A hybrid mechanistic-empirical model for in silico mammalian cell bioprocess simulation

Constrained global sensitivity analysis for bioprocess design space identification

(2019) Pavlos Kotidis et al.   COMPUTERS & CHEMICAL ENGINEERING

Predicting industrial scale cell culture seed trains ‐ a Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using a MCMC method

(2019) Tanja Hernández Rodríguez et al.   BIOTECHNOLOGY AND BIOENGINEERING

A predictive mathematical model of cell cycle, metabolism and apoptosis of monoclonal antibody‐ producing GS‐NS0 cells

(2019) António L. Grilo et al.   Biotechnology Journal

Metabolic engineering of Chinese hamster ovary cells towards reduced biosynthesis and accumulation of novel growth inhibitors in fed-batch cultures

(2019) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations

(2019) Ryan J. Graham et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioprocessing in the Digital Age: The Role of Process Models

(2019) Harini Narayanan et al.   Biotechnology Journal

The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer

(2019) Yang et al.   Cells

Kinetic model optimization and its application to mitigating the Warburg effect through multiple enzyme alterations

(2019) Conor O'Brien et al.   METABOLIC ENGINEERING

Probing lactate metabolism variations in large-scale bioreactors

(2018) Sen Xu et al.   BIOTECHNOLOGY PROGRESS

Challenges and opportunities in biopharmaceutical manufacturing control

(2018) Moo Sun Hong et al.   COMPUTERS & CHEMICAL ENGINEERING

Model-Based Dynamic Optimization of Monoclonal Antibodies Production in Semibatch Operation—Use of Reformulation Techniques

(2018) Chrysoula D. Kappatou et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Model-Based Identification of Cell-Cycle Dependent Metabolism and Putative Autocrine Effects in Antibody Producing CHO Cell Culture

(2018) Johannes Möller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar

(2017) Seokkyun Kim et al.   mAbs

Workflow for Target-Oriented Parametrization of an Enhanced Mechanistic Cell Culture Model

(2017) Sophia Ulonska et al.   Biotechnology Journal

Regulation of Glucose Metabolism – A Perspective From Cell Bioprocessing

(2016) Bhanu Chandra Mulukutla et al.   TRENDS IN BIOTECHNOLOGY

Mechanism for multiplicity of steady states with distinct cell concentration in continuous culture of mammalian cells

(2015) Andrew Yongky et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells

(2015) Bhanu Chandra Mulukutla et al.   PLoS One

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Drift, Evolution, and Divergence in Biologics and Biosimilars Manufacturing

(2014) Sundar Ramanan et al.   BIODRUGS

A model reduction method for biochemical reaction networks

(2014) Shodhan Rao et al.   BMC Systems Biology

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

(2013) Laura Novellasdemunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macroscopic modelling of overflow metabolism and model based optimization of hybridoma cell fed-batch cultures

(2012) Zakaria Amribt et al.   BIOCHEMICAL ENGINEERING JOURNAL

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mining manufacturing data for discovery of high productivity process characteristics

(2010) Salim Charaniya et al.   JOURNAL OF BIOTECHNOLOGY

Pfkfb3is transcriptionally upregulated in diabetic mouse liver through proliferative signals

(2009) Joan Duran et al.   FEBS Journal