Article
Cardiac & Cardiovascular Systems
Haseeb Rahman, Cian M. Scannell, Ozan M. Demir, Matthew Ryan, Hannah McConkey, Howard Ellis, Pier Giorgio Masci, Divaka Perera, Amedeo Chiribiri
Summary: This study demonstrated that high-resolution cardiac magnetic resonance (CMR) has good accuracy in detecting coronary microvascular dysfunction (CMD) when analyzed quantitatively. Quantitative perfusion CMR plays an increasingly important role in the management of patients with angina and nonobstructive coronary artery disease (NOCAD).
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Ashkan Eftekhari, Tim P. van de Hoef, Masahiro Hoshino, Joo Myung Lee, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Mohamed A. Effat, Koen Marques, Joon-Hyung Doh, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Tadashi Murai, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Paul Knaapen, Niels van Royen, Javier Escaned, Bon Kwon Koo, Steven A. J. Chamuleau, Tsunekazu Kakuta, Jan J. Piek, Evald Hoj Christiansen
Summary: This study investigated the association between changes in microvascular resistance (MR) and target vessel failure (TVF) in patients undergoing percutaneous coronary intervention (PCI). The results showed that increased MR post-PCI was associated with lesions of less severe hemodynamic influence at baseline and higher rates of TVF at follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Saveria Femmino, Fabrizio D'Ascenzo, Francesco Ravera, Stefano Comita, Filippo Angelini, Andrea Caccioppo, Luca Franchin, Alberto Grosso, Cecilia Thairi, Emilio Venturelli, Claudia Cavallari, Claudia Penna, Gaetano Maria De Ferrari, Giovanni Camussi, Pasquale Pagliaro, Maria Felice Brizzi
Summary: In this study, it was found that extracellular vesicles (EVs) recovered from ACS patients after PCI were not cardio-protective, regardless of whether they underwent remote ischemic pre-conditioning or not.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Retesh Bajaj, Ramya Parasa, Anantharaman Ramasamy, Nicole Makariou, Nicolas Foin, Francesco Prati, Alexandra Lansky, Anthony Mathur, Andreas Baumbach, Christos V. Bourantas
Summary: Advances in image processing and computer hardware have led to the development of user-friendly software for real-time operation in the catheterization laboratory, enabling more reliable evaluation of vessel geometry and lesion dimensions for PCI.
AMERICAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Taishi Yonetsu, Kodai Sayama, Kazuki Matsuda, Hiroki Ueno, Tatsuhiro Nagamine, Toru Misawa, Masahiro Hada, Masahiro Hoshino, Tomoyo Sugiyama, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study investigated the determinants and prognostic implications of changes in coronary flow capacity (CFC) following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The results showed that changes in CFC were associated with the risk of incident target vessel failure (TVF) and were largely predicted by the pre-PCI CFC status.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kai Nogami, Masahiro Hoshino, Yoshihisa Kanaji, Tomoyo Sugiyama, Toru Misawa, Masahiro Hada, Masao Yamaguchi, Tatsuhiro Nagamine, Yun Teng, Hiroki Ueno, Kazuki Matsuda, Kodai Sayama, Tsunekazu Kakuta
Summary: This study assessed the prevalence and prognostic significance of unrecognized myocardial infarction (UMI) before elective percutaneous coronary intervention (PCI) using delayed-enhancement cardiac magnetic resonance (DE-CMR). The results showed that UMI was significantly associated with sex, diabetes mellitus, left ventricular ejection fraction, SYNTAX score, and fractional flow reserve in the target vessels. UMI was found to be an independent predictor of major adverse cardiac events (MACE) and was associated with a higher risk of MACE after successful PCI.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Gaurav Chandola, Jun-Mei Zhang, Ru-San Tan, Ping Chai, Lynette Teo, John C. Allen, Ris Low, Weimin Huang, Shuang Leng, Jiang Ming Fam, Chee Yang Chin, Ghassan S. Kassab, Adrian Fatt Hoe Low, Swee Yaw Tan, Terrance Chua, Soo Teik Lim, Liang Zhong
Summary: The study assessed the feasibility and accuracy of a non-invasive FFR calculation based on CTCA for predicting coronary hemodynamics before and after stenting, finding a good correlation and agreement with invasive FFR, especially in predicting the hemodynamic effects post-stenting, indicating its potential as a useful tool in PCI planning.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Rasha K. Al-Lamee, Christopher A. Rajkumar, Sashiananthan Ganesananthan, Allen Jeremias
Summary: Invasive coronary physiology has become established as an important component in guidelines for managing stable coronary artery disease, improving clinical outcomes and cost efficiency. Despite recent doubts from randomized controlled trials, it remains crucial for selecting patients for coronary revascularization.
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The study aimed to evaluate the feasibility and efficacy of a post-PCI FFR-guided optimization strategy compared to standard coronary angiography in achieving final post-PCI FFR values >= 0.90. While the FFR-guided optimization strategy did not significantly increase the proportion of patients with final FFR >= 0.90, it did significantly reduce the proportion of patients with final FFR <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Seung Hun Lee, Doosup Shin, Joo Myung Lee, Tim P. van de Hoef, David Hong, Ki Hong Choi, Doyeon Hwang, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Hernan Mejia-Renteria, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Hyun Kuk Kim, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Bon Kwon Koo, Tsunekazu Kakuta, Javier Escaned, Jan J. Piek
Summary: In stable patients with nonobstructive coronary stenoses, a diagnosis of INOCA based only on abnormal NIT did not identify patients with higher risk of long-term cardiovascular events. Incorporating intracoronary physiologic assessment to NIT information in patients with nonobstructive disease allowed identification of patient subgroups with up to 4-fold difference in long-term cardiovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Junji Matsuda, Rikuta Hamaya, Masahiro Hoshino, Yoshihisa Kanaji, Tomoyo Sugiyama, Tadashi Murai, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study investigated the relationships between physiological indices and increased coronary flow during PCI using a novel index of anticipated maximum flow. The study found that pre-PCI AMF provided incremental ability to predict increased coronary flow after PCI and impacted the discordance between FFR improvement and increased coronary flow. This suggests the potential usefulness of AMF in predicting outcomes of PCI procedures.
JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ignacio Hernandez, Laura Tesoro, Rafael Ramirez-Carracedo, Javier Diez-Mata, Sandra Sanchez, Marta Saura, Jose Luis Zamorano, Carlos Zaragoza, Laura Botana
Summary: Our study demonstrated that Ivabradine can reduce cardiac necrosis by decreasing EMMPRIN/CyPA-mediated cardiac inflammation. This may be achieved by affecting the secretion of CyPA and its binding to EMMPRIN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Tara Neleman, Alessandra Scoccia, Kaneshka Masdjedi, Mariusz Tomaniak, Jurgen M. R. Ligthart, Karen T. Witberg, Alise Vermaire, Quinten Wolff, Leon Visser, Paul Cummins, Isabella Kardys, Jeroen Wilschut, Roberto Diletti, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen
Summary: Lower post-PCI vFFR values are significantly associated with an increased risk of TVF and TVR at 5 years follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Peripheral Vascular Disease
Nicholas Chiu, Leonard Chiu, Rahul Aggarwal, Inbar Raber, Deepak L. Bhatt, Kenneth J. Mukamal
Summary: Appropriate treatment intensification for older adults with hypertension in the United States was suboptimal over the past decade, with a decrease in the proportion of visits where intensification occurred.
Article
Cardiac & Cardiovascular Systems
Kim A. Connelly, C. David Mazer, Pankaj Puar, Hwee Teoh, Chao-Hung Wang, Tamique Mason, Farhad Akhavein, Ching-Wen Chang, Min-Hui Liu, Ning- Yang, Wei-Siang Chen, Yu-Hsiang Juan, Erika Opingari, Yaseen Salyani, William Barbour, Aryan Pasricha, Shamon Ahmed, Andrew Kosmopoulos, Raj Verma, Michael Moroney, Ehab Bakbak, Aishwarya Krishnaraj, Deepak L. Bhatt, Javed Butler, Mikhail N. Kosiborod, Carolyn S. P. Lam, David A. Hess, Otavio Rizzi Coelho-Filho, Myriam Lafreniere-Roula, Kevin E. Thorpe, Adrian Quan, Lawrence A. Leiter, Andrew T. Yan, Subodh Verma
Summary: This study aimed to evaluate the effect of sodium-glucose cotransporter 2 inhibition with empagliflozin on left ventricular mass in individuals without diabetes or significant heart failure. The results showed that after 6 months of treatment with empagliflozin, there was no significant reduction in left ventricular mass index. The findings suggest that empagliflozin may not have meaningful benefits on cardiac remodeling in this population.
Article
Cardiac & Cardiovascular Systems
Senthil Selvaraj, Stephen J. Greene, Iyanuoluwa Ayodele, Brooke Alhanti, Larry A. Allen, Sabra C. Lewsey, Srinath Adusumalli, Nosheen Reza, Adrian F. Hernandez, Clyde W. Yancy, Anupam B. Jena, Gregg C. Fonarow, Deepak L. Bhatt
Summary: This study investigated the impact of patient age on quality of care in heart failure and found that discharge date relative to 80th birthday did not affect healthcare quality or outcomes.
CIRCULATION-HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Madhab Ray, Santanu Guha, Bipasha Ray, Varun Saxena, Badri Viswanathan, Meghna Ray, Vivaan Desai, Nina Velu, Umika Paul, Ishi Singh, Srijani Ray, Dhriti Mandal, Bedatrayee Roy, Srijon Mandal, Prakash C. Hazra, Chaya D. Ray, Sudipta Chaudhuri, Avik Karak, Basabendra Chowdhury, Deepak L. Bhatt, Robert J. Goldberg, Harry P. Selker
Review
Pharmacology & Pharmacy
Luis Ortega-Paz, Salvatore Giordano, Francesco Franchi, Fabiana Rollini, Charles V. Pollack Jr, Deepak L. Bhatt, Dominick J. Angiolillo
Summary: Antiplatelet agents are commonly used in cardiovascular medicine but come with the risk of bleeding. Percutaneous coronary intervention patients, in particular, face challenges in managing antiplatelet drugs due to the need for surgical procedures and the lack of approved reversal agents. Bentracimab, a monoclonal antibody, has shown potential as a reversal agent for ticagrelor.
CLINICAL PHARMACOKINETICS
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas H. Schindler, William F. Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D. Ruddy, Krishna K. Patel, Deepak L. Bhatt, Timothy M. Bateman, Henry Gewirtz, Jamshid Shirani, Juhani Knuuti, Robert J. Gropler, Panithaya Chareonthaitawee, Riemer H. J. A. Slart, Stephan Windecker, Philipp A. Kaufmann, Maria R. Abraham, Viviany R. Taqueti, Thomas J. Ford, Paolo G. Camici, Heinrich R. Schelbert, Vasken Dilsizian
Summary: Diagnosing angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels is challenging. Invasive coronary angiography can identify nonobstructive coronary artery disease, but coronary microvascular dysfunction may actually be the cause of symptoms. Positron emission tomography (PET) allows noninvasive detection and delineation of coronary microvascular dysfunction by quantifying myocardial blood flow at rest and during vasodilation. Individualized or intensified medical therapies may improve symptoms, quality of life, and outcomes. Standardized diagnosis and reporting criteria for ischemic symptoms caused by coronary microvascular dysfunction are crucial for treatment decisions. A consensus document proposes standardized diagnosis, nomenclature, and reporting criteria for coronary microvascular dysfunction. It aims to provide an overview of its pathophysiology, assessment, and classification, which are essential for diagnosis, patient care, and clinical trials. (J Am Coll Cardiol Img 2023;16:536-548) (c) 2023 by the American College of Cardiology Foundation.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Brian Olshansky, Deepak L. L. Bhatt, Michael Miller, Ph. Gabriel Steg, Eliot A. A. Brinton, Terry A. A. Jacobson, Steven B. B. Ketchum, Ralph T. T. Doyle Jr, Rebecca A. A. Juliano, Lixia Jiao, Peter R. R. Kowey, James A. A. Reiffel, Jean-Claude Tardif, Christie M. M. Ballantyne, Mina K. K. Chung
Summary: In the REDUCE-IT study, icosapent ethyl (IPE) reduced cardiovascular events but was associated with increased atrial fibrillation/atrial flutter (AF) hospitalization. The study analyzed the relationships between IPE and outcomes in patients with or without prior AF and with or without in-study AF hospitalization. Overall, in-study AF hospitalization rates were higher in patients with prior AF, especially in those randomized to IPE. Serious bleeding rates also trended higher in these patients. However, patients with prior AF or in-study AF hospitalization showed consistent risk reductions in cardiovascular events with IPE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Correction
Medicine, General & Internal
Andrew M. Freeman, Subha V. Raman, Monica Aggarwal, David J. Maron, Deepak L. Bhatt, Purvi Parwani, John Osborne, James P. Earls, James K. Min, Jeroen J. Bax, Michael D. Shapiro
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
John Gregson, Gregg W. Stone, Deepak L. Bhatt, Milton Packer, Stefan D. Anker, Cordula Zeller, Bjorn Redfors, Stuart J. Pocock
Summary: Many randomized trials in cardiovascular disease focus on time-to-first event as the primary outcome, but repeat nonfatal events often occur during patient follow-up. This article explores the value of including repeat events in the analysis, compares different statistical methods for analyzing repeat events, and provides recommendations for future trials based on their performance in cardiovascular trials and heart failure trials.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Subodh Verma, Deepak L. Bhatt, Gilbert H. L. Tang
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Madhab Ray, Santanu Guha, Ranga Raj Dhungana, Avik Karak, Basabendra Choudhury, Bipasha Ray, Haroon Zubair, Meghna Ray, Srijan Sengupta, Deepak L. Bhatt, Robert J. Goldberg, Harry P. Selker
Summary: A questionnaire-based risk-scoring system was developed to identify children at risk for rheumatic heart disease (RHD) in rural India. The predictive model was validated in Nepal, which has a similar demographic profile to rural India.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Grace Erne, Pennelope K. Blakely, Elizabeth Anderson, Namratha Nelapudi, Medha Tripathi, Anis Ismail, Annika Tekumulla, Kingsley Amadi, Tonimarie Catalan, Alexi Vasbinder, Brayden Bitterman, Jiazi Chen, Caroline Tilley, Noor Sulaiman, Feriel Presswalla, Ian Pizzo, Nathan Meyette, Philippe Gabriel Steg, Michael Szarek, Franklin Sun, Michael Davies, Deepak L. Bhatt, Bertram Pitt, Salim Hayek
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Makoto Hibino, Michael E. Halkos, Douglas A. Murphy, Nitish Dhingra, Raj Verma, Bobby Yanagawa, Deepak L. Bhatt, Subodh Verma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anders G. Holst, Janos Tomcsanyi, Birgitte Vestbjerg, Morten Grunnet, Ulrik S. Sorensen, Jonas G. Diness, Bo H. Bentzen, Nils Edvardsson, Stefan H. Hohnloser, Deepak L. Bhatt, Paul Dorian
Summary: AP30663, an inhibitor of the K(Ca)2 channel, demonstrated efficacy in cardioversion from AF to sinus rhythm in patients with recent-onset AF episodes.
Review
Cardiac & Cardiovascular Systems
Ana Devesa, Borja Ibanez, Waqas A. Malick, Elizabeth O. Tinuoye, Jessica Bustamante, Carlos Peyra, Robert S. Rosenson, Deepak L. Bhatt, Gregg W. Stone, Valentin Fuster
Summary: There is evidence that the atherosclerotic process leading to cardiovascular disease (CVD) starts at a young age. Even at normal levels, exposure to low-density lipoprotein-cholesterol and other cardiovascular risk factors increases the prevalence of early atherosclerosis and the risk of future cardiovascular events. The PRECAD trial aims to evaluate the potential benefits of aggressively controlling cardiovascular risk factors in otherwise healthy young adults (<40 years) to prevent the onset or progression of atherosclerosis. The primary endpoint is the change in total atherosclerosis burden.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
