The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

Suppression of β-Lactam Resistance by Aspergillomarasmine A is Influenced by Both the Metallo-β-Lactamase Target and the Antibiotic Partner

(2020) Caitlyn M. Rotondo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology of β-Lactamase-Producing Pathogens

(2020) Karen Bush et al.   CLINICAL MICROBIOLOGY REVIEWS

Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

(2020) Ruslan Tsivkovski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

(2020) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission

(2020) Maya L. Nadimpalli et al.   Nature Microbiology

Bacterial Pneumonia in COVID-19 Critically Ill Patients: A Case Series

(2020) Emmanuel Dudoignon et al.   CLINICAL INFECTIOUS DISEASES

Repurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients

(2020) Matthew W. Davis et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

(2020) Antonela R. Palacios et al.   Biomolecules

COVID-19 Response in Latin America

(2020) Patricia J. Garcia et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Update on the epidemiology of carbapenemases in Latin America and the Caribbean

(2020) Juan Carlos García-Betancur et al.   Expert Review of Anti-Infective Therapy

Interplay between β-lactamases and new β-lactamase inhibitors

(2019) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Geographical and temporal variation in the frequency and antimicrobial susceptibility of bacteria isolated from patients hospitalized with bacterial pneumonia: results from 20 years of the SENTRY Antimicrobial Surveillance Program (1997–2016)

(2019) Helio S Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings

(2019) Wenjing Wu et al.   CLINICAL MICROBIOLOGY REVIEWS

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

(2019) Catherine L. Tooke et al.   JOURNAL OF MOLECULAR BIOLOGY

Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria

(2019) Patrice Nordmann et al.   CLINICAL INFECTIOUS DISEASES

Protein determinants of dissemination and host specificity of metallo-β-lactamases

(2019) Carolina López et al.   Nature Communications

The threat of carbapenem-resistant bacteria in the environment: Evidence of widespread contamination of reservoirs at a global scale

(2019) Molly C. Mills et al.   ENVIRONMENTAL POLLUTION

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

(2019) Bin Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transition Metal Sequestration by the Host-Defense Protein Calprotectin

(2018) Emily M. Zygiel et al.   Annual Review of Biochemistry

Carbapenem-resistant Enterobacteriaceae in wildlife, food-producing, and companion animals: a systematic review

(2018) R. Köck et al.   CLINICAL MICROBIOLOGY AND INFECTION

Tebipenem, the first oral carbapenem antibiotic

(2018) Michael J. Pucci et al.   Expert Review of Anti-Infective Therapy

Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: effects of NDM mutations on stability, zinc affinity, mono-zinc activity

(2018) Zishuo Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

(2018) Runming Wang et al.   Nature Communications

Acinetobacter baumannii transfers the blaNDM-1 gene via outer membrane vesicles

(2017) Somdatta Chatterjee et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

(2017) María-Natalia Lisa et al.   Nature Communications

Secondary Bacterial Infections Associated with Influenza Pandemics

(2017) Denise E. Morris et al.   Frontiers in Microbiology

B1-Metallo-β-Lactamases: Where Do We Stand?

(2016) Maria F. Mojica et al.   CURRENT DRUG TARGETS

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

(2016) Lisandro J González et al.   Nature Chemical Biology

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

(2016) Philip Hinchliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

(2015) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options

(2015) Ya-Ting Chang et al.   Frontiers in Microbiology

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

(2014) Timothy A. Blizzard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of bacterial outer membrane vesicle production by envelope structure and content

(2014) Carmen Schwechheimer et al.   BMC MICROBIOLOGY

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

The ABCD’s of β-lactamase nomenclature

(2013) Karen Bush   JOURNAL OF INFECTION AND CHEMOTHERAPY

Avibactam is a covalent, reversible, non- -lactam  -lactamase inhibitor

(2012) D. E. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Horizontal Transfer of the OXA-24 Carbapenemase Gene via Outer Membrane Vesicles: a New Mechanism of Dissemination of Carbapenem Resistance Genes in Acinetobacter baumannii

(2011) Carlos Rumbo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors

(2011) Ken Coleman   CURRENT OPINION IN MICROBIOLOGY

Characterization of a New Metallo- -Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

(2009) D. Yong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nutritional immunity beyond iron: a role for manganese and zinc

(2009) Thomas E Kehl-Fie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE