates that Lf-GL efficiently inhibits the action of HMGB1 in the tumor microenvironment, leading to the suppression of tumor angiogenesis and development. Moreover, Lf-GL improves the pharmacokinetic properties of GL and reduces tumor growth in a glioblastoma mouse model.
BIOMATERIALS RESEARCH
(2023)
Article
Chemistry, Physical
R. M. Waliullah, Ariyan Islam Rehan, Mrs Eti Awual, Adiba Islam Rasee, Md. Chanmiya Sheikh, Md. Shad Salman, Mohammed Sohrab Hossain, Md. Munjur Hasan, Khadiza Tul Kubra, Md. Nazmul Hasan, Hadi M. Marwani, Aminul Islam, Mohammed M. Rahman, Md. Abdul Khaleque, Md. Rabiul Awual
Summary: In this study, chitosan-treated nanocomposite was used as an effective adsorbent to remove methyl orange dye from contaminated water. The introduction of chitosan improved the adsorption capacity and rate effectively, and the nanocomposite adsorbent exhibited high reusability. Therefore, chitosan-based fibrous nanocomposite adsorbent is expected to become one of the best candidate materials for future industrial wastewater treatment.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Business
Chijioke Dike Uba, Md Nazmul Hasan, James Buba Mshelia
Summary: This paper examines how microbusiness owner-managers understand and approach social responsibility, finding that they primarily associate it with philanthropic activities. The study also explores the various practices that make up their overall Responsible Business Practices (RBPs). The findings have implications for existing literature, policymakers, and managers.
BUSINESS ETHICS THE ENVIRONMENT & RESPONSIBILITY
(2023)