Review
Medicine, Research & Experimental
Ziyao Qin, Mei Zheng
Summary: Melanoma, the most aggressive and deadly type of skin cancer, has a poor prognosis with metastasis. Recently, new and effective therapies, including targeted agents and immunotherapy, have emerged for metastatic melanoma. This article reviews recent clinical trials of targeted therapy and immunotherapy for metastatic melanoma, with a focus on improving treatment efficacy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Evan D. Bander, Melissa Yuan, Joseph A. Carnevale, Anne S. Reiner, Katherine S. Panageas, Michael A. Postow, Viviane Tabar, Nelson S. Moss
Summary: Breakthroughs in targeted and immunotherapies have significantly improved the prognosis and overall survival of patients with melanoma brain metastasis in recent years. Factors such as serum lactate dehydrogenase levels and the presence of extracranial disease are associated with worse prognosis.
Article
Immunology
Chun Pan, Jingzhe Shang, Haiqin Jiang, Ying Shi, Wenyue Zhang, Jingshu Xiong, Youming Mei, Siyu Long, Gai Ge, Zhenzhen Wang, Ziwei Wu, Hongsheng Wang, Aiping Wu
Summary: This study found that halo nevi and stable vitiligo have similar molecular immunological features, but halo nevi exhibit stronger immune activity. The research also revealed the high expression levels of immune cells in halo nevi.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Filip Tichanek, Asta Foersti, Akseli Hemminki, Otto Hemminki, Kari Hemminki
Summary: This study analysed the survival rates of melanoma in Denmark, Finland, Norway, and Sweden from 1971 to 2020. The results showed a significant increase in survival rates over the past few decades, which could be attributed to the population's awareness of sun protection and early detection, as well as the use of novel targeted therapies and immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2023)
Editorial Material
Oncology
Meghan J. J. Mooradian, Ryan J. J. Sullivan
Summary: The development of effective BRAF-targeted therapy and immune checkpoint inhibition has revolutionized the treatment of advanced metastatic melanoma. However, it remains unclear which treatment option is the best for patients with resected, BRAF-mutant stage III melanoma. This article presents arguments for and against the use of BRAF-targeted therapy and immunotherapy in these patients.
Review
Oncology
Claudia Trojaniello, Francesca Sparano, Eleonora Cioli, Paolo Antonio Ascierto
Summary: This review discusses the efficacy and safety of sequential immunotherapy with targeted therapy in patients with BRAF-mutated melanoma. The findings suggest that targeted therapy provides rapid disease control, but the development of secondary resistance limits the duration of responses; in contrast, immunotherapy may induce slow but more durable responses. Therefore, a combination strategy for the use of these therapies seems promising.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Oncology
Claudia Trojaniello, Jason J. Luke, Paolo A. Ascierto
Summary: Melanoma, the most fatal skin cancer, has seen a significant revolution in treatment since 2011 with targeted therapy and immunotherapy. Current research focuses on preventing resistance, increasing drug effectiveness, and exploring new treatment combinations and targets to benefit more patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Marie-Luise Hilbers, Florentia Dimitriou, Peter Lau, Prachi Bhave, Grant A. McArthur, Lisa Zimmer, Ken Kudura, Camille L. Gerard, Mitchell P. Levesque, Olivier Michielin, Reinhard Dummer, Phil F. Cheng, Joanna Mangana
Summary: The study showed that the combination of immune check-point inhibitors/targeted therapy as the first-line treatment for melanoma brain metastases has certain efficacy, with immunotherapy showing better results in terms of overall survival and outperforming targeted therapy in BRAFV600 patients.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Marie-Alix Mangin, Amelie Boespflug, Delphine Maucort Boulch, Charles-Herve Vacheron, Isabelle Carpentier, Luc Thomas, Stephane Dalle
Summary: In patients with metastatic melanoma, prior treatment with ICI followed by CC may lead to better clinical outcomes compared to prior treatment with MAPKi followed by CC. Further investigation is needed to confirm the potential benefits of CC in this setting.
Article
Pathology
Sydney L. Proffer, Ruifeng Guo, Addison M. Demer, Margot S. Peters
Summary: The potential significance of tissue eosinophils in melanomas and their association with the prognosis of patients with metastatic melanoma were investigated. In a retrospective study, it was found that the presence of tissue eosinophils in melanomas or nevi was associated with a favorable response to checkpoint inhibitor therapy in patients with metastatic melanoma.
Review
Health Care Sciences & Services
Roxana Nedelcu, Alexandra Dobre, Alice Brinzea, Ionela Hulea, Razvan Andrei, Sabina Zurac, Mihaela Balaban, Mihaela Antohe, Lorena Manea, Andreea Calinescu, Anastasia Coman, Florentina Pantelimon, Adina Dobritoiu, Catalin Popescu, Raluca Popescu, Elena Balasescu, Daniela Ion, Gabriela Turcu
Summary: Halo nevi, a type of immunological leukoderma, have unclear etiology and pathogenesis. Studying Sutton nevi can provide valuable insights into the human body's anti-tumor reactions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Lorenza Burzi, Aurora Maria Alessandrini, Pietro Quaglino, Bianca Maria Piraccini, Emi Dika, Simone Ribero
Summary: Immunotherapy with checkpoint inhibitors has shown significant improvement in the outcome for stage III and IV melanoma patients, but cutaneous adverse events are commonly reported during treatment. These adverse events include pigmentation changes such as vitiligo, the Sutton phenomenon, melanosis, and toxicities affecting hair and nails.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Noa Sabag, Alexander Yakobson, Meir Retchkiman, Eldad Silberstein
Summary: This review provides a brief overview of malignant melanoma and its treatment, focusing on surgery in early stages and the paradigm shift to immunotherapy and targeted therapies in advanced stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Saira Sanjida, Brigid Betz-Stablein, Victoria Atkinson, Monika Janda, Ramez Barsoum, Harrison Aljian Edwards, Frank Chiu, My Co Tran, H. Peter Soyer, Helmut Schaider
Summary: This study describes the characteristics and outcomes of patients with advanced melanoma receiving immunotherapies and/or targeted therapies in a real-world setting. Despite having multiple comorbidities, the survival of these patients was similar or better compared to those in clinical trials.
Article
Oncology
Fernanda Costa Svedman, Ishani Das, Rainer Tuominen, Eva Darai Ramqvist, Veronica Hoiom, Suzanne Egyhazi Brage
Summary: The introduction of targeted therapies and immunotherapies has greatly improved the clinical outcomes for patients with advanced cutaneous melanoma. However, only a subset of patients benefit from these treatments in the long term. This study aims to identify gene signatures that can predict the treatment outcomes in melanoma patients. The findings suggest that up-regulation of immune-related genes is associated with better outcomes in targeted therapy, while down-regulation of proliferation and up-regulation of allograft rejection genes favor patients treated with immune checkpoint inhibitors.
Letter
Dermatology
Paola Corneli, Nicola di Meo, Serena Fagotti, Claudio Conforti, Eleonora Farinazzo, Alberto Zacchi, Chiara Retrosi, Roberta Vezzoni, Maria A. Pizzichetta, Iris Zalaudek
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2020)
Article
Dermatology
C. Conforti, M. A. Pizzichetta, S. Vichi, F. Toffolutti, D. Serraino, N. Di Meo, R. Giuffrida, T. Deinlein, J. Giacomel, C. Rosendahl, J. Y. Gourhant, I Zalaudek
Summary: This retrospective study evaluated the clinical and dermoscopic features of sclerodermiform basal cell carcinoma (BCC) in different body localizations, showing that nodular BCCs are more commonly found in the body macro-area while sclerodermiform BCCs tend to occur in the head/neck district, each with specific dermoscopic characteristics that can aid in clinical diagnosis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
S. Borsari, F. Peccerillo, R. Pampena, M. Lai, M. Spadafora, E. Moscarella, A. Lallas, M. A. Pizzichetta, I Zalaudek, L. Del Regno, K. Peris, G. Pellacani, C. Longo
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Dermatology
Claudio Conforti, Roberta Giuffrida, Iris Zalaudek, Fabrizio Guarneri, Serafinella Patrizia Cannavo, Maria Antonietta Pizzichetta, Serena Bonin, Paola Corneli, Rossana Bussani, Giulia Bazzacco, Nicola Di Meo
Summary: Surgery is the primary treatment for basal cell carcinoma (BCC), but incomplete excisions are possible. This study assessed the accuracy of dermoscopy and clinical evaluation in detecting BCC borders and found that dermoscopy can improve identification of surgical margins for BCC excision, especially through observation of nonclassical dermoscopic criteria.
DERMATOLOGIC SURGERY
(2021)
Letter
Dermatology
S. Fagotti, M. A. Pizzichetta, P. Corneli, F. Toffolutti, D. Serraino, N. di Meo, I. Zalaudek
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Oncology
Antonella Vecchiato, Simone Mocellin, Paolo Del Fiore, Giulio Tosti, Paolo A. Ascierto, Maria Teresa Corradin, Vincenzo De Giorgi, Giuseppe Giudice, Paola Queirolo, Caterina Ferreli, Marcella Occelli, Monica Giordano, Giusto Trevisan, Luigi Mascheroni, Alessandro Testori, Romina Spina, Alessandra Buja, Francesco Cavallin, Corrado Caraco, Antonio Sommariva, Carlo Riccardo Rossi, Italian Melanoma Intergrp IMI
Summary: This study analyzed the quality indicators of postoperative complications in non-metastatic skin melanoma surgical treatment in Italy, finding rates of wound infection, dehiscence, and seroma within certain ranges. These findings contribute to setting recommended standards for melanoma centers, aiming to improve the quality of surgery offered to patients.
Article
Dermatology
Maria Antonietta Pizzichetta, Vincenzo Canzonieri, Pietro Rubegni, Paola Corneli, Fabio Puglisi, Iris Zalaudek, Elisa Cinotti
Summary: Amelanotic/hypomelanotic melanoma (AHM) poses a challenge in clinical diagnosis. Dermoscopy helps improve AHM diagnosis by visualizing little pigment and vascular pattern. Reflectance confocal microscopy (RCM) further enhances diagnostic accuracy of AHM, with major criteria including nonedged papillae and/or cytological atypia, and minor criteria like roundish pagetoid cells.
JOURNAL OF DERMATOLOGY
(2021)
Review
Oncology
Mattia Garutti, Serena Bonin, Silvia Buriolla, Elisa Bertoli, Maria Antonietta Pizzichetta, Iris Zalaudek, Fabio Puglisi
Summary: Immunotherapy has revolutionized the treatment of melanoma, but the lack of clinically validated predictive biomarkers contributes to its unpredictable efficacy. Predictive biomarkers could aid in patient stratification, drug selection, and treatment adjustment, yet their difficulty in obtaining reflects the complexity of tumor biology. Biomarkers play a crucial role in guiding clinicians through the decision-making process for checkpoint inhibition in melanoma.
Article
Dermatology
Eleonora Di Matteo, Riccardo Pampena, Maria A. Pizzichetta, Elisa Cinotti, Johanna Chester, Shaniko Kaleci, Marco Manfredini, Stefania Guida, Emi Dika, Elvira Moscarella, Aimilios Lallas, Zoe Apalla, Giuseppe Argenziano, Jian L. Perrot, Linda Tognetti, Michela Lai, Carmen Cantisani, Vincenzo Roberti, Diletta Fiorani, Carlotta Baraldi, Leonardo Veneziano, Chryssoula Papageorgiou, Silvana Ciardo, Pietro Rubegni, Iris Zalaudek, Annalisa Patrizi, Caterina Longo, Luca Bianchi, Giovanni Pellacani, Francesca Farnetani
Summary: This study aims to identify dermoscopic features for differential diagnosis between atypical basal cell carcinoma and melanoma, and to assess the clinical impact of these findings. The results suggest that atypical vascular pattern can be considered a shared feature of both types of skin cancer, and the proposed score improves diagnostic accuracy and confidence.
EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Dermatology
S. Caini, M. Brusasco, G. Niero, V. De Giorgi, M. Lombardo, C. Massone, M. Medri, G. Palmieri, M. A. Pizzichetta, P. Quaglino, R. Satta, C. Feliciani, S. Gandini, I. Stanganelli
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Maria A. Pizzichetta, Jerry Polesel, Jean L. Perrot, Pietro Rubegni, Diletta Fiorani, Arianna Rizzo, Ignazio Stanganelli, Serena Magi, Laura Mazzoni, Matelda Medri, Michele M. Dominici, Federica Toffolutti, Francesca Farnetani, Nicola Lippolis, Gioia Pedroni, Silvana Ciardo, Alessandra G. Condorelli, Claudio Conforti, Giovanni Pellacani, Iris Zalaudek, Fabio Puglisi, Elisa Cinotti
Summary: This study aimed to quantify the predictive value of dermoscopic and reflectance confocal microscopy (RCM) features for AHLM/LMM. The results showed that certain specific features were significantly independent diagnostic factors for early diagnosis of AHLM/LMM.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Linda Tognetti, Alessandra Cartocci, Magdalena Zychowska, Imma Savarese, Elisa Cinotti, Maria Antonietta Pizzichetta, Elvira Moscarella, Caterina Longo, Francesca Farnetani, Stefania Guida, John Paoli, Aimilios Lallas, Danica Tiodorovic, Ignazio Stanganelli, Serena Magi, Emi Dika, Iris Zalaudek, Mariano Suppa, Giuseppe Argenziano, Giovanni Pellacani, Jean Luc Perrot, Chiara Miracapillo, Giovanni Rubegni, Gabriele Cevenini, Pietro Rubegni
Summary: Due to the progressive ageing of the population, the incidence of facial lentigo maligna (LM) is increasing. This study aims to develop a risk-scoring classifier-based algorithm to estimate the probability of atypical pigmented facial lesions (aPFLs) being malignant, and compare its diagnostic accuracy with that of dermatologists. The results show that the facial iDScore model is more accurate in diagnosis and can reduce the number of unnecessary biopsies.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Maria A. Pizzichetta, Vincenzo Canzonieri, Loredana Militello, Borsatt Eugenio, Giovanni Lo Re, Silvia Bolzonello, Matteo Olivieri, Caterina Pinzani, Giovanni Magaton-Rizzi, Fabio Puglisi, Iris Zalaudek
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Andrea Anichini, Salvatore Asero, Melissa Bersanelli, Corrado Caraco, Vincenzo De Giorgi, Anna Maria Di Giacomo, Claudio Feliciani, Virginia Ferraresi, Paola Ghiorzo, Antonio M. Grimaldi, Michele Guida, Mario Mandala, Daniela Massi, Simone Mocellin, Giuseppe Palmieri, Roberto Patuzzo, Maria Antonietta Pizzichetta, Roberto Ricci, Giulio Rossi, Pietro Quaglino, Paola Queirolo, Rebecca Senetta, Ignazio Stanganelli, Marco Tucci
Summary: The COVID-19 pandemic has affected skin melanoma management in Italy, leading to a decrease in new diagnoses, biopsies, surgeries, and pathology reports, but severe cases are being promptly managed. The experience has highlighted the importance of utilizing telemedicine to support healthcare services.
DERMATOLOGY REPORTS
(2021)