Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders
Authors
Keywords
-
Journal
MOLECULAR PSYCHIATRY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-06-14
DOI
10.1038/s41380-021-01175-1
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice
- (2020) Nabila Haji et al. Molecular Autism
- Cognitive impairment in children with CACNA 1A mutations
- (2019) Veronique Humbertclaude et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
- (2019) Vikaas S. Sohal et al. MOLECULAR PSYCHIATRY
- Both gain‐of‐function and loss‐of‐function de novo CACNA 1A mutations cause severe developmental epileptic encephalopathies in the spectrum of Lennox‐Gastaut syndrome
- (2019) Xiao Jiang et al. EPILEPSIA
- Remodeled cortical inhibition prevents motor seizures in generalized epilepsy
- (2018) Xiao Jiang et al. ANNALS OF NEUROLOGY
- The neuropsychiatric phenotype in CACNA1A mutations: a retrospective single center study and review of the literature
- (2018) E. Indelicato et al. EUROPEAN JOURNAL OF NEUROLOGY
- The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice
- (2018) Daniel F. Manvich et al. Scientific Reports
- De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies
- (2016) Candace T. Myers et al. AMERICAN JOURNAL OF HUMAN GENETICS
- BiallelicCACNA1Amutations cause early onset epileptic encephalopathy with progressive cerebral, cerebellar, and optic nerve atrophy
- (2016) Karit Reinson et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Prefrontal Parvalbumin Neurons in Control of Attention
- (2016) Hoseok Kim et al. CELL
- Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures
- (2016) Kathrin Töllner et al. EPILEPSY & BEHAVIOR
- Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy
- (2016) V. C. Bomben et al. JOURNAL OF NEUROSCIENCE
- Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons
- (2016) S Canetta et al. MOLECULAR PSYCHIATRY
- Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory
- (2016) Dohoung Kim et al. NEURON
- DREADDs for Neuroscientists
- (2016) Bryan L. Roth NEURON
- Interneurons Are Necessary for Coordinated Activity During Reversal Learning in Orbitofrontal Cortex
- (2015) Gregory B. Bissonette et al. BIOLOGICAL PSYCHIATRY
- CACNA1A haploinsufficiency causes cognitive impairment, autism and epileptic encephalopathy with mild cerebellar symptoms
- (2015) Lena Damaj et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study
- (2015) Heike Jacobi et al. LANCET NEUROLOGY
- Gamma Rhythms Link Prefrontal Interneuron Dysfunction with Cognitive Inflexibility in Dlx5/6+/− Mice
- (2015) Kathleen K.A. Cho et al. NEURON
- Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility
- (2015) Andrew J. Murray et al. Scientific Reports
- The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
- (2015) Jillian M. Heisler et al. Jove-Journal of Visualized Experiments
- Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli
- (2014) Joshua H Siegle et al. NATURE NEUROSCIENCE
- Orbitofrontal Cortex Is Required for Optimal Waiting Based on Decision Confidence
- (2014) Armin Lak et al. NEURON
- Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons
- (2013) Gregory B. Bissonette et al. BEHAVIOURAL BRAIN RESEARCH
- Postnatal Loss of P/Q-Type Channels Confined to Rhombic-Lip-Derived Neurons Alters Synaptic Transmission at the Parallel Fiber to Purkinje Cell Synapse and Replicates Genomic Cacna1a Mutation Phenotype of Ataxia and Seizures in Mice
- (2013) T. Maejima et al. JOURNAL OF NEUROSCIENCE
- Cortical interneurons that specialize in disinhibitory control
- (2013) Hyun-Jae Pi et al. NATURE
- Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes
- (2013) Isabel del Pino et al. NEURON
- Ablation of CaV2.1 Voltage-Gated Ca2+ Channels in Mouse Forebrain Generates Multiple Cognitive Impairments
- (2013) Robert Theodor Mallmann et al. PLoS One
- Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission
- (2012) Sung Han et al. NATURE
- Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS
- (2012) Sanjeev Rajakulendran et al. Nature Reviews Neurology
- Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome
- (2012) C. S. Cheah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits
- (2012) Jyoti C. Patel et al. Nature Communications
- Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors
- (2011) Dionisio A. Amodeo et al. BEHAVIOURAL BRAIN RESEARCH
- Purkinje Cell-Specific Ablation of CaV2.1 Channels is Sufficient to Cause Cerebellar Ataxia in Mice
- (2011) Boyan Todorov et al. CEREBELLUM
- Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations
- (2011) M. D. Mark et al. JOURNAL OF NEUROSCIENCE
- A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
- (2011) M Carlén et al. MOLECULAR PSYCHIATRY
- Neocortical excitation/inhibition balance in information processing and social dysfunction
- (2011) Ofer Yizhar et al. NATURE
- Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy
- (2011) Ke-Xin Li et al. NATURE NEUROSCIENCE
- Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons
- (2011) Guo-He Tan et al. NATURE NEUROSCIENCE
- Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
- (2011) E. Rossignol NEURAL PLASTICITY
- Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling
- (2010) Pietro Fazzari et al. NATURE
- Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
- (2010) Hsiao-Tuan Chao et al. NATURE
- NMDA Receptor Ablation on Parvalbumin-Positive Interneurons Impairs Hippocampal Synchrony, Spatial Representations, and Working Memory
- (2010) Tatiana Korotkova et al. NEURON
- ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation
- (2010) Y.-J. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Age-related spatial and nonspatial short-term memory in Cav2.1α1 mutant mice, Rolling Nagoya
- (2009) Eiki Takahashi et al. BEHAVIOURAL BRAIN RESEARCH
- Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice
- (2009) Eiki Takahashi et al. BRAIN RESEARCH
- Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages
- (2009) Vitor H. Sousa et al. CEREBRAL CORTEX
- Array-CGH detection of a de novo 0.7-Mb deletion in 19p13.13 includingCACNA1Aassociated with mental retardation and epilepsy with infantile spasms
- (2009) Stéphane Auvin et al. EPILEPSIA
- Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
- (2009) Vikaas S. Sohal et al. NATURE
- Driving fast-spiking cells induces gamma rhythm and controls sensory responses
- (2009) Jessica A. Cardin et al. NATURE
- Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
- (2009) L. Wen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Double Dissociation of the Effects of Medial and Orbital Prefrontal Cortical Lesions on Attentional and Affective Shifts in Mice
- (2008) G. B. Bissonette et al. JOURNAL OF NEUROSCIENCE
- Calcium Channel Regulation and Presynaptic Plasticity
- (2008) William A. Catterall et al. NEURON
- High-Resolution Labeling and Functional Manipulation of Specific Neuron Types in Mouse Brain by Cre-Activated Viral Gene Expression
- (2008) Sandra J. Kuhlman et al. PLoS One
- Motor and cognitive deficits in the heterozygous leaner mouse, a Cav2.1 voltage-gated Ca2+ channel mutant
- (2007) Isabel Alonso et al. NEUROBIOLOGY OF AGING
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started