Article
Clinical Neurology
Dan He, Peilin Meng, Chun'e Li, Yumeng Jia, Yan Wen, Chuyu Pan, Zhen Zhang, Jingxi Zhang, Huijie Zhang, Yujing Chen, Yijing Zhao, Xiaoyue Qin, Qingqing Cai, Wenming Wei, Sirong Shi, Xiaoge Chu, Na Zhang, Feng Zhang
Summary: This study aimed to investigate the association and causal relationship between sleep and telomere length (TL). Using genome-wide association study (GWAS) datasets and mendelian randomization (MR) analysis, the study found no evidence for causal association between insomnia and TL in individuals of European ancestry, but identified a candidate gene associated with both insomnia and TL.
Article
Cardiac & Cardiovascular Systems
Rajat Deo, Ruth F. Dubin, Yue Ren, Ashwin C. Murthy, Jianqiao Wang, Haotian Zheng, Zihe Zheng, Harold Feldman, Haochang Shou, Josef Coresh, Morgan Grams, Aditya L. Surapaneni, Zeenat Bhat, Jordana B. Cohen, Mahboob Rahman, Jiang He, Santosh L. Saraf, Alan S. Go, Paul L. Kimmel, Ramachandran S. Vasan, Mark R. Segal, Hongzhe Li, Peter Ganz
Summary: Through large-scale proteomics discovery, this study aimed to create more accurate cardiovascular risk models for patients with chronic kidney disease (CKD). The proteomic risk model outperformed traditional clinical models in predicting cardiovascular risk and provided new biological insights for the development of cardiovascular risk management strategies in CKD patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Immunology
Feihong Ren, Qiubai Jin, Qi Jin, Yiyun Qian, Xuelei Ren, Tongtong Liu, Yongli Zhan
Summary: This study reveals the causal relationships between gut microbiota (GM) and chronic kidney disease (CKD), as well as GM and chronic systemic inflammation in CKD. It also expands the knowledge on specific causal gut microbiota. These causal gut microbiota may have the potential to serve as new biomarkers for targeted prevention of CKD and chronic systemic inflammation in CKD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Resham L. Gurung, Rajkumar Dorajoo, M. Yiamunaa, Ling Wang, Sylvia Liu, Jian-Jun Liu, Yi Ming Shao, Yuqing Chen, Xueling Sim, Keven Ang, Tavintharan Subramaniam, Wern Ee Tang, Chee Fang Sum, Su Chi Lim
Summary: The study suggests that genetically determined leukocyte telomere length is associated with an increased risk of chronic kidney disease in patients with type 2 diabetes. Further research is needed to clarify the causal role of telomere length in the progression of chronic kidney disease.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Immunology
Zhengtao Lv, Jiarui Cui, Jiaming Zhang
Summary: This study found a negative association between serum urate levels and telomere length, but no association with serum soluble inflammation markers. This suggests that telomere length may be a critical marker for urate-related organismal aging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Yudong Wei, Zengbin Li, Hao Lai, Pengyi Lu, Baoming Zhang, Lingqin Song, Lei Zhang, Mingwang Shen
Summary: This study aimed to explore the association between coffee consumption and telomere length. Observational analyses indicated that coffee intake, particularly instant coffee, was negatively correlated with telomere length. Mendelian randomization analyses supported the results of observational analyses. Therefore, coffee intake, especially instant coffee, was found to play an important role in shortening telomere length.
Article
Medicine, General & Internal
Han Zhang, Shuai Yuan, Yong Li, Doudou Li, Zengli Yu, Lidan Hu, Xue Li, Yuming Wang, Susanna C. Larsson
Summary: This study used Mendelian randomization to confirm a bidirectional causal association between atopic dermatitis and chronic kidney disease.
FRONTIERS IN MEDICINE
(2023)
Article
Genetics & Heredity
Wenqiang Zhang, Li Zhang, Luo M. Yang, Chenghan Xiao, Xueyao Wu, Peijing Yan, Huijie Cui, Chao Yang, Jingwei Zhu, Xuan Wu, Mingshuang R. Tang, Yutong Wang, Lin Chen, Yunjie A. Liu, Yanqiu M. Zou, Ling E. Zhang, Chunxia Yang, Yuqin Yao, Jiayuan Li, Zhenmi S. Liu, Ben Zhang, Xia Jiang
Summary: Epidemiological studies suggest an association between migraine and chronic kidney disease (CKD), but the genetic basis has not been investigated. We aimed to understand the phenotypic and genetic relationships between migraine, CKD, and kidney function to guide interventions for migraine patients.
Article
Immunology
Jiaxin Hu, Jukun Song, Zhu Chen, Jing Yang, Qianhui Shi, Fuqian Jin, Qiyuan Pang, Xingtao Chang, Yuan Tian, Yi Luo, Liming Chen
Summary: This study investigated the causal relationship between periodontitis and shortened telomere lengths (TL) using a two-sample Mendel randomized (MR) study. The results showed that a genetic prediction of short TL was causally associated with a higher risk of periodontitis, while periodontitis had no significant effect on TL. No pleiotropy was detected in sensitivity analysis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Shaojie Fu, Li Zhang, Fuzhe Ma, Shuai Xue, Tao Sun, Zhonggao Xu
Summary: The study used Mendelian randomization (MR) analysis to investigate the causal relationship between selenium levels and chronic kidney disease (CKD). The results showed that an increased level of selenium is a causative factor for kidney function impairment.
Review
Genetics & Heredity
Nannan Son, Yankun Cui, Wang Xi
Summary: TL shortening may promote skin aging development and reduce the risk of cutaneous melanoma and NMSCs.
FRONTIERS IN GENETICS
(2022)
Article
Urology & Nephrology
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study shows that higher education attainment is causally linked to a decreased risk of CKD development, suggesting a positive role of education attainment in preventing CKD.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Nutrition & Dietetics
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study indicates that higher relative protein intake is associated with a lower risk of chronic kidney disease, while increased relative fat intake is causally linked to kidney function impairment. Therefore, a desirable macronutrient composition, including high relative protein intake and low relative fat intake, may reduce the risk of chronic kidney disease in the general population.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Urology & Nephrology
Matthew B. Lanktree, Nicolas Perrot, Andrew Smyth, Michael Chong, Sukrit Narula, Meera Shanmuganathan, Zachary Kroezen, Philip Britz-Mckibbin, Mario Berger, Joan C. Krepinsky, Marie Pigeyre, Salim Yusuf, Guillaume Pare
Summary: Through proteome-wide Mendelian randomization, we identified 22 biomarkers that causally impact eGFR in either a beneficial or adverse manner. This study provides rationale for novel therapeutic targets for eGFR and emphasizes a role for extracellular proteins produced by tubular cells and fibroblasts in impacting eGFR.
KIDNEY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Ruoqing Chen, Yiqiang Zhan
Summary: This study investigated the potential association of telomere length with Parkinson's disease (PD) using Mendelian randomization, but did not find evidence to support a causal relationship between telomere length and PD.
NEUROBIOLOGY OF AGING
(2021)
Article
Gastroenterology & Hepatology
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The Mendelian randomization study found a causal relationship between NAFLD and reduced estimated glomerular filtration rate (eGFR), indicating that NAFLD may lead to kidney function impairment.
LIVER INTERNATIONAL
(2022)
Article
Cell Biology
Jangwook Lee, Yeonhee Lee, Kyu-Hong Kim, Dong-Ki Kim, Kwon-Wook Joo, Sung-Joon Shin, Yon-Su Kim, Seung-Hee Yang
Summary: This study found that chemokine (C-C motif) ligand 8 (CCL8) levels increased with the progression of chronic kidney disease (CKD). In vitro experiments showed that CCL8 was upregulated by fibrosis-inducing factor rTGF-beta, and blocking CCL8 could mitigate fibrosis and apoptosis. These findings suggest that the CCL8 pathway is associated with kidney fibrosis and blocking CCL8 could be a potential therapeutic strategy.
Article
Urology & Nephrology
Sehoon Park, Semin Cho, Soojin Lee, Yaerim Kim, Sanghyun Park, Hyeok Huh, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Kyungdo Han, Dong Ki Kim
Summary: Higher visit-to-visit blood pressure variability is significantly associated with a higher risk of dementia in chronic kidney disease patients, regardless of whether it is systolic or diastolic blood pressure variability.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Gyun Kim, Ju-Young Moon, Bermseok Oh, Ho Jun Chin, Dong Ki Kim, Jung Hwan Park, Sung Joon Shin, Bum Soon Choi, Chun Soo Lim, Sang Ho Lee
Summary: Age-related alterations in renal sodium handling may contribute to the elevation of blood pressure, as the pressure-natriuresis response is diminished in older individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Sehoon Park, Hajeong Lee, Jeongha Lee, Sangmoon Lee, Semin Cho, Hyeok Huh, Joo Young Kim, Minkyoung Park, Soojin Lee, Yaerim Kim, Murim Choi, Kwon Wook Joo, Yon Su Kim, Seung Hee Yang, Dong Ki Kim
Summary: Transcriptome profiling of tubulointerstitial tissue in glomerulonephritis identified DUSP1 as a potential biomarker for tubulointerstitial injury. Overexpression of DUSP1 alleviated inflammation, while its inhibition increased inflammatory markers. Combination of DUSP1 overexpression with low-concentration corticosteroid treatment showed more potent suppression of inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Transplantation
Ji Eun Kim, Jina Park, Sehoon Park, Mi-Yeon Yu, Seon Ha Baek, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Summary: The risk of de novo major adverse cardiovascular events (MACEs) in kidney transplant recipients (KTRs) is lower compared to dialysis patients and similar to the general population (GP). However, once such events occur, they increase the risk of mortality in KTRs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Geriatrics & Gerontology
Sehoon Park, Seong Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: Through genetic analysis, it has been found that smoking is causally related to various aging traits, and smoking is associated with poor aging and frailty. This finding is important for further understanding the impact of smoking on human health.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Critical Care Medicine
Seong Geun Kim, Donghwan Yun, Jinwoo Lee, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seung Seok Han
Summary: This study aimed to investigate the incidence of intradialytic hypotension (IDH) following the transition from continuous renal replacement therapy (CRRT) to intermittent hemodialysis (iHD), and its association with mortality risk. The results showed that IDH occurred in 36% of patients, with a higher mortality rate compared to those without IDH. Patients with IDH also experienced delayed weaning from renal replacement therapy. Therefore, IDH following the transition from CRRT to iHD is associated with increased mortality and delayed recovery.
ACUTE AND CRITICAL CARE
(2023)
Article
Endocrinology & Metabolism
Byungwook Kim, Dha Woon Im, Heejae Won, Jung Sunwoo, Seung Seok Han, Hajeong Lee, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Joo-Youn Cho, SeungHwan Lee, Jaeseong Oh, In-Jin Jang, Yong Chul Kim
Summary: The aim of this study was to investigate the potential effect of haemodialysis on the pharmacokinetic and pharmacodynamic characteristics of evogliptin, a dipeptidyl peptidase-4 inhibitor. The results showed that haemodialysis had no clinically significant effect on the pharmacokinetic and pharmacodynamic characteristics of evogliptin, indicating that dose adjustment is not necessary according to the haemodialysis status.
DIABETES OBESITY & METABOLISM
(2023)
Article
Urology & Nephrology
Seong Geun Kim, Chung Hee Han, Sung Bong Yu, Hyeseung Lee, Soie Kwon, Yerim Kim, Jeonghwan Lee, Dong Ki Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Byung Gun Kim, Jung Pyo Lee
Summary: AKI in COVID-19 patients is associated with poor prognosis. Characterization of AKI by timing and trajectory and early prediction of AKI progression is required for better preventive management and the prediction of patient outcomes.
Article
Nutrition & Dietetics
Jeong-Min Cho, Jung-Hun Koh, Seong-Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong-Chul Kim, Seung-Seok Han, Hajeong Lee, Jung-Pyo Lee, Kwon-Wook Joo, Chun-Soo Lim, Yon-Su Kim, Dong-Ki Kim, Sehoon Park
Summary: This study conducted a summary-level Mendelian randomization analysis to investigate the causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function. The results suggest a potential causal effect of chondroitin and glucosamine intake on a lower estimated glomerular filtration rate, while vitamin/mineral supplement intake may be associated with a higher eGFR.
Article
Medicine, General & Internal
Jin Ho Hwang, Sohee Oh, Ho Jun Chin, Sejoong Kim, Dong Ki Kim, Suhnggwon Kim, Jung Hwan Park, Sung Joon Shin, Sang-Ho Lee, Bum Soon Choi, Chun Soo Lim
Summary: This study compared various equations for estimating glomerular filtration rate with the results of 24-hour urine creatinine clearance. The IDMS-MDRD equation showed the best correlation with 24-hour urine creatinine clearance, while the CKD-EPI (2021) equation had the highest accuracy in CKD stage 1 and the KOR-IDMS-MDRD equation had the highest accuracy in CKD stages 2-3.
Article
Urology & Nephrology
Seong Geun Kim, Donghwan Yun, Jayoun Kim, Jinwoo Lee, Min Woo Kang, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Hoseok Koo, Yon Su Kim, Seung Seok Han
Summary: This study found that the occurrence of ventricular tachycardia (VT) during continuous renal replacement therapy (CRRT) is associated with increased patient mortality, especially sustained VT.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Urology & Nephrology
Jinwoo Lee, Jiyun Jung, Jangwook Lee, Jung Tak Park, Chan-Young Jung, Yong Chul Kim, Dong Ki Kim, Jung Pyo Lee, Sung Jun Shin, Jae Yoon Park
Summary: A modified Charlson Comorbidity Index (mCCI-CRRT) was developed to accurately assess the risk of mortality in severe acute kidney injury (AKI) patients requiring continuous renal replacement therapy (CRRT).
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Min Woo Kang, Navdeep Tangri, Soie Kwon, Lilin Li, Hyeseung Lee, Seung Seok Han, Jung Nam An, Jeonghwan Lee, Dong Ki Kim, Chun Soo Lim, Yon Su Kim, Sejoong Kim, Jung Pyo Lee
Summary: This study developed equations for predicting the mortality risk of patients on CRRT, which showed superior performance to previous scoring systems and can assist physicians in patient management.
