Ocular Pharmacokinetics of Intravitreally Injected Protein Therapeutics: Comparison among Standard-of-Care Formats
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Ocular Pharmacokinetics of Intravitreally Injected Protein Therapeutics: Comparison among Standard-of-Care Formats
Authors
Keywords
-
Journal
MOLECULAR PHARMACEUTICS
Volume 18, Issue 6, Pages 2208-2217
Publisher
American Chemical Society (ACS)
Online
2021-05-20
DOI
10.1021/acs.molpharmaceut.0c01218
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin
- (2020) Simon Hauri et al. Pharmaceutics
- Use of Ella® to facilitate drug quantification and antidrug antibody detection in preclinical studies
- (2019) Uwe Wessels et al. Bioanalysis
- Simultaneous Inhibition of Angiopoietin-2 and VEGF-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial
- (2019) Jayashree Sahni et al. OPHTHALMOLOGY
- Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration.
- (2019) David S. Liao et al. OPHTHALMOLOGY
- Brolucizumab: First Approval
- (2019) Anthony Markham DRUGS
- Stabilization of α-synuclein oligomers using formaldehyde
- (2019) Harm Ruesink et al. PLoS One
- Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules
- (2019) Susan R. Crowell et al. Translational Vision Science & Technology
- Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction
- (2019) Antonello Caruso et al. MOLECULAR PHARMACEUTICS
- Correspondence
- (2019) Antonello Caruso et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model
- (2018) Laurence A. Hutton-Smith et al. MOLECULAR PHARMACEUTICS
- Spectroscopic studies on the gemini surfactant mediated refolding of human serum albumin
- (2017) Nuzhat Gull et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Binding to Ocular Albumin as a Half-Life Extension Principle for Intravitreally Injected Drugs: Evidence from Mechanistic Rat and Rabbit Studies
- (2017) Holger Fuchs et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model
- (2017) Laurence A. Hutton-Smith et al. MOLECULAR PHARMACEUTICS
- Pharmacokinetic aspects of retinal drug delivery
- (2017) Eva M. del Amo et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics
- (2017) Christina L.Zuch de Zafra et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Long-acting protein drugs for the treatment of ocular diseases
- (2017) Joy G. Ghosh et al. Nature Communications
- Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
- (2016) Jörg T Regula et al. EMBO Molecular Medicine
- A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration
- (2016) Laurence A. Hutton-Smith et al. MOLECULAR PHARMACEUTICS
- Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab
- (2016) Whitney Shatz et al. MOLECULAR PHARMACEUTICS
- Single-Chain Antibody Fragment VEGF Inhibitor RTH258 for Neovascular Age-Related Macular Degeneration
- (2016) Frank G. Holz et al. OPHTHALMOLOGY
- Drug discovery in ophthalmology: past success, present challenges, and future opportunities
- (2016) Nicholas J. D. Gower et al. BMC Ophthalmology
- Diffusion Regulation in the Vitreous Humor
- (2015) Benjamin Tillmann Käsdorf et al. BIOPHYSICAL JOURNAL
- Does Topology Drive Fiber Polymerization?
- (2014) Lihong Huang et al. BIOCHEMISTRY
- Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)
- (2014) Ursula Schmidt-Erfurth et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo
- (2013) Qingguo Xu et al. JOURNAL OF CONTROLLED RELEASE
- Aflibercept in wet AMD: specific role and optimal use
- (2013) Francesco Semeraro et al. Drug Design Development and Therapy
- Anti-VEGF Treatment Strategies for Wet AMD
- (2012) Jaclyn L. Kovach et al. Journal of Ophthalmology
- Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab
- (2011) C H Meyer et al. EYE
- Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
- (2011) W. Schaefer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Average protein density is a molecular-weight-dependent function
- (2004) Hannes Fischer et al. PROTEIN SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started