Journal
MOLECULES
Volume 26, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules26123590
Keywords
Herba Epimedii; Epimedium koreanum; prenylated flavonoid; PCSK9; LDLR; cholesterol
Funding
- National Research Foundation of Korea (NRF) in the Korean government (MSIT) [NRF-2019R1A2C2009053]
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Phytochemical investigation of Epimedium koreanum led to the discovery of new acylated flavonoid glycosides with inhibitory effects on PCSK9 mRNA expression. Compound 7, in particular, was found to increase LDLR mRNA expression, potentially leading to increased LDL uptake and reduced cholesterol levels.
Phytochemical investigation on the n-BuOH-soluble fraction of the aerial parts of Epimedium koreanum using the PCSK9 mRNA monitoring assay led to the identification of four previously undescribed acylated flavonoid glycosides and 18 known compounds. The structures of new compounds were elucidated by NMR, MS, and other chemical methods. All isolated compounds were tested for their inhibitory activity against PCSK9 mRNA expression in HepG2 cells. Of the isolates, compounds 6, 7, 10, 15, and 17-22 were found to significantly inhibit PCSK9 mRNA expression. In particular, compound 7 was shown to increase LDLR mRNA expression. Thus, compound 7 may potentially increase LDL uptake and lower cholesterol levels in the blood.
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