Article
Medicine, Research & Experimental
Jing Xun, Lingfang Du, Ruifang Gao, Long Shen, Dekun Wang, Lichun Kang, Chuan'ai Chen, Zhujun Zhang, Yuying Zhang, Shijing Yue, Shuxin Feng, Rong Xiang, Xue Mi, Xiaoyue Tan
Summary: This study demonstrates that miR-138-5p delivered from breast cancer cells to tumor-associated macrophages via exosomes can downregulate KDM6B expression, inhibit M1 polarization, and stimulate M2 polarization, ultimately promoting tumor metastasis. Additionally, exosomal miR-138-5p levels positively correlate with the progression of breast cancer, suggesting it as a potential prognostic marker and therapeutic target.
Article
Virology
Aunji Pradhan, Ashish Aneja, Sahana Ghosh, Himadri Devvanshi, C. Deepika, Risabh Sahu, Celil Ross, Pallavi Kshetrapal, Arindam Maitra, Saumitra Das
Summary: In this study, the role of exosomal miRNAs in dengue virus-induced disease progression was analyzed in an Indian cohort. After comprehensive analysis, miR-96-5p was found to be upregulated while miR-146a-5p was downregulated with the progression of disease to severe form. The expression levels of miR-96-5p and miR-146a-5p were strongly correlated with platelet levels. Additionally, miR-146a-5p was found to regulate the expression of proteins involved in immune responses.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Biochemistry & Molecular Biology
Ke Li
Summary: This study revealed that miR-509-3-5p regulates the malignancy of colon cancer by suppressing target gene GTSE1. Downregulation of miR-509-3-5p in CC and its overexpression can inhibit the proliferation, migration, and invasion of CC cells. MiR-509-3-5p targets GTSE1, identified as an oncogene in colon cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Minsung Kim, Il Tae Son, Gyoung Tae Noh, So-Youn Woo, Ryung-Ah Lee, Bo Young Oh
Summary: This study investigated the role of colon cancer-cell-derived exosomes in colon cancer. The results showed that exosome treatment significantly increased cancer cell proliferation, altered cell adhesion molecule expression, enhanced cell motility, and had an impact on the gene regulation of cancer-associated fibroblasts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hsien-Ming Wu, Tzu-Chi Lo, Chia-Lung Tsai, Liang-Hsuan Chen, Hong-Yuan Huang, Hsin-Shih Wang, John Yu
Summary: This study investigates the involvement of miR-138-5p and GPR124 in NLRP3 inflammasome activation during embryo implantation and early pregnancy. The results indicate that these factors play important roles in decidual programming and placentation, suggesting their potential as modulators in human pregnancy.
Review
Biochemistry & Molecular Biology
Valeria Arcucci, Steven A. Stacker, Marc G. Achen
Summary: Non-coding RNAs play crucial roles in regulating tumor angiogenesis and lymphangiogenesis, as they can be delivered to endothelial cells through exosomes to promote tumor metastasis and progression. These molecules have the potential to serve as cancer biomarkers and may offer opportunities for cancer therapy.
Article
Cardiac & Cardiovascular Systems
Guo-wei Tu, Jie-fei Ma, Jia-kun Li, Ying Su, Jing-chao Luo, Guang-wei Hao, Ming-hao Luo, Yi-rui Cao, Yi Zhang, Zhe Luo
Summary: The miR-885-5p/HMBOX1 axis plays a significant role in septic myocardial depression. Sepsis-exos promote pyroptosis in AC16 cells through miR-885-5p, and HMBOX1 reverses this effect in an NF-kappa B-dependent manner.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Aixia Lv, Zengrong Tu, Yunhua Huang, Weiying Lu, Baoguo Xie
Summary: The study found that exosomal miR-125a-5p expression levels were significantly lower in patients with cervical cancer compared to healthy controls, suggesting it could serve as a potential biomarker for cervical cancer diagnosis. Further research with larger sample sizes is needed to validate the conclusions of this study.
Article
Biotechnology & Applied Microbiology
Ruliang Ding, Weiwen Hong, Liang Huang, Jinfan Shao, Wenfeng Yu, Xijuan Xu
Summary: MicroRNA-145-5p represses colon cancer cell cycle progression and cell proliferation by targeting PSAT1.
Article
Multidisciplinary Sciences
Sarah Hamdy Ahmed, Nancy A. Espinoza-Sanchez, Ahmed El-Damen, Sarah Atef Fahim, Mohamed A. Badawy, Burkhard Greve, Mohamed El-Shinawi, Martin Goette, Sherif Abdelaziz Ibrahim
Summary: Inflammatory breast cancer is a rare but aggressive form of breast cancer that can be diagnosed through miRNAs in small extracellular vesicles in the blood, with certain miRNAs found to be associated with the cancer. Analyzing these miRNAs can serve as promising diagnostic biomarkers for IBC.
Article
Biotechnology & Applied Microbiology
Kun Liu, Xin Luo, Zhao-Yong Lv, Yu-Jue Zhang, Zhen Meng, Jun Li, Chun-Xiu Meng, Hui-Fen Qiang, Cai-Yao Hou, Lei Hou, Feng-Zhen Liu, Bin Zhang
Summary: The effective healing of bone defects relies on the coordination between inflammatory and bone-forming cells. This study investigated the interaction between polarized macrophages and bone mesenchymal stem cells (BMSCs), as well as their effects on osteogenesis. The results showed that exosomes from both pro-inflammatory M1 and anti-inflammatory M2 macrophages can promote the osteogenesis of BMSCs, especially M1 macrophage-derived exosomes through microRNA-21a-5p in the early stage of inflammation. This research helps us understand the complex interactions between BMSCs and macrophages, and provides insights for improving bone healing and other regenerative processes through the release of exosomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li, Xiaoke Su
Summary: The study revealed that UCA1 regulates SOX2 expression by sponging miR-122-5p, affecting the functions of CC stem cells, while CaSki-Exo promotes the invasion and migration of CC stem cells. Silencing UCA1 or up-regulating miR-122-5p reduced the invasion and migration abilities of CC stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
Shuoshuo Ma, Wenjing Wang, Dengyong Zhang, Guanru Zhao, Zheng Lu
Summary: Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs that have a length of over 200 nucleotides. Abnormal expression of lncRNA CCAT2 has been found in various tumors and is associated with cell behaviors and prognostic factors. This article provides a comprehensive review of the biological functions and mechanisms of action of CCAT2 in tumors, aiming to support its future clinical applications.
CHINESE MEDICAL JOURNAL
(2022)
Article
Cell Biology
Junling Zhang, Xiaocong Pang, Lili Lei, Jixin Zhang, Xiaoqian Zhang, Ziyi Chen, Jing Zhu, Yong Jiang, Guowei Chen, Yingchao Wu, Tao Wu, Yisheng Pan, Yucun Liu, Yimin Cui, Xin Wang
Summary: CRART16 is highly expressed in gastric cancer tissues and correlates with advanced tumor stages and poor prognosis. It promotes angiogenesis in gastric cancer by downregulating miR-122-5p, upregulating FOS, and increasing VEGFD expression.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
