Journal
BRITISH JOURNAL OF CANCER
Volume 113, Issue 1, Pages 182-192Publisher
SPRINGERNATURE
DOI: 10.1038/bjc.2015.149
Keywords
head and neck cancer; INHANCE; laryngeal cancer; oral and pharyngeal cancer; vitamin E
Categories
Funding
- National Institutes of Health (NIH), National Cancer Institute, (NCI) [R03CA113157]
- NIDCR [R03DE016611]
- Italy Multicenter study: Italian Association for Research on Cancer (AIRC)
- Italy Multicenter study: Italian League Against Cancer
- Italy Multicenter study: Italian Ministry of Research
- Swiss study: Swiss Research against Cancer/Oncosuisse [KFS-700, OCS-1633]
- Los Angeles study: NIH [P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667]
- Los Angeles study: Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center
- Boston study: NIH [R01CA078609, R01CA100679]
- US multicenter study: Intramural Program of the NCI, NIH, USA
- MSKCC study: NIH [R01CA051845]
- Japan study: Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan [20012005, 17015052]
- North Carolina study
- Buffalo study
- Milan study: Italian Association for Cancer Research (AIRC) [10068]
- Milan study: Italian Foundation for Cancer Research (FIRC)
- Milan study: Italian Ministry of Education [PRIN 2009 X8YCBN]
- FIRC
- Japan study: Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [20012005, 17015052] Funding Source: KAKEN
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Background: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited. Methods: We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake. Results: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category = 0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR = 0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites. Conclusion: Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.
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