Lack of ∆5 Desaturase Activity Impairs EPA and DHA Synthesis in Fish Cells from Red Sea Bream and Japanese Flounder

Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study

(2020) Chengjie Liu et al.   MARINE BIOTECHNOLOGY

A key metabolic gene for recurrent freshwater colonization and radiation in fishes

(2019) Asano Ishikawa et al.   SCIENCE

Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level

(2019) Diego Garrido et al.   Scientific Reports

CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes

(2019) Alex K. Datsomor et al.   Scientific Reports

Methyl-end desaturases with ∆12 and ω3 regioselectivities enable the de novo PUFA biosynthesis in the cephalopod Octopus vulgaris

(2019) Diego Garrido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals

(2018) Naoki Kabeya et al.   Science Advances

Capacity for eicosapentaenoic acid and arachidonic acid biosynthesis in silver barb (Barbonymus gonionotus): Functional characterisation of a Δ6/Δ8/Δ5 Fads2 desaturase and Elovl5 elongase

(2018) M. Janaranjani et al.   AQUACULTURE

Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates

(2018) Mónica Lopes-Marques et al.   BMC EVOLUTIONARY BIOLOGY

A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum

(2018) Renato B. Ferraz et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

“Out of the Can”: A Draft Genome Assembly, Liver Transcriptome, and Nutrigenomics of the European Sardine, Sardina pilchardus

(2018) André Machado et al.   Genes

Identification of Quantitative Trait Loci for Resistance to RSIVD in Red Sea Bream (Pagrus major)

(2017) Eitaro Sawayama et al.   MARINE BIOTECHNOLOGY

The FAD2 Gene in Plants: Occurrence, Regulation, and Role

(2017) Aejaz A. Dar et al.   Frontiers in Plant Science

Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish

(2017) Angela Oboh et al.   Scientific Reports

A fatty acyl desaturase ( fads2 ) with dual Δ6 and Δ5 activities from the freshwater carnivorous striped snakehead Channa striata

(2016) Meng-Kiat Kuah et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

(2016) L. Filipe C. Castro et al.   PROGRESS IN LIPID RESEARCH

The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

(2015) Hui Gyu Park et al.   FASEB JOURNAL

Very long chain omega-3 (n-3) fatty acids and human health

(2014) Philip C. Calder   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Diversification of substrate specificities in teleostei Fads2: characterization of Δ4 and Δ6Δ5 desaturases ofChirostoma estor

(2014) Jorge Fonseca-Madrigal et al.   JOURNAL OF LIPID RESEARCH

Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life

(2012) Danielle Swanson et al.   Advances in Nutrition

LC-PUFA from photosynthetic microalgae: occurrence, biosynthesis, and prospects in biotechnology

(2011) Inna Khozin-Goldberg et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biosynthesis of very long-chain fatty acids (C>24) in Atlantic salmon: Cloning, functional characterisation, and tissue distribution of an Elovl4 elongase

(2011) Greta Carmona-Antoñanzas et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: High activity in delta-6 desaturases of marine species

(2011) Óscar Monroig et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Influences of low salinity and dietary fatty acids on fatty acid composition and fatty acid desaturase and elongase expression in red sea bream Pagrus major

(2011) Md. Al-Amin Sarker et al.   FISHERIES SCIENCE

Widespread Occurrence of Secondary Lipid Biosynthesis Potential in Microbial Lineages

(2011) Christine N. Shulse et al.   PLoS One

Fatty acid requirements in ontogeny of marine and freshwater fish

(2010) Douglas R. Tocher   AQUACULTURE RESEARCH

Expression and role of Elovl4 elongases in biosynthesis of very long-chain fatty acids during zebrafish Danio rerio early embryonic development

(2010) Óscar Monroig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Vertebrate fatty acyl desaturase with  4 activity

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological roles of fatty acyl desaturases and elongases in marine fish: Characterisation of cDNAs of fatty acyl Δ6 desaturase and elovl5 elongase of cobia (Rachycentron canadum)

(2009) Xiaozhong Zheng et al.   AQUACULTURE

Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis

(2009) Óscar Monroig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

(2009) Chad K. Stroud et al.   JOURNAL OF LIPID RESEARCH

An alternate pathway to long-chain polyunsaturates: theFADS2gene product Δ8-desaturates 20:2n-6 and 20:3n-3

(2009) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH