Article
Public, Environmental & Occupational Health
Zhongyu Jian, Menghua Wang, Xi Jin, Xin Wei
Summary: The study revealed that educational attainment is a predictor for susceptibility, hospitalization, and severity of COVID-19 disease, with higher educational attainment being associated with lower risk. The effects of educational attainment on COVID-19 outcomes were consistent in both single-variable and multivariable Mendelian randomization analyses.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Meng-Mei Zhong, Jia-Hao Xie, Yao Feng, Shao-Hui Zhang, Jiang-Nan Xia, Li Tan, Ning-Xin Chen, Xiao-Lin Su, Qian Zhang, Yun-Zhi Feng, Yue Guo
Summary: This study identified microbial taxa that are protective or risky for COVID-19, potentially serving as useful biomarkers for asymptomatic diagnosis and therapeutic targets for COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Li-Juan Qiu, Kang-Jia Yin, Gui-Xia Pan, Jing Ni, Bin Wang
Summary: Genetically predicted asthma was not associated with susceptibility to or severity of COVID-19 disease, indicating that asthma is unlikely to be a causal factor in the development of COVID-19.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Song Chen, Changhua Zheng, Tianlai Chen, Dianhua Huang, Yuancheng Pan, Shunyou Chen
Summary: The study found no correlation between plasma Vitamin C levels and COVID-19 susceptibility and severity, and further research is needed to explore the potential role in different ethnic groups.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yi Liang, Liang Liu, Bo Liang
Summary: This study found no direct causal relationship between COVID-19 and dyslipidemia, regardless of the severity of COVID-19 or the outcome of dyslipidemia. Previous studies have suggested that the clinical outcome of COVID-19 increasing the burden of dyslipidemia may be due to the exacerbation of pre-existing disease caused by COVID-19.
Article
Endocrinology & Metabolism
Hui-Qi Qu, Jingchun Qu, Joseph Glessner, Hakon Hakonarson
Summary: Obesity is a primary risk factor for COVID-19 hospitalization, while T2D is not.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Nutrition & Dietetics
Chunyu Li, Ruwei Ou, Qianqian Wei, Huifang Shang
Summary: Genetic predisposition to high carnitine levels may reduce susceptibility and severity of COVID-19, providing insights for novel therapeutic targets in future clinical trials.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Yi Wang, Hui Deng, Yihuai Pan, Lijian Jin, Rongdang Hu, Yongyong Lu, Wenhai Deng, Weijian Sun, Chengshui Chen, Xian Shen, Xiu-Feng Huang
Summary: The study suggests that periodontal disease is significantly associated with increased susceptibility to COVID-19 and severity of the disease in hospitalized patients. The findings emphasize the importance of oral health care for general wellbeing during and beyond the pandemic.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Zhihao Zhang, Tian Fang, Yonggang Lv
Summary: Using a bidirectional two-sample Mendelian randomization analysis, we found that COVID-19 might be a potential risk factor for hypothyroidism, but thyroid dysfunction did not affect the susceptibility and severity of COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Virology
Shizheng Qiu, Keyang Zheng, Yang Hu, Guiyou Liu
Summary: Observational studies have shown that vitamin D supplementation reduces the risk of COVID-19 infection. This study investigated the genetic correlation and causal relationship between genetically determined vitamin D and COVID-19, and identified overlapping susceptibility loci. The results indicated that genetically determined vitamin D is associated with COVID-19, and increased serum 25 hydroxyvitamin D concentration may benefit the prevention and treatment of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Nutrition & Dietetics
Ancha Baranova, Yuqing Song, Hongbao Cao, Weihua Yue, Fuquan Zhang
Summary: Tea intake has a negative causal effect on the risk of SARS-CoV-2 infection, but no causal effects were found on hospitalized COVID-19 or critical COVID-19. This study highlights the potential preventive effect of tea consumption on COVID-19 transmission.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Sai Zhang, Johnathan Cooper-Knock, Annika K. Weimer, Minyi Shi, Lina Kozhaya, Derya Unutmaz, Calum Harvey, Thomas H. Julian, Simone Furini, Elisa Frullanti, Francesca Fava, Alessandra Renieri, Peng Gao, Xiaotao Shen, Ilia Sarah Timpanaro, Kevin P. Kenna, J. Kenneth Baillie, Mark M. Davis, Philip S. Tsao, Michael P. Synder
Summary: This study utilizes machine learning to conduct multiomic analysis, identifying the genomic basis of severe COVID-19 in healthy adults. By linking genetic signals to cell-type-specific functions in human lungs, the study reveals over 1,000 risk genes across 19 cell types, with natural killer cells and T cells playing a pivotal role in disease severity.
Article
Medicine, General & Internal
Jie Zheng, Yuemiao Zhang, Huiling Zhao, Yi Liu, Denis Baird, Mohd Anisul Karim, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Benjamin Elsworth, Katherine Roberts, Hannah Compton, Felix Miller-Molloy, Xingzi Liu, Lin Wang, Hong Zhang, George Davey Smith, Tom R. Gaunt
Summary: The study used Mendelian randomization and colocalization approaches to analyze the causal effects of various transcripts and proteins on COVID-19 severity in European and African ancestries. Six protein targets, including OAS1, SERPINA1, ICAM1, ICAM5, FCRL3, and ENTPD5, were identified as potentially influencing COVID-19 severity. The study highlights the importance of considering ancestry-specific effects in understanding the impact of drug targets on COVID-19 severity across different populations.
Article
Cell Biology
Yiyin Zhang, Qijiang Mao, Yirun Li, Jiaxi Cheng, Qiming Xia, Guoqiao Chen, Peng Chen, Shengxi Jin, Duguang Li, Cheng Zhong, Jing Yang, Xiaoxiao Fan, Yuelong Liang, Hui Lin
Summary: This study investigated the causal association between predisposition to cancers and COVID-19 susceptibility and severity using Mendelian randomization. The findings showed that only the genetic predisposition to lung adenocarcinoma was causally associated with increased COVID-19 severity. The study also revealed broad mutation and differential expression of genes involved with COVID-19 in various cancers, potentially providing valuable insights for the development of new treatment strategies for patients with both cancer and COVID-19.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Satoshi Yoshiji, Daisuke Tanaka, Hiroto Minamino, Tianyuan Lu, Guillaume Butler-Laporte, Takaaki Murakami, Yoshihito Fujita, J. Brent Richards, Nobuya Inagaki
Summary: This study used Mendelian randomization to compare the independent causal relationships of body fat mass and fat-free mass with COVID-19 severity. The results showed that an increase in body fat mass was associated with severe COVID-19, while fat-free mass did not have an independent association with COVID-19. This suggests that body fat mass plays a mediating role in the biological pathways between COVID-19 and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)