Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 118, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2021.104452
Keywords
Antibacterial property; Aramid nanofibers; Hydrogel; Polyvinyl alcohol; Shape memory; Wound dressing
Funding
- Natural Science Foundation of China [81571829, 81701029]
- Open Project of State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences [LSL-1907]
- Clinical Research Center of Shanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University [2019YHJB09]
- Natural Science Foundation of Gansu Province [20JR10RA597, 20JR5RA264]
- Fundamental Research Funds for the Central Universities [lzujbkj-2019-ct07]
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A novel polyvinyl alcohol (PVA)/tannic acid (TA) hydrogel with aramid nanofibers (ANFs) as reinforcement was successfully fabricated, showing excellent mechanical properties and broad-spectrum antibacterial abilities against common bacteria. This hydrogel has potential applications as wound dressing due to its low cytotoxicity and shape memory properties.
The poor mechanical properties and the lack of antibacterial ability of hydrogels limit their applications as wound dressing. In this work, a novel and high strength polyvinyl alcohol (PVA)/tannic acid (TA) hydrogel with aramid nanofibers (ANFs) as the reinforcement was successfully fabricated. The surface composition and microstructure of the hydrogel were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The mechanical properties, water content and swelling behaviors, as well as the antibacterial abilities and biocompatibility of the prepared hydrogel were systematically analyzed as well. The results indicated that the prepared hydrogel showed excellent mechanical properties. The tensile strength and elongation of the prepared hydrogel can respectively reach 2.06 MPa and 950% owing to the formation of the multiple H bonds among PVA, ANFs and TA. What?s more, PVA/ ANFs/TA (PAT) hydrogel possessed shape memory and broad-spectrum antibacterial properties against S. aureus, E. coli and P. aeruginosa (100% antibacterial rate) at the concentration of 12 mg/mL. PAT hydrogels also had low cytotoxicity, affirming its potential application as wound dressing.
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