Spectroscopic and cloud point studies of the interaction and thermodynamics of ciprofloxacin hydrochloride plus surfactants mixture in different solvents: Effect of temperature and composition

Surfactant is one of the most important chemical entities in drug formulation which can bind with drug molecules. Herein, the binding interaction of ciprofloxacin hydrochloride (CFH) drug with two different surfactants (sodium dodecyl sulfate (SDS) and Triton X-100 (TX-100)) has been investigated through UV-Visible spectroscopic and cloud point measurement techniques at different conditions. The absorption spectrum of CFH was found to be dependent on presence of additives/temperature change. The binding constant (b) of CFH+SDS/CFH+TX-100 was found to be increased primarily, reached a maximum value and then decreased with the increase of temperature, except in water medium (pH=2.0) and 30% (v/v) methanol. The Kb values for CFH+SDS were found to be higher in the aqueous medium than almost all medium studied herein, while better binding was observed in the alcoholic medium in the case of the CFH+TX-100 system. The Gibbs free energy of binding (Delta Gb) for both CFH+SDS and CFH+TX-100 systems were attained negative in each case studied, inferring the spontaneous binding phenomenon. The cloud point (CP) value of CFH+TX-100 mixture was lessened in ZnSOO solution and the CP values exhibited a gradual reduction through the upsurge of electrolyte concentration. The positive values of the Gibbs free energy of clouding indicated the nonspontaneous clouding phenomena. To disclose the interaction between drug and surfactant, other thermodynamic parameters, e.g., enthalpy (Delta Hb) and entropy (Delta Sb), different transfer energies as well as entropy-enthalpy compensation parameters of binding/clouding were evaluated and clarified with proper explanation.

Automated summary

The binding interaction between ciprofloxacin hydrochloride (CFH) drug and two different surfactants (sodium dodecyl sulfate (SDS) and Triton X-100 (TX-100)) was studied through UV-Visible spectroscopic and cloud point measurement techniques. The binding constant (b) of CFH+SDS and CFH+TX-100 primarily increased, reached a maximum value, and then decreased with temperature, showing different patterns in different media. The cloud point (CP) value of CFH+TX-100 mixture decreased in ZnSO4 solution, with a gradual reduction through the increase of electrolyte concentration, indicating nonspontaneous clouding phenomena.