Article
Gastroenterology & Hepatology
Yosuke Namba, Tsuyoshi Kobayashi, Masakazu Hashimoto, Takashi Onoe, Hiroaki Mashima, Koichi Oishi, Naruhiko Honmyo, Tomoyuki Abe, Shintaro Kuroda, Hideki Ohdan
Summary: This study evaluated the safety of laparoscopic liver resection in hepatocellular carcinoma patients aged >= 80 years. The results showed that laparoscopic liver resection is a safe and feasible option in this age group, with lower rates of intraoperative bleeding and cardiopulmonary complications.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Medicine, General & Internal
Hee Jung Son, Young-Hoon Jo, Hyung Seob Ahn, Jooyoung You, Chang-Nam Kang
Summary: This study compared the outcomes and complications of lumbar spinal fusion for degenerative lumbar spinal stenosis in super-elderly patients (80 years and over) with those in elderly patients (65 years and over, and under 80 years). Results showed no significant differences between the two groups in preoperative and postoperative measures, but the super-elderly group had higher K-ODI scores. Postoperative delirium was more common in the super-elderly group, with SE status identified as a risk factor. Overall, spinal fusion surgery is effective for improving quality of life in super-elderly patients with DLSS, but careful perioperative management is necessary to prevent postoperative delirium.
Article
Surgery
Darren W. Chua, Nicholas Syn, Ye-Xin Koh, Jin-Yao Teo, Peng-Chung Cheow, Alexander Y. F. Chung, Chung-Yip Chan, Brian K. P. Goh
Summary: This study analyzed the effects of body mass index (BMI) and standardized liver volume (SLV) on outcomes in minimally invasive liver resections (MILR). The results showed that high BMI and SLV were associated with increased blood loss and operative conversions, while low BMI was associated with a higher risk of major complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Luke D. Rothermel, Benjamin D. Powers, Margaret M. Byrne, Kevin McCarthy, Jason W. Denbo, Jasmina Ehab, Jason B. Fleming, Daniel A. Anaya
Summary: Background Parenchyma-sparing (PS) liver resection is recommended for liver tumors, and the value-based differences between PS approaches and more extended resections are still unclear.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Brian K. P. Goh, Nicholas Syn, Ser-Yee Lee, Ye-Xin Koh, Jin-Yao Teo, Juinn-Huar Kam, Peng-Chung Cheow, Prema-Raj Jeyaraj, Pierce K. Chow, London L. Ooi, Alexander Y. Chung, Chung-Yip Chan
Summary: The presence of liver cirrhosis significantly affects both the intraoperative technical difficulty and postoperative outcomes of MILR, suggesting that cirrhosis should be considered an important parameter in future difficulty scoring systems for MILR.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Brian K. P. Goh, Ho-Seong Han, Kuo-Hsin Chen, Darren W. Chua, Chung-Yip Chan, Federica Cipriani, Davit L. Aghayan, Asmund A. Fretland, Jasper Sijberden, Mizelle D'Silva, Tiing Foong Siow, Yutaro Kato, Chetana Lim, Phan Phuoc Nghia, Paulo Herman, Marco Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Mengqui Yin, Zewei Chen, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo R. Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago F. Lopez-Ben, Fabricio F. Coelho, Thomas Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni B. Levi Sandri, Mansour Saleh, Daniel Cherqui, Olivier Scatton, Olivier Soubrane, Go I. Wakabayashi, Roberto Troisi, Tan-To Cheung, Atsushi Sugioka, Mohammad Abu Hilal, David Fuks, Bjorn Edwin, Luca Aldrighetti
Summary: This study established global benchmark outcomes for laparoscopic liver resections (L-LR) by analyzing a multicenter database of 11,983 patients. Three specific procedures were selected and 15 outcome indicators were established as benchmark cutoffs. The results provide an objective assessment of performance gaps and learning curves for centers adopting L-LR.
Article
Oncology
Federica Cipriani, Luca Aldrighetti, Francesca Ratti, Andrew G. R. Wu, Tousif Kabir, Olivier Scatton, Chetana Lim, Wanguang Zhang, Jasper Sijberden, Davit L. Aghayan, Tiing-Foong Siow, Safi Dokmak, Fabricio Ferreira Coelho, Paulo Herman, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung-Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Salvatore Gruttadauria, Alejandro Mejia, James O. Park, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric C. H. Lai, Charing C. N. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T. Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Yutaro Kato, Atsushi Sugioka, Ho-Seong Han, Tran Cong duy Long, Qu Liu, Rong Liu, Bjorn Edwin, David Fuks, Kuo-Hsin Chen, Mohammad Abu Hilal, Brian K. P. Goh
Summary: Cirrhosis affects the difficulty and outcomes of minimally invasive liver resections, with more advanced cirrhosis resulting in higher blood transfusion rates, increased postoperative morbidity, and longer hospitalization.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Yvette Chong, Ye-Xin Koh, Jin-Yao Teo, Peng-Chung Cheow, Pierce K. Chow, Alexander Y. Chung, Chung-Yip Chan, Brian K. P. Goh
Summary: The study found that patients with previous non-liver-related abdominal surgery undergoing MILR did not have inferior outcomes compared to patients without previous abdominal surgery. Measures of operative difficulty and complication rates were comparable between the two groups and subgroups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Ying Xing, Zheng-Rong Liu, Wei Yu, Hong-Yi Zhang, Mao-Min Song
Summary: The study found that preoperative total bilirubin, platelets, APRI, and SV/LV are independent risk factors for PHLF in patients undergoing liver tumor resection, significantly affecting prognosis.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Surgery
Susumu Eguchi, Masaaki Hidaka, Tota Kugiyama, Akihiko Soyama, Takanobu Hara, Kantoku Nagakawa, Tomohiko Adachi, Takayuki Tanaka, Tomoko Yoshimoto, Takashi Hamada, Hajime Matsushima, Sinichiro Ito, Kengo Kanetaka
Summary: Over 20 years, there have been notable changes in the baseline characteristics and modes of LR for HCC patients. The aging of patients, increased incidence of HCC from non-B, non-C liver cirrhosis, and the significant rise of laparoscopic surgeries in recent years are important findings. Additionally, outcomes in terms of patient survival and recurrence-free survival at 5 years after LR have shown improvement in the later era.
WORLD JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Katharina Hoeter, Stefan Heinrich, Daniel Wollschlaeger, Felix Melchior, Anna Noack, Verena Tripke, Hauke Lang, Serge C. Thal, Dorothee H. Bremerich
Summary: Optimal fluid management in liver surgery has not been established. A retrospective analysis of 666 liver resections revealed that fluid management was not associated with overall postoperative morbidity, but the normal fluid management group had shorter postoperative hospital stays, ICU stays, and lower in-hospital mortality. Predictive factors for postoperative morbidity included elevated lactate levels, duration, and extent of surgery. In the subgroup of major/extreme liver resection, very low total and normalized fluid balance were associated with morbidity. Fluid management was not associated with morbidity in patients with normal lactate levels. Hence, fluid management in liver surgery should be judiciously applied to avoid hypovolemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Osamu Yoshino, Yifan Wang, Frances McCarron, Benjamin Motz, Huaping Wang, Erin Baker, David Iannitti, John B. B. Martinie, Dionisios Vrochides
Summary: Robotic surgery is not commonly used for hepato-pancreato-biliary procedures, but we hypothesized that it would be beneficial for elderly patients undergoing major hepatectomy. Our study found that robotic hepatectomy had advantages over laparoscopic hepatectomy in terms of shorter hospital and ICU stays, potentially overcoming the perceived financial burden.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Qian Wang, Hua-jian Li, Xiao-ming Dai, Zhi-qiang Xiang, Zhu Zhu
Summary: In elderly patients with HCC, LLR was associated with better surgical outcomes than OLR, but there was no significant difference in oncological outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Seok Oh, Ju Han Kim, Cho-Hee Hwang, Dae Young Hyun, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong
Summary: This study compared the clinical characteristics and outcomes of patients aged 65-79 years and >= 80 years who underwent TAVR for aortic stenosis, finding differences in obesity, diabetes, surgical risk, creatinine clearance, hematocrit level, and effective orifice area between the two groups. Despite these differences, there was no significant variation in in-hospital clinical outcomes between elderly and super-elderly patients, demonstrating that advanced age does not impact the safety outcomes of TAVR procedures.
Article
Surgery
Christian Hobeika, Ecoline Tribillon, Ugo Marchese, Nicole Faermark, Abdessalem Ghedira, Stephane Bonnet, Alexandra Nassar, Brice Gayet, David Fuks
Summary: The study found that the Institut Mutualiste Montsouris classification is a valuable difficulty scoring system for laparoscopic repeat liver resections procedures. Additionally, previous major resection and presence of sinusoidal obstruction syndrome are independent risk factors of unexpected difficulty.
Article
Surgery
Tomoaki Yoh, Takamichi Ishii, Takahiro Nishio, Yukinori Koyama, Satoshi Ogiso, Ken Fukumitsu, Yoichiro Uchida, Takashi Ito, Satoru Seo, Koichiro Hata, Etsuro Hatano
Summary: This study aims to propose and validate a resectability classification for hepatocellular carcinoma (HCC) in the era of multidisciplinary treatment. The results show that this classification can stratify survival outcomes of HCC and help determine treatment strategies.
WORLD JOURNAL OF SURGERY
(2023)
Editorial Material
Oncology
Zorays Moazzam, Laura Alaimo, Yutaka Endo, Henrique A. A. Lima, Chanza P. F. Shaikh, Francesca Ratti, Hugo P. P. Marques, Francois Cauchy, Vincent Lam, George A. A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M. M. Pawlik
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Laura Alaimo, Zorays Moazzam, Yutaka Endo, Henrique A. Lima, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Laura Alaimo, Zorays Moazzam, Yutaka Endo, Henrique A. Lima, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: This study identified three distinct subtypes of intrahepatic cholangiocarcinoma (ICC) based on tumor burden score (TBS), preoperative neutrophil-to-lymphocyte ratio (NLR), and CA19-9 levels. These subtypes were associated with significant differences in recurrence-free survival (RFS) and overall survival (OS). Despite having more favorable tumor burden and lymphocyte ratio, the inflammatory subtype of ICC had a higher incidence of recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Zorays Moazzam, Laura Alaimo, Yutaka Endo, Henrique A. Lima, Chanza F. Shaikh, Francesca Ratti, Hugo P. Marques, Francois Cauchy, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M. Pawlik
Summary: This study investigated the postoperative oncologic outcomes in patients with early and intermediate hepatocellular carcinoma (HCC) and found that patients with intermediate HCC were less likely to achieve textbook oncologic outcomes. Factors such as tumor burden, aspartate transaminase-platelet ratio index, Charlson Comorbidity Index, major liver resection, and tumor stage were identified as influencing factors for textbook oncologic outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yutaka Endo, Kazunari Sasaki, Zorays Moazzam, Henrique A. Lima, Laura Alaimo, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Minoru Kitago, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: This study aimed to investigate the prognostic significance of margin status following hepatectomy of intrahepatic cholangiocarcinoma (ICC). The results showed that increasing margin width was associated with improved survival in patients with low or medium tumor burden, while margin status did not impact prognosis in patients with high tumor burden.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Xu-Feng Zhang, Feng Xue, Matthew Weiss, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Francois Cauchy, Guillaume Martel, B. Groot Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik
Summary: The unique lateral patterns of lymphatic drainage impact lymph node metastasis and long-term survival of patients with left- versus right-sided intrahepatic cholangiocarcinoma (ICC) undergoing lymphadenectomy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yoichiro Uchida, Tomoaki Yoh, Ayaka Fukui, Atsushi Takai, Etsuro Hatano
Summary: A 74-year-old man with advanced hepatocellular carcinoma (HCC) who underwent atezolizumab plus bevacizumab followed by radical hepatectomy showed a complete metabolic response assessed by F-18-FDG PET/CT. Pathological examination further revealed a complete response of the tumor to this therapy. This case suggests that F-18-FDG PET/CT has clinical relevance as a useful approach for evaluating the therapeutic response of immune-oncology drugs in HCC.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Muhammad Musaab Munir, Yutaka Endo, Henrique A. Lima, Laura Alaimo, Zorays Moazzam, Chanza Shaikh, George A. Poultsides, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, Minoru Kitago, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: This study examined the prognostic role of tumor burden score (TBS) relative to albumin-bilirubin (ALBI) grade among patients undergoing curative-intent resection of intrahepatic cholangiocarcinoma (ICC). The results showed that decreased tumor burden was associated with better long-term outcomes. Patients with high TBS and high ALBI grade had worse overall survival and higher risk of early recurrence and death.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Benjamin Picard, Stephanie Sigaut, Olivier Roux, Paer-Selim Abback, Pierre-Marie Choinier, Marina Hachouf, Mikhael Giabicani, Juliette Kavafyan, Claire Francoz, Federica Dondero, Mickael Lesurtel, Francois Durand, Francois Cauchy, Catherine Paugam-Burtz, Souhayl Dahmani, Emmanuel Weiss
Summary: The aim of this study was to evaluate the risk/benefit-balance of transcranial Doppler (TCD) use in patients with acute liver failure (ALF) and hepatic encephalopathy (HE) due to intracranial hypertension (ICH). The results suggest that TCD may be a useful non-invasive tool for ICH detection, management and guiding sedation withdrawal in ALF patients.
CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Ken Fukumitsu, Takamichi Ishii, Satoshi Ogiso, Tomoaki Yoh, Yoichiro Uchida, Takashi Ito, Satoru Seo, Koichiro Hata, Shinji Uemoto, Etsuro Hatano
Summary: In this prospective clinical trial, patient-specific 3D-printed liver models were evaluated as an intraoperative navigation system for hepatobiliary surgery. The models accurately reflected patients' original data and improved safety and reduced psychological stress during operations.
Article
Surgery
Tomoaki Yoh, Takamichi Ishii, Satoshi Ogiso, Hiroto Nishino, Takahiro Nishio, Yukinori Koyama, Yoichiro Uchida, Takashi Ito, Etsuro Hatano
Summary: This study retrospectively analyzed patients with intermediate and advanced-stage hepatocellular carcinoma who underwent liver resection. The results showed that although liver resection alone may not lead to remission in most patients, active salvage therapy can potentially prolong survival. Further research is warranted to decrease recurrence rates and increase salvageability for these patients.
Article
Surgery
Nguyen Hai Nam, Tomoaki Yoh, Yutaro Hori, Koshiro Morino, Hiroto Nishino, Takahiro Nishio, Yukinori Koyama, Satoshi Ogiso, Kazuyuki Nagai, Ken Fukumitsu, Yoichiro Uchida, Takashi Ito, Takamichi Ishii, Satoru Seo, Koichiro Hata, Kojiro Taura, Etsuro Hatano
Summary: This study investigated the impact of liver volumetric regeneration (LVR) on long-term outcomes in patients with hepatocellular carcinoma (HCC) undergoing major hepatectomy. The results showed that the LVR-index was associated with overall survival (OS) and could serve as a prognostic indicator.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Kosuke Tanaka, Satoshi Ogiso, Tomoaki Yoh, Ahmed Hussein Abdelhafez, Yuki Masano, Shinya Okumura, Shoichi Kageyama, Takashi Ito, Koichiro Hata, Etsuro Hatano
Summary: This study aims to explore the relationship between donor body shape and surgical outcomes of laparoscopic-assisted donor hepatectomy (LADH). The study found that thoracic depth is associated with massive blood loss in right-lobe donors, and anthropometric parameters are helpful for predicting surgical outcomes.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Editorial Material
Oncology
Laura Alaimo, Zorays Moazzam, Yutaka Endo, Henrique A. Lima, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
ANNALS OF SURGICAL ONCOLOGY
(2023)