Article
Medicine, Research & Experimental
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser
Summary: The study found that orthostatic intolerance in ME/CFS patients is not caused by deconditioning as defined in cardiopulmonary exercise testing. An abnormally high decline in cerebral blood flow during orthostatic stress was present in all ME/CFS patients regardless of their %peak VO2 results on cardiopulmonary exercise testing.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Timothy Edwards, Emir Tas, Kenneth Leclerc, Elisabet Borsheim
Summary: Noninvasive cardiopulmonary exercise testing (CPET) is useful for analyzing pulmonary gas exchange and cardiovascular responses. This case report demonstrates how CPET can be used to identify potential cardiac pathologies in at-risk adolescents. An asymptomatic adolescent with abnormal CPET response and a family history of early-age CAD had elevated circulating hs-CRP levels, further supporting the significance of the abnormal CPET response. These findings highlight the importance of thorough clinical evaluation and monitoring in at-risk adolescents, especially when CPET abnormalities are combined with elevated hs-CRP.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Carl Gunnar Gottschalk, Ryan Whelan, Daniel Peterson, Avik Roy
Summary: Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a multisystem chronic illness characterized by severe muscle fatigue, pain, dizziness, and brain fog. Many patients with ME/CFS experience orthostatic intolerance (OI), which is characterized by frequent dizziness, light-headedness, and feeling faint while maintaining an upright posture. Despite intense investigation, the molecular mechanism of this debilitating condition is still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Lorenzo Nesti, Nicola Riccardo Pugliese, Lorenza Santoni, Silvia Armenia, Martina Chiriaco, Luca Sacchetta, Nicolo De Biase, Lavinia Del Punta, Stefano Masi, Domenico Trico, Andrea Natali
Summary: Effort intolerance is common in overweight/obese and/or type 2 diabetes (T2D) patients. T2D and body mass index (BMI) have independent effects on cardiopulmonary capacity. T2D is associated with lower VO2peak and subclinical cardiovascular dysfunctions.
DIABETES OBESITY & METABOLISM
(2023)
Review
Rehabilitation
Eva Pella, Marieta P. Theodorakopoulou, Afroditi K. Boutou, Maria-Eleni Alexandrou, Dimitra-Rafailia Bakaloudi, Despoina Sarridou, Aristi Boulmpou, Christodoulos Papadopoulos, Aikaterini Papagianni, Pantelis Sarafidis
Summary: This systematic review and meta-analysis compares individuals with chronic kidney disease (CKD) to those without CKD using cardiopulmonary exercise testing (CPET). The study found that CKD patients have lower cardiopulmonary reserve compared to controls and perform better than controls with heart failure without CKD. The findings suggest the need for widespread application of rehabilitation programs for individuals with CKD.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Erik H. Van Iterson, Leslie Cho, Adriano Tonelli, J. Emanuel Finet, Luke J. Laffin
Summary: In patients with HFrEF, demonstrating a restrictive pattern on spirometry yields the severest mortality risk associated with (V) over dotO(2peak). Using spirometry to screen patients with HFrEF for ventilatory defects has a potential role in improving risk stratification based on (V) over dotO(2peak).
Article
Physiology
Nina K. Vollestad, Anne Marit Mengshoel
Summary: The study suggests that patients with ME/CFS report a wide range of experiences related to PEM, which can be triggered by physical or mental exertion and may have an immediate or delayed onset with varying duration. Experimental exercise tests show that symptom exacerbation has a quicker onset but varies in duration. Repeated exercise over several days may lead to altered muscular metabolism and autonomic nervous responses.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lanting Zhao, Yuanwei Liu, Siyuan Li, Ying Xie, Yajun Xue, Yifang Yuan, Rong He, Fei She, Tingting Lv, Ping Zhang
Summary: This study evaluated the cardiopulmonary function and exercise capacity of acute myocardial infarction (AMI) patients at different times using low-level cardiopulmonary exercise test (CPET). The results showed that it was safe and efficient to perform low-level CPET in stable AMI patients 3 days after onset. Complete revascularization and normal left ventricular ejection fraction (LVEF) were beneficial for exercise testing in AMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Sport Sciences
Viviana Maestrini, Marco Penza, Domenico Filomena, Lucia Ilaria Birtolo, Sara Monosilio, Erika Lemme, Maria Rosaria Squeo, Ruggiero Mango, Giuseppe Di Gioia, Andrea Serdoz, Roberto Fiore, Francesco Fedele, Antonio Pelliccia, Barbara Di Giacinto
Summary: This study evaluated the cardiac involvement in competitive athletes after COVID-19 and found a low prevalence of myocarditis but a notable occurrence of uncommon premature ventricular contractions (PVCs). Some athletes were temporarily restricted from sports participation.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Nutrition & Dietetics
Pierre-Edouard Grillet, Stephanie Badiou, Karen Lambert, Thibault Sutra, Maelle Plawecki, Eric Raynaud de Mauverger, Jean-Frederic Brun, Jacques Mercier, Fares Gouzi, Jean-Paul Cristol
Summary: Screening for skeletal muscle diseases is a challenging task, as exercise tests or plasmatic tests alone have limited effectiveness. This study found that adjusting the levels of lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate during a cardiopulmonary exercise test can serve as valid biomarkers for screening muscle oxidative metabolism impairment. These markers show similar abnormalities in muscle disease patients and subjects with muscle complaints and demonstrate impaired adaptations.
Article
Pediatrics
Adam W. Powell, Wayne A. Mays, Samuel G. Wittekind, Clifford Chin, Sandra K. Knecht, Sean M. Lang, Alexander R. Opotowsky
Summary: This study investigated the impact of sport and school restrictions during the early stages of the COVID-19 pandemic on exercise performance and body composition in children and young adults with heart disease. The results showed that the pandemic and related lifestyle changes did not have substantial negative effects on aerobic fitness or body composition in this population.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pharmacology & Pharmacy
Peter L. Toogood, Daniel J. Clauw, Sameer Phadke, David Hoffman
Summary: ME/CFS is a chronic debilitating disease characterized by severe fatigue, pain, sleep disruption, and cognitive dysfunction. Current treatments focus on symptom management and addressing psychological sequelae, with ongoing efforts towards identifying effective therapies and understanding the mechanistic basis of the disease.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Geoffrey E. Moore, Betsy A. Keller, Jared Stevens, Xiangling Mao, Staci R. Stevens, John K. Chia, Susan M. Levine, Carl J. Franconi, Maureen R. Hanson
Summary: This study aimed to quantify the duration of post-exertional malaise (PEM) symptoms. Using the Symptom Severity Scale (SSS), the severity and duration of PEM symptoms in ME/CFS patients and healthy controls were assessed. The results showed a significantly prolonged recovery time in ME/CFS patients, with an average of about two weeks, compared to only two days in the control group. These data provide valuable insights for understanding and managing exercise-induced symptoms in ME/CFS patients.
MEDICINA-LITHUANIA
(2023)
Article
Physiology
Kathrin Rottermann, Annika Weigelt, Tim Staebler, Benedikt Ehrlich, Sven Dittrich, Isabelle Schoeffl
Summary: This study compares the results of a mobile device-based outdoor running test with a treadmill test. The results show that the outdoor test is significantly shorter in duration and yields higher values for almost all cardiopulmonary variables. Testing very young children with a mobile device is a new alternative that allows for individualized and standardized exercise testing.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katherine A. Glass, Arnaud Germain, Yuhsin V. Huang, Maureen R. Hanson
Summary: The aim of this pilot study was to investigate the changes in urine metabolome between ME/CFS patients and healthy subjects following exertion. The results showed that there were no significant changes in urine metabolome of ME/CFS patients during recovery, while significant changes were observed in healthy subjects, suggesting a lack of adaptation to severe stress in ME/CFS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)