Article
Medicine, General & Internal
Man-Hung Eric Tang, Kim Lee Ng, Sofie Marie Edslev, Kirsten Ellegaard, Marc Stegger, Soren Alexandersen, Danish COVID Genom Consortium DCGC
Summary: A study found no significant statistical relationship between the levels of subgenomic RNAs in SARS-CoV-2 and host-related factors, suggesting that differences in target cell tropism, viral replication/transcription kinetics, or gene sequence features may contribute to the observed differences between lineages.
Review
Pharmacology & Pharmacy
Thales Kronenberger, Stefan A. Laufer, Thanigaimalai Pillaiyar
Summary: This article discusses the rationale for inhibitors targeting SARS-CoV-2 Mpro. Small molecules and peptidomimetic inhibitors are two types of inhibitors with different modes of action. Novel inhibitors discovered during the COVID-19 pandemic are highlighted, focusing on their binding modes and structures.
DRUG DISCOVERY TODAY
(2023)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Medicine, General & Internal
Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, Andrew C. Adams, Jacob Van Naarden, Kenneth L. Custer, Lei Shen, Michael Durante, Gerard Oakley, Andrew E. Schade, Janelle Sabo, Dipak R. Patel, Paul Klekotka, Daniel M. Skovronsky
Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, Bronwen E. Lambson, Tulio de Oliveira, Marion Vermeulen, Karin van der Berg, Theresa Rossouw, Michael Boswell, Veronica Ueckermann, Susan Meiring, Anne von Gottberg, Cheryl Cohen, Lynn Morris, Jinal N. Bhiman, Penny L. Moore
Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.
Article
Multidisciplinary Sciences
Emanuele Andreano, Ida Paciello, Silvia Marchese, Lorena Donnici, Giulio Pierleoni, Giulia Piccini, Noemi Manganaro, Elisa Pantano, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Piet Maes, Concetta De Santi, Claudia Sala, Emanuele Montomoli, Raffaele De Francesco, Rino Rappuoli
Summary: In this study, Andreano and Paciello et al. provide insights into the functional and genetic characteristics of the Omicron BA.1 and BA.2 cross-protective antibody response. Their findings reveal that SARS-CoV-2 vaccines can induce neutralizing antibodies that cross-neutralize the Omicron variants and SARS-CoV-1 virus.
NATURE COMMUNICATIONS
(2022)
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Chang-Sheng Xia, Minghua Zhan, Yudong Liu, Zhi-Hong Yue, Ying Song, Feifei Zhang, Hui Wang
Summary: This study assessed the levels of protective antibodies in SARS survivors with and without the COVID-19 vaccine, and found that SARS survivors have protective antibodies against SARS-CoV-2 even without vaccination, and generate a stronger antibody response after vaccination compared to controls.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Infectious Diseases
Dasha Majra, Jayme Benson, Jennifer Pitts, Justin Stebbing
Summary: Super spreader events (SSEs) can be categorized into 'societal' and 'isolated' events, with the former posing a greater threat and the latter being more easily quarantined.
JOURNAL OF INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Article
Biochemistry & Molecular Biology
Spyros Chalkias, Jordan L. Whatley, Frank Eder, Brandon Essink, Shishir Khetan, Paul Bradley, Adam Brosz, Nichole Mcghee, Joanne E. Tomassini, Xing Chen, Xiaoping Zhao, Andrea Sutherland, Xiaoying Shen, Bethany Girard, Darin K. Edwards, Jing Feng, Honghong Zhou, Stephen Walsh, David C. Montefiori, Lindsey R. Baden, Jacqueline M. Miller, Rituparna Das
Summary: This ongoing, open-label phase 2/3 trial compared the safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent mRNA1273.222 vaccine with the ancestral Wuhan-Hu-1 mRNA-1273 as booster doses. The bivalent vaccine showed superior neutralizing antibody responses against Omicron BA.4/BA.5 and noninferior responses against ancestral SARS-CoV-2 (D614G). The safety profile of the bivalent vaccine was similar to the ancestral vaccine.
Article
Health Care Sciences & Services
Anita D. Misra-Hebert, Christina Felix, Alex Milinovich, Michael W. Kattan, Marc A. Willner, Kevin Chagin, Janine Bauman, Aaron C. Hamilton, Jay Alberts
Summary: This study evaluated the predictive accuracy of a readmission risk score in various settings, including different hospitals, diagnosis categories, medical specialties, and patient race and ethnicity. The results showed that the risk score performed well across different conditions, even during the COVID-19 pandemic. Evaluating clinical decision-making tools post-implementation is crucial to ensure their continued relevance and improve their performance.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Hematology
Michael B. Rothberg, Aaron C. Hamilton, M. Todd Greene, Jacqueline Fox, Oleg Lisheba, Alex Milinovich, Thomas N. Gautier, Priscilla Kim, Scott Kaatz, Bo Hu
Summary: A new VTE risk assessment model has been developed and performs better than currently recommended models.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Surgery
Ali Aminian, Chao Tu, Alex Milinovich, Kathy E. Wolski, Michael W. Kattan, Steven E. Nissen
Summary: This cohort study showed that significant weight loss achieved through surgery was associated with improved outcomes in COVID-19 infection among patients with obesity. The findings suggest that obesity can be a modifiable risk factor for the severity of COVID-19 infection.
Article
Allergy
Joe G. Zein, Ronald Strauss, Amy H. Attaway, Bo Hu, Alex Milinovich, Nesreen Jawhari, Soulaima S. Chamat, Victor E. Ortega
Summary: This study investigates the associations between preexisting blood eosinophil counts, inhaled corticosteroids (ICS), and COVID-19 outcomes. The results suggest that preexisting eosinophilia and ICS treatment are associated with reduced hospitalization, admission to the intensive care unit (ICU), and mortality among patients with COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Medicine, General & Internal
Ali Aminian, Rickesha Wilson, Abbas Al-Kurd, Chao Tu, Alex Milinovich, Matthew Kroh, Raul J. Rosenthal, Stacy A. Brethauer, Philip R. Schauer, Michael W. Kattan, Justin C. Brown, Nathan A. Berger, Jame Abraham, Steven E. Nissen
Summary: In obese adults, bariatric surgery was associated with a significantly lower incidence of obesity-associated cancer and cancer-related mortality when compared to no surgery.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Anukriti Sharma, Anita D. D. Misra-Hebert, Arshiya Mariam, Alex Milinovich, Anthony Onuzuruike, Wilhemina Koomson, Michael W. W. Kattan, Kevin M. M. Pantalone, Daniel M. M. Rotroff
Summary: Reports indicate that COVID-19 may impact pancreatic function and increase T2D risk. A study comparing COVID-19(+) patients and matched control subjects found a statistically significant increase in HbA(1c) and T2D risk among COVID-19(+) patients. The study also suggests that COVID-19-attributed T2D risk may be due to increased recognition during COVID-19 management.
Article
Endocrinology & Metabolism
Kevin M. Pantalone, Xinge Ji, Sheldon X. Kong, Jay C. Elliott, Alex Milinovich, Anita D. Misra-Hebert, Ryan Farej, Rakesh Singh, Janine M. Bauman, Robert S. Zimmerman, Tushar J. Vachharajani, Jamie Partridge, Jennifer Cameron, Todd Williamson, Michael W. Kattan
Summary: This brief report uses EHR data to summarize unmet needs in patients with type 2 diabetes and chronic kidney disease and identifies opportunities to optimize management within this patient population.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Medicine, General & Internal
Dan-Yu Lin, Francois Abi Fadel, Shuaiqi Huang, Alex T. Milinovich, Gretchen L. Sacha, Patricia Bartley, Abhijit Duggal, Xiaofeng Wang
Summary: This study aimed to assess the association of nirmatrelvir or molnupiravir use with the risks of hospitalization and death among patients infected with new Omicron subvariants. It was a cohort study conducted at Cleveland Clinic from April 1, 2022, to February 20, 2023, with follow-up through 90 days after diagnosis. The findings suggest that both nirmatrelvir and molnupiravir are associated with reductions in mortality and hospitalization in patients infected with Omicron, regardless of various factors.
Meeting Abstract
Critical Care Medicine
C. Heinzinger, N. Thompson, A. Milinovich, N. Foldvary-Schaefer, D. Van Wagoner, M. Chung, R. Mehra
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Health Care Sciences & Services
Michael B. Rothberg, Aaron C. Hamilton, Alex Milinovich, Oleg Lisheba, Bo Hu
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Michael D. Faulx, Lu Wang, Megan Sheehan, Alex Milinovich, Nancy Foldvary-Schaefer, Reena Mehra
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Critical Care Medicine
Chao-ping Wu, Alex Milinovich, Rachael Shirley, Eduardo Mireles-Cabodevila, Abhijit Duggal, Hassan Khouli, Anirban Bhattacharyya
CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Allergy
Ronald Strauss, Joe Zein, Amy Attaway, Alex Milinovich, Nesreen Jawhari, Soulaima Chamat, Victor Ortega
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Correction
Health Care Sciences & Services
Glen B. Taksler, Jarrod E. Dalton, Adam T. Perzynski, Michael B. Rothberg, Alex Milinovich, Nikolas I. Krieger, Neal V. Dawson, Mary J. Roach, Michael D. Lewis, Douglas Einstadter
MEDICAL DECISION MAKING
(2022)