Article
Endocrinology & Metabolism
Daniel J. van de Berg, Anke M. J. Kuijpers, Anton F. Engelsman, Caroline A. Drukker, Hanneke M. van Santen, Sheila C. E. J. Terwisscha van Scheltinga, A. S. Paul van Trotsenburg, Christiaan F. Mooij, Menno R. Vriens, Els J. M. Nieveen van Dijkum, Joep P. M. Derikx
Summary: This study describes the long-term oncological outcomes of pediatric papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), and finds that recurrence rate is high in pediatric PTC but low in FTC. Pediatric PTC and FTC are two distinct diseases, but both have a good survival rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Stephen Halada, Julia A. Baran, Andrew J. Bauer, Julio C. Ricarte-Filho, Amber Isaza, Tasleema Patel, Aime T. Franco, Sogol Mostoufi-Moab, N. Scott Adzick, Ken Kazahaya, Tricia R. Bhatti, Zubair Baloch, Lea F. Surrey
Summary: This study retrospectively reviewed the clinical and histological features of pediatric cases with follicular patterned thyroid nodules with nuclear features of papillary thyroid carcinoma (PTC), focusing on the invasive encapsulated follicular variant of PTC (Ienc-fvPTC) and infiltrative fvPTC (inf-fvPTC) subtypes. The study found that pediatric NIFTP and fvPTC subtypes demonstrate alignment between clinical and histological risk stratification, with indolent behavior in Ienc-fvPTC and invasive features in inf-fvPTC tumors.
Article
Anatomy & Morphology
Kun Guo, Jialiang Wang, Ling Shu, Guangjun Zhou
Summary: This study revealed that miR-200c is upregulated in human PTC tissues and associated with poor clinical prognosis. Overexpression of miR-200c promotes PTC cell proliferation, migration, and invasion while knockdown has an inhibitory effect. PTEN is identified as a downstream target of miR-200c, playing a crucial role in promoting PTC progression. Targeting the miR-200c/PTEN axis may have therapeutic significance in PTC patients.
Article
Medicine, General & Internal
Hao-Wen Chuang, Jyh-Seng Wang, Jen-Wei Tsai, Chao-Tien Hsu, Kai-Jen Lin
Summary: This study assessed the diagnostic value of various immunohistochemical markers for differentiating among benign follicular nodules, noninvasive follicular thyroid neoplasms, noninvasive encapsulated follicular variants of papillary thyroid carcinoma, and infiltrative FVPTC. Results showed specific markers with high sensitivity and specificity in distinguishing different types of lesions, with various combinations enhancing diagnostic accuracy. The similar IHC profiles of NIFTP and NEFVPTC suggest a reliable NIFTP diagnosis and a possible spectrum of progressing neoplasia.
MEDICINA-LITHUANIA
(2021)
Article
Surgery
Anna C. Beck, Anand Rajan, Shannon Landers, Sarah Kelley, Andrew M. Bellizzi, Geeta Lal, Sonia L. Sugg, James R. Howe, Carlos H. Chan, Ronald J. Weigel
Summary: The study showed that the tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. A gene signature similar to the tall cell variant identified a subtype of classic papillary thyroid carcinoma with worse recurrence-free survival.
Article
Endocrinology & Metabolism
Ping Dai, Wanjun Zhao, Xun Zheng, Han Luo, Xiaofei Wang
Summary: By analyzing data from a database, this study found that radioactive iodine therapy may not improve cancer-specific survival in patients with tall cell variant papillary thyroid cancer after total thyroidectomy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Bing Zhang, Wenming Wu, Jinjing Liu, Zhou Liang, Liang Zong
Summary: This cohort study examined the impact of different treatments on the prognosis of follicular variant papillary thyroid carcinoma (FVPTC) and classical papillary thyroid carcinoma (CPTC) patients. The findings suggest that combination therapy is associated with a decreased risk of 5-year mortality in CPTC and FVPTC patients.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Otorhinolaryngology
Xiaofei Wang, Xun Zheng, Jingqiang Zhu, Zhihui Li, Tao Wei
Summary: In this study using the SEER database, it was found that RAI did not improve disease-specific survival in patients with FVPTC without distant metastases, even in those with aggressive features. Further research involving multiple centers and prospective studies with recurrence and molecular information is needed to fully evaluate the effects of RAI on FVPTC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Xiaofeng Wang, Yanqing Bi, Xiaofang Liu, Lili Liu, Min Hao, Mengzi Tian, Jian Shang
Summary: The study found that WWP1 expression is increased in PTC tissues and cells, and its upregulation is closely correlated with clinical parameters. Knockdown of WWP1 suppressed cell proliferation, migration, and invasion in PTC cells, inducing cell cycle arrest and apoptosis. Knockdown of WWP1 also led to decreased levels of p-PI3K and p-Akt, contributing to the understanding of PTC pathogenesis.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Oncology
Shujing Li, Yanyan Zhang, Jian Dong, Ruihuan Li, Bo Yu, Wenjun Zhao, Jing Liu
Summary: LINC00893 is lowly expressed in thyroid carcinoma tissues and acts as a tumor suppressor in papillary thyroid carcinoma (PTC) by inhibiting cell proliferation and migration through modulation of the PTEN/AKT pathway.
Article
Medicine, Research & Experimental
David Zimmer, Gilman Plitt, Brandon Prendes, Jamie Ku, Natalie Silver, Eric Lamarre, Emrullah Yilmaz, Jessica Geiger, Christian Nasr, Lea El Hage, Mario Skugor, Shauna Cambpell, Shlomo Koyfman, Jacob Miller, Neil Woody, Katherine Heiden, Nikhil Joshi, Tarik Elsheikh, Hong Li, Joseph Scharpf
Summary: This study aimed to test the application of an established dynamic risk stratification tool in patients with TCV to better predict postoperative outcomes. The results showed that patients with TCV who had an excellent overall response to treatment had lower rates of recurrence, disease persistence, need for additional intervention, and disease-specific mortality.
Article
Biotechnology & Applied Microbiology
Jing He, Mingxia Zhou, Jie Yin, Junhu Wan, Jie Chu, Jinlin Jia, Jinxiu Sheng, Chang Wang, Huiqing Yin, Fucheng He
Summary: The RNA modification N6-methyladenosine (m6A) plays a crucial role in papillary thyroid carcinoma (PTC) by regulating the tumor-suppressive effects of METTL3 on c-Rel and RelA. Additionally, METTL3 disruption leads to IL-8 secretion and altered recruitment of tumor-associated neutrophils (TANs), affecting tumor growth and metastasis.
Article
Endocrinology & Metabolism
Carlotta Giani, Liborio Torregrossa, Teresa Ramone, Cristina Romei, Antonio Matrone, Eleonora Molinaro, Laura Agate, Gabriele Materazzi, Paolo Piaggi, Clara Ugolini, Fulvio Basolo, Raffaele Ciampi, Rossella Elisei
Summary: This study found that the integrity of the whole tumor capsule in CVPTC is associated with prognosis, with En-CVPTC showing similar clinical/pathological behavior to En-FVPTC despite lower prevalence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yongyue Zhang, Fang Mei, Xiaoxi He, Jing Ma, Shumin Wang
Summary: This study aimed to investigate the relationship between sonographic features and histological manifestations in the tall-cell variant of papillary thyroid microcarcinoma (TCV-PTMC). The study proposed the concept of sonographic histology and examined its value in the clinical management of TCV-PTMC. The results showed that hypoechoic nodules with a localized central isoechoic lesion and hypoechoic halo around nodules were commonly observed in TCV-PTMC, correlating with specific histopathological features. TCV-PTMC also displayed more regular margins and less microcalcification compared to classical PTMC, leading to a potential underestimation of the risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Xueqi Zhang, Fan Zhang, Qiuxian Li, Chuyao Feng, Weiping Teng
Summary: The reasons for the increasing incidence of thyroid cancer are unclear, but lifestyle, environmental factors, and complications may play a role. Iodine intake may affect papillary thyroid carcinoma, but the available evidence is limited due to various factors.
FRONTIERS IN NUTRITION
(2022)
Review
Genetics & Heredity
Giang T. Lam, Sarita Prabhakaran, Alexandra Sorvina, Carmela Martini, Ben S. -Y. Ung, Litsa Karageorgos, Shane M. Hickey, Joanna Lazniewska, Ian R. D. Johnson, Desmond B. Williams, Sonja Klebe, Victoria Malone, John J. O'Leary, Louise Jackett, Doug A. Brooks, Jessica M. Logan
Summary: Accurate diagnosis of melanoma is crucial for patient outcomes. However, subjective interpretation of histopathologic analysis and the difficulty in distinguishing melanoma from benign lesions using immunohistochemistry pose challenges. The lack of specific biomarkers further complicates accurate diagnosis.
MOLECULAR DIAGNOSIS & THERAPY
(2023)
Article
Endocrinology & Metabolism
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Nabil Siraj, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study retrospectively analyzed 1283 patients with papillary thyroid carcinoma (PTC) and found a high incidence of bilateral multifocality. Bilateral multifocality was closely associated with clinical pathological characteristics such as age, gender, tumor size, and lymph node metastasis. It was also identified as an independent predictor of PTC recurrence. Therefore, patients with bilateral multifocal PTC may benefit from more frequent follow-up to detect recurrences earlier.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Roxanne Diaz, Saravanan Thangavel, Rafia Begum, Wael Haqawi, Falah Hassan Al-Mohanna, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study investigated the expression and functional role of furin in Middle Eastern papillary thyroid carcinoma (PTC). Furin overexpression was observed in 44.6% of PTC cases and was associated with aggressive clinicopathological parameters and poor outcomes. Knockdown of FURIN suppressed tumor growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in BRAF mutant cells, while overexpression of FURIN reversed these effects in BRAF wild-type cells. FURIN inhibition showed a synergistic antitumor effect with anti-MEK inhibitor treatment.
MOLECULAR ONCOLOGY
(2023)
Article
Pathology
Alexandra Sorvina, Carmela Martini, Sarita Prabhakaran, Jessica M. Logan, Benjamin S-Y. Ung, Courtney Moore, Ian R. D. Johnson, Joanna Lazniewska, Prerna Tewari, Victoria Malone, Robert D. Brooks, Shane M. Hickey, Maria C. Caruso, Sonja Klebe, Litsa Karageorgos, John J. O'leary, Brett Delahunt, Hemamali Samaratunga, Doug A. Brooks
Summary: The presence of intraductal carcinoma of the prostate (IDCP) is associated with late-stage disease and poor outcomes. However, accurately assessing disease severity remains a challenge. Current markers have limited utility in characterizing the complex biology of IDCP.
Article
Multidisciplinary Sciences
Abdul K. K. Siraj, Rong Bu, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Maha Al-Rasheed, Wael Haqawi, Mark Diaz, Ingrid G. G. Victoria, Ismail A. A. Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. S. Al-Kuraya
Summary: By screening 918 breast cancer/ovarian cancer patients from Saudi Arabia, we identified six cases with pathogenic/likely pathogenic variants in the PALB2 gene, accounting for 0.65% of the entire cohort. Among these cases, two carried pathogenic variants and four carried likely pathogenic variants. All affected carriers had breast cancer, with a median age of diagnosis at 39.5 years, and only two cases had a documented family history of cancer.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jessica M. Logan, Ashley M. Hopkins, Carmela Martini, Alexandra Sorvina, Prerna Tewari, Sarita Prabhakaran, Chelsea Huzzell, Ian R. D. Johnson, Shane M. Hickey, Ben S. -Y. Ung, Joanna Lazniewska, Robert D. Brooks, Courtney R. Moore, Maria C. Caruso, Litsa Karageorgos, Cara M. Martin, Sharon O'Toole, Laura Bogue Edgerton, Mark P. Ward, Mark Bates, Stavros Selemidis, Adrian Esterman, Sheena Heffernan, Helen Keegan, Sarah Ni Mhaolcatha, Roisin O'Connor, Victoria Malone, Marguerite Carter, Katie Ryan, Andres Clarke, Nathan Brady, Sonja Klebe, Hemamali Samaratunga, Brett Delahunt, Michael J. Sorich, Kim Moretti, Lisa M. Butler, John J. O'Leary, Douglas A. Brooks
Summary: A novel biomarker panel (Appl1, Sortilin and Syndecan-1) was found to be a strong independent predictor for both clinical and biochemical recurrence outcomes, with higher prediction performance than traditional grading. The study also found that biomarker-assisted assessment had better predictive performance for evaluating the risk of biochemical recurrence and clinical recurrence in patients with prostate cancer.
Article
Pathology
Prudence A. Russell, Alexandra L. Farrall, Sarita Prabhakaran, Khashayar Asadi, Wade Barrett, Caroline Cooper, Wendy Cooper, Samuel Cotton, Edwina Duhig, Matthew Egan, Stephen Fox, David Godbolt, Shilpa Gupta, Aniza Hassan, Connull Leslie, Trishe Leong, David Moffat, Min Ru Qiu, Vanathi Sivasubramaniam, Joanna Skerman, Cameron Snell, Michael Walsh, Karen Whale, Sonja Klebe
Summary: This study investigated the real-world prevalence of programmed death ligand-1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC) in Australia. The findings revealed associations between PD-L1 expression and gender, age, and tumor stage. Additionally, significant differences were observed among different sample types, such as cytology and biopsy samples.
Correction
Pathology
Carmela Martini, Jessica M. Logan, Alexandra Sorvina, Sarita Prabhakaran, Benjamin S-Y. Ung, Ian R. D. Johnson, Shane M. Hickey, Robert D. Brooks, Maria C. kConFab Consortium, Maria C. Caruso, Sonja Klebe, Litsa Karageorgos, John J. O'Leary, Brett Delahunt, Hemamali Samaratunga, Douglas A. Brooks
Article
Multidisciplinary Sciences
Joanna Lazniewska, Ka Lok Li, Ian R. D. Johnson, Alexandra Sorvina, Jessica M. Logan, Carmela Martini, Courtney Moore, Ben S. -Y. Ung, Litsa Karageorgos, Shane M. Hickey, Sarita Prabhakaran, Jessica K. Heatlie, Robert D. Brooks, Chelsea Huzzell, Nicholas I. Warnock, Mark P. Ward, Bashir Mohammed, Prerna Tewari, Cara Martin, Sharon O'Toole, Laura Bogue Edgerton, Mark Bates, Paul Moretti, Stuart M. Pitson, Stavros Selemidis, Lisa M. Butler, John J. O'Leary, Douglas A. Brooks
Summary: The development and progression of prostate cancer are closely related to the regulation of glucose and lipid metabolism, as well as alterations in androgen receptor expression and signaling. This study reveals a previously unrecognized molecular mechanism for prostate cancer, which involves the dynamic balance between sortilin and syndecan-1 and their impact on different metabolic phenotypes. In androgen-sensitive cells, sortilin enhances glucose metabolism while limiting lipid metabolism, whereas in androgen-insensitive cells, syndecan-1 promotes lipid metabolism. Additionally, androgen-deprived cells show decreased expression of sortilin and increased expression of syndecan-1, contributing to altered glucose and lipid metabolism. These findings have important implications for understanding disease progression and castration-resistant prostate cancer in the context of androgen-deprivation therapy.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Giang T. Lam, Alexandra Sorvina, Carmela Martini, Sarita Prabhakaran, Ben S. -Y. Ung, Joanna Lazniewska, Courtney R. Moore, Andrew R. Beck, Ashley M. Hopkins, Ian R. D. Johnson, Maria C. Caruso, Shane M. Hickey, Robert D. Brooks, Louise Jackett, Litsa Karageorgos, Erwin J. Foster -Smith, Victoria Malone, Sonja Klebe, John J. O'Leary, Douglas A. Brooks, Jessica M. Logan
Summary: Cutaneous melanoma is a lethal form of skin tumor. Current detection methods based on melanin visualization cannot reliably distinguish between different types of lesions. This study investigates the involvement of the endosomal-lysosomal system in melanoma and identifies dysregulated genes associated with this system, which may serve as potential markers for differentiating melanoma from other skin cancers.
Article
Oncology
Rong Bu, Abdul K. Siraj, Saud Azam, Kaleem Iqbal, Zeeshan Qadri, Maha Al-Rasheed, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study identified a strong association between GALNT9 gene and rare inactivating variants in Middle Eastern population with Papillary thyroid carcinoma (PTC), and also found several other genes associated with PTC risk. The study highlights the potential role of GALNT9 and other genes in PTC predisposition and emphasizes the need for large collaborations and innovative approaches to understand the genetic heterogeneity of PTC predisposition.
Article
Oncology
Giang T. Lam, Carmela Martini, Tiffany Brooks, Sarita Prabhakaran, Ashley M. Hopkins, Ben S. -Y. Ung, Jingying Tang, Maria C. Caruso, Robert D. Brooks, Ian R. D. Johnson, Alexandra Sorvina, Shane M. Hickey, Litsa Karageorgos, Sonja Klebe, John J. O'Leary, Douglas A. Brooks, Jessica M. Logan
Summary: Early diagnosis is crucial for improving outcomes in melanoma patients, and this study aims to understand the challenges faced by clinicians in assessing melanoma cases and provide insights for future research. The survey results indicate the need for new biomarkers and the use of multiple immunohistochemistry markers to improve diagnostic accuracy in melanoma assessment.