Mechanistic Model for the Prediction of Small-Molecule Vitreal Clearance Combining Diffusion-Limited and Permeability-Limited Clearance

Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues

(2021) Anam Hammid et al.   MOLECULAR PHARMACEUTICS

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery

(2020) Laura Hellinen et al.   Pharmaceutics

Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

(2019) Astrid Subrizi et al.   DRUG DISCOVERY TODAY

Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics

(2019) L. Brockhaus et al.   CLINICAL MICROBIOLOGY AND INFECTION

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

(2019) Eva Ramsay et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Expression, activity and pharmacokinetic impact of ocular transporters

(2018) Kati-Sisko Vellonen et al.   ADVANCED DRUG DELIVERY REVIEWS

Improving the Interpretation of Small Molecule Diffusion Coefficients

(2018) Robert Evans et al.   ANALYTICAL CHEMISTRY

Esterase activity in porcine and albino rabbit ocular tissues

(2018) Emma M. Heikkinen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Diffusion through the ex vivo vitreal body – Bovine, porcine, and ovine models are poor surrogates for the human vitreous

(2018) Sara Shafaie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

pH-dependent solubility and permeability profiles: A useful tool for prediction of oral bioavailability

(2017) P. Sieger et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model

(2017) Laurence A. Hutton-Smith et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetic aspects of retinal drug delivery

(2017) Eva M. del Amo et al.   PROGRESS IN RETINAL AND EYE RESEARCH

A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration

(2016) Laurence A. Hutton-Smith et al.   MOLECULAR PHARMACEUTICS

Estimation of Intra-vitreal Half-Lifes in the Rabbit Eye with Semi-mechanistic Equations

(2016) Walter Schmitt   PHARMACEUTICAL RESEARCH

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

(2015) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

(2015) Eva M. del Amo et al.   EXPERIMENTAL EYE RESEARCH

Simulating Intravitreal Injections in Anatomically Accurate Models for Rabbit, Monkey, and Human Eyes

(2012) Paul J. Missel   PHARMACEUTICAL RESEARCH

Prediction of the Vitreal Half-Life of Small Molecular Drug-Like Compounds

(2012) Heidi Kidron et al.   PHARMACEUTICAL RESEARCH

Diffusion characteristics of vitreous humour and saline solution follow the Stokes Einstein equation

(2009) Svanborg Gisladottir et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Prediction of Vitreal Half-Life Based on Drug Physicochemical Properties: Quantitative Structure–Pharmacokinetic Relationships (QSPKR)

(2008) Chandrasekar Durairaj et al.   PHARMACEUTICAL RESEARCH