Article
Cell Biology
Satoshi Kawaguchi, Bruno Moukette, Marisa N. Sepulveda, Taiki Hayasaka, Tatsuya Aonuma, Angela K. Haskell, Jessica Mah, Suthat Liangpunsakul, Yaoliang Tang, Simon J. Conway, Il-man Kim
Summary: miR-150 is downregulated during heart failure and correlates with patient outcomes. It protects against myocardial infarction by reducing cardiomyocyte apoptosis and targets small proline-rich protein 1a. Knockdown of SPrr1a improves cardiac dysfunction and fibrosis post-MI.
CELL DEATH & DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Weiwei Lu, Zhaojie Meng, Rebecca Hernandez, Changcheng Zhou
Summary: The study demonstrates the crucial role of IKK-beta in regulating fibroblast functions and cardiac remodeling, showing that fibroblast-specific IKK-beta deficiency can protect mice from hypertension-induced adverse cardiac remodeling, including hypertrophy, fibrosis, and macrophage infiltration. Ablation of fibroblast IKK-beta inhibits proinflammatory and profibrogenic responses, leading to improved cardiac remodeling and function.
Article
Multidisciplinary Sciences
Maria Carmen Asensio-Lopez, Yassine Sassi, Fernando Soler, Maria Josefa Fernandez del Palacio, Domingo Pascual-Figal, Antonio Lax
Summary: Elevation of miR-199a-5p post-myocardial infarction leads to pathological cardiac hypertrophy by increasing soluble sST2 levels. AntimiR199a therapy regulates Sirt1 and inactivates P300 protein to inhibit Yy1, reducing sST2 release by cardiomyocytes after myocardial infarction. Pharmacological inhibition of miR-199a rescues cardiac hypertrophy and heart failure in mice, offering a potential therapeutic approach for cardiac failure.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Menglong Wang, Mengmeng Zhao, Junping Yu, Yao Xu, Jishou Zhang, Jianfang Liu, Zihui Zheng, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Cheng Wei, Jun Wan
Summary: This study investigated the effects of the selective NLRP3 inhibitor MCC950 on heart failure (HF) induced by pressure overload in obese mice and its metabolic mechanism. The results showed that MCC950 improved cardiac hypertrophy, fibrosis, and inflammation in obese mice. It also promoted M2 macrophage infiltration and regulated fatty acid and glucose uptake and utilization. Additionally, MCC950 affected the phosphorylation of AKT and AMPK in obese mice with HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Eva M. Calderon-Sanchez, Debora Falcon, Marta Martin-Bornez, Antonio Ordonez, Tarik Smani
Summary: Despite advancements in myocardial protection strategies, ischemic heart diseases and heart failure remain leading causes of global mortality. Reperfusion/revascularization can cause additional damage to myocardial tissue, while studies on urocortin indicate promising potential for developing new cardioprotective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Robert A. Eder, Maaike van den Boomen, Salva R. Yurista, Yaiel G. Rodriguez-Aviles, Mohammad Rashedul Islam, Yin-Ching Iris Chen, Lena Trager, Jaume Coll-Font, Leo Cheng, Haobo Li, Anthony Rosenzweig, Christiane D. Wrann, Christopher T. Nguyen
Summary: This study reveals that exercise training induces regional remodeling of the heart's microstructural tissue, and the expression of the CITED4 gene is necessary for this process.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka A. Gorska, Clara Sandmann, Eva Riechert, Christoph Hofmann, Ellen Malovrh, Eshita Varma, Vivien Kmietczyk, Julie Oelschlaeger, Lonny Juergensen, Verena Kamuf-Schenk, Claudia Stroh, Jennifer Furkel, Mathias H. Konstandin, Carsten Sticht, Etienne Boileau, Christoph Dieterich, Norbert Frey, Hugo A. Katus, Shirin Doroudgar, Mirko Voelkers
Summary: The study reveals the role of mTOR in pathological remodeling of the heart, showing that it protects cardiomyocytes by controlling the translation of specific genes, with Cand2 being a mTOR-regulated protective gene.
Article
Medicine, Research & Experimental
Franziska Werner, Estefania Prentki Santos, Konstanze Michel, Hanna Schrader, Katharina Voelker, Tamara Potapenko, Lisa Krebes, Marco Abesser, Dorothe Moellmann, Martin Schlattjan, Hannes Schmidt, Boris V. Skryabin, Katarina Spiranec Spes, Kai Schuh, Christopher P. Denton, Hideo A. Baba, Michaela Kuhn
Summary: Excessive activation of cardiac fibroblasts causes cardiac fibrosis, stiffness, and failure. This study examined the role of endogenous C-type natriuretic peptide (CNP) in fibroblast-specific guanylyl cyclase-B (GC-B) deletion mice. The results showed that CNP signaling has antifibrotic and antihypertrophic effects, and that the CNP/GC-B/cGMP pathway may be a target for therapies combating pathological cardiac remodeling.
Article
Cardiac & Cardiovascular Systems
Jamie Francisco, Jin Guan, Yu Zhang, Yasuki Nakada, Satvik Mareedu, Eunah Sung, Che-Ming Hu, Shinichi Oka, Peiyong Zhai, Junichi Sadoshima, Dominic P. Del Re
Summary: Inflammation is a crucial factor in cardiovascular disease, and Yes-associated protein (YAP) has been found to play a key role in modulating inflammation in ischemic injury. This study investigated the role of YAP in non-ischemic cardiac inflammation. The results showed that YAP activation in myeloid cells contributes to cardiac inflammation and fibrosis during pressure overload stress. Inhibition of YAP may be a potential therapeutic target for non-ischemic heart disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elise L. Kessler, Jiong-Wei Wang, Bart Kok, Maike A. Brans, Angelique Nederlof, Leonie van Stuijvenberg, Chenyuan Huang, Aryan Vink, Fatih Arslan, Igor R. Efimov, Carolyn S. P. Lam, Marc A. Vos, Dominique P. de Kleijn, Magda S. C. Fontes, Toon A. B. van Veen
Summary: Deficiency of TLR2 alleviates adverse cardiac remodeling caused by chronic pressure overload, with TLR2 and TLR4 both contributing to this process. The findings provide insights into potential therapeutic targets for preventing or intervening in cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Alan J. Mouton, Elizabeth R. Flynn, Sydney P. Moak, Xuan Li, Alexandre A. da Silva, Zhen Wang, Jussara M. do Carmo, Michael E. Hall, John E. Hall
Summary: Obesity alone does not cause cardiac injury or exacerbate hypertension-induced cardiac dysfunction. After MI, obese-normotensive mice had lower survival rates compared with chow-fed mice, and this was further decreased by hypertension. Surviving obese-normotensive mice displayed improved post-MI cardiac function and metabolism, while these favorable changes were attenuated by hypertension when it accompanied obesity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Luo, Stephen D. D. Farris, Deri Helterline, April Stempien-Otero
Summary: Cardiomyocytes increase DNA content in response to stress in humans, but this study found that DNA content decreases in unloaded hearts. Changes in DNA content were independent of cell proliferation. The study used a novel imaging flow cytometry methodology to compare human subjects with LVAD implantation or primary transplantation. Results showed that cardiomyocyte size decreased and DNA content per nucleus significantly decreased in unloaded hearts, while cell-cycle markers were not increased.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Leo F. Buckley, Brian L. Claggett, Kunihiro Matsushita, Gearoid M. McMahon, Hicham Skali, Josef Coresh, Aaron R. Folsom, Suma H. Konety, Lynne E. Wagenknecht, Thomas H. Mosley, Amil M. Shah
Summary: This study aimed to investigate the associations between kidney dysfunction and damage and heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), as well as adverse cardiac remodeling in late-life. The results showed that mild to moderate kidney dysfunction and damage were associated with incident HF and adverse cardiac remodeling in late-life.
JACC-HEART FAILURE
(2023)
Review
Medicine, General & Internal
C. A. Bonfiglio, C. Weber, D. Atzler, E. Lutgens
Summary: Current therapies for cardiovascular disease primarily focus on lipid lowering and face residual risk. Inflammation, along with lipids, plays a significant role in atherosclerosis. Clinical trials targeting the interleukin-1 beta-inflammasome pathway have successfully reduced cardiovascular events but not overall CVD mortality. Novel and improved immunotherapeutics for CVD are eagerly anticipated.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Virginia Egea, Remco Theodorus Adrianus Megens, Donato Santovito, Sarawuth Wantha, Richard Brandl, Wolfgang Siess, Sajjad Khani, Oliver Soehnlein, Alexander Bartelt, Christian Weber, Christian Ries
Summary: let-7f promotes hMSC tropism towards atheromas through the LL-37/FPR2 axis and demonstrates that hMSCs develop a potentially athero-protective signature upon contact with the human plaque environment.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Schueler, Christopher T. Bowles, Rabea Hinkel, Robert Wohlfarth, Michael R. Schmid, Stephen Wildhirt, Ulrich Stock
Summary: This study investigated the function and safety of a novel mechanical circulatory support device called reBEAT, which provides bloodless, pulsatile, biventricular support. The device was successfully implanted in animals, and real-time mechanical support synchronization with each cardiac cycle was achieved through continuous epicardial electrocardiogram signal analysis. Acute experiments showed progressive improvements in cardiac hemodynamic parameters, and long-term survival experiments demonstrated safe device integration and stable electrocardiogram signal detection. This study suggests that reBEAT can provide biventricular cardiac support and has the potential for clinical application.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Reproductive Biology
Zhi Ma, Mirjana Kessler, Anca Chelariu-Raicu, Markus Sperandio, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: The expression of sLeX in the receptive endometrium is enhanced by IL-1 beta, facilitating trophoblast adhesion during embryo implantation. This study provides important insights into the molecular mechanisms of embryo implantation.
BIOLOGY OF REPRODUCTION
(2023)
Review
Cell Biology
Sarajo K. Mohanta, Changjun Yin, Christian Weber, Andreas J. R. Habenicht
Summary: Two pairs of biological systems, namely the nervous and vascular systems, and the nervous and immune systems, have been defined as major participants in the regulation of physiological and pathological tissue reactions. The interactions between these systems have led to the concepts of neurovascular link and neuroimmunology. Recent studies on atherosclerosis have proposed the concept of neuroimmune cardiovascular interfaces (NICIs), which involve complex crosstalks between the nervous system, immune system, and cardiovascular system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emiel P. C. van der Vorst, Sanne L. Maas, Kosta Theodorou, Linsey J. F. Peters, Han Jin, Timo Rademakers, Marion J. Gijbels, Mat Rousch, Yvonne Jansen, Christian Weber, Michael Lehrke, Corinna Lebherz, Daniela Yildiz, Andreas Ludwig, Jacob F. Bentzon, Erik A. L. Biessen, Marjo M. P. C. Donners
Summary: This study demonstrates that endothelial ADAM10 plays a protective role in the development of murine atherosclerosis, primarily by limiting inflammation induced by oxidized low-density lipoprotein (oxLDL). The findings provide novel opportunities for treating atherosclerosis progression, but caution should be exercised when considering the use of ADAM10 inhibitors for therapy in other diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sarajo K. K. Mohanta, Changjun Yin, Christian Weber, Cristina Godinho-Silva, Henrique Veiga-Fernandes, Qian J. J. Xu, Rui B. B. Chang, Andreas J. R. Habenicht
Summary: The cardiovascular system is connected to the brain through complex axonal connections. Two distinct subcircuits, the artery-brain circuit and the heart-brain circuit, have recently been defined. The impact of the nervous system on the progression of cardiovascular disease is not well understood. This review explores the anatomy and inner workings of these subcircuits and discusses the possibility of a systemic cardiovascular brain circuit.
CIRCULATION RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Christian Weber, Andreas J. R. Habenicht, Philipp von Hundelshausen
Summary: This review summarizes recent progress in the therapeutic targeting of inflammatory components in atherosclerosis. Novel strategies, such as interference with the CD40L-CD40 dyad and selective targeting of TRAFs, show potential in reducing atherosclerosis and plaque instability without immune side effects. Additionally, modulation of the chemokine system and disruption of the adventitial neuroimmune cardiovascular interfaces offer promising avenues for intervention beyond anti-inflammatory approaches.
EUROPEAN HEART JOURNAL
(2023)
Article
Immunology
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli, Almudena Ortega-Gomez, Tommy Regen, Rachit Badolia, Valeriana Cesarini, Claudia Garcia-Gonzalez, Raphael Chevre, Giorgia Ciliberti, Carlos Silvestre-Roig, Maurizio Martini, Jedrzej Hoffmann, Rana Hamouche, Joseph R. Visker, Nikolaos Diakos, Astrid Wietelmann, Domenico Alessandro Silvestris, Georgio Georgiopoulos, Ali Moshfegh, Andre Schneider, Wei Chan, Stefan Guenther, Johanne Backs, Shin Kwak, Craig H. Selzman, Kimon Stamatelopoulos, Stefan Rose-John, Christian Trautwein, Ioakim Spyridopoulos, Thomas Braun, Ari Waisman, Angela Gallo, Stavros G. Drakos, Stefanie Dimmeler, Markus Sperandio, Oliver Soehnlein, Konstantinos Stellos
Summary: RNA editor ADAR2 regulates endothelial responses to IL-6, controlling leukocyte trafficking in inflamed and ischemic tissues. ADAR2 is required for IL-6 trans-signaling and immune cell infiltration through suppressing primary microRNA processing.
Review
Medicine, General & Internal
Sebastian Sitaru, Agnes Budke, Riccardo Bertini, Markus Sperandio
Summary: Mounting experimental evidence suggests that the CXCL8-CXCR1/2 axis plays an essential role in neutrophils in the pathophysiology of inflammatory, autoimmune, and neoplastic diseases. Therapeutic targeting of CXCR1/2 or CXCL8 has been extensively studied using in vitro and animal disease models, showing potential benefits for patients with unwanted neutrophil-mediated inflammation. However, careful evaluation is needed for the use of inhibitors in severe infections or sepsis. Inhibition of the CXCL8-CXCR1/2 axis also holds promise for cancer therapy, with ongoing efforts to define its involvement in neoplastic diseases.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Allergy
Selina K. Jorch, Annika McNally, Philipp Berger, Jonas Wolf, Kim Kaiser, Andrian Chetrusca Covash, Stefanie Robeck, Isabell Pastau, Olesja Fehler, Saskia-L. Jauch-Speer, Sven Hermann, Michael Schafers, Hanne Van Gorp, Apurva Kanneganti, Joke Dehoorne, Filomeen Haerynck, Federica Penco, Marco Gattorno, Jae Jin Chae, Paul Kubes, Mohamed Lamkanfi, Andy Wullaert, Markus Sperandio, Thomas Vogl, Johannes Roth, Judith Austermann
Summary: This study provides evidence that S100A8/A9 alarmins are released through a pyrin/caspase-1/gasdermin D-dependent pathway in FMF patients, and they directly drive autoimmune inflammation in vivo.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Anna B. Meier, Dorota Zawada, Maria Teresa De Angelis, Laura D. Martens, Gianluca Santamaria, Sophie Zengerle, Monika Nowak-Imialek, Jessica Kornherr, Fangfang Zhang, Qinghai Tian, Cordula M. Wolf, Christian Kupatt, Makoto Sahara, Peter Lipp, Fabian J. Theis, Julien Gagneur, Alexander Goedel, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Summary: The lineage of human epicardium was studied through time course single-cell analysis of epicardioids. The mesothelial envelope of the vertebrate heart, known as the epicardium, serves as the source of multiple cardiac cell lineages during embryonic development and is essential for myocardial growth and repair. Using self-organizing human pluripotent stem cell-derived epicardioids, researchers were able to observe the morphological, molecular, and functional patterning of the epicardium and myocardium, similar to the left ventricular wall. This study provides insights into the specification and differentiation process of different cell lineages in epicardioids, as well as the functional cross-talk between different cardiac cell types.
NATURE BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Sachs, Anna Goetz, Brian Finan, Annette Feuchtinger, Richard D. DiMarchi, Yvonne Doering, Christian Weber, Matthias H. Tschoep, Timo D. Mueller, Susanna M. Hofmann
Summary: Long-acting acylated GIP analog (acyl-GIP) treatment can improve dyslipidemia and atherosclerosis independently of body weight loss. This treatment may improve dyslipidemia by directly modulating lipid metabolism in the inguinal fat depot.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Frederike Boos, James A. Oo, Timothy Warwick, Stefan Guenther, Judit Izquierdo Ponce, Melina Lopez, Diba Rafii, Giulia Buchmann, Minh Duc Pham, Zahraa S. Msheik, Tianfu Li, Sandra Seredinski, Shaza Haydar, Sepide Kashefiolasl, Karl H. Plate, Ruediger Behr, Matthias Mietsch, Jaya Krishnan, Soni S. Pullamsetti, Sofia-Iris Bibli, Rabea Hinkel, Andrew H. Baker, Reinier A. Boon, Marcel H. Schulz, Ilka Wittig, Francis J. Miller, Ralf P. Brandes, Matthias S. Leisegang
Summary: Long non-coding RNA LINC00607 is highly enriched in human endothelial cells and plays a regulatory role in angiogenesis by interacting with chromatin remodeler BRG1 to maintain ERG target gene transcription. Knockdown or knockout of LINC00607 attenuates VEGF-A-induced angiogenic sprouting and integration into vascular networks. Overexpression of LINC00607 restores normal endothelial function. These findings provide new insights into the role of lncRNAs in endothelial cells and their potential implications in cardiovascular disease.
BASIC RESEARCH IN CARDIOLOGY
(2023)
