Article
Rheumatology
Chien-Chih Wang, Chin-Tien Wang, Kun-Ling Tsai, Chen-Liang Chou, Jian-Kang Chao, Hsin-Yi Huang, Chung-Lan Kao
Summary: The study showed that increased suprapatellar effusion detected by ultrasound may predict reduced efficacy of HA injection in treating knee OA.
Article
Chemistry, Medicinal
Chien-Chih Wang, Tsung-Ming Hu, Chien-Lung Chen, Chung-Chih Hong, Yu-Hui Chang, Chung-Lan Kao
Summary: We investigated the effects of hyaluronic acid (HA) injections on synovitis in knee osteoarthritis (OA). Our findings suggest that two ultrasound-guided HA injections following fluid drainage improved pain and knee function but did not significantly influence imaging-detected synovitis in patients with knee OA.
Article
Multidisciplinary Sciences
Natalia Valdrighi, Arjen B. Blom, Henk M. van Beuningen, Elly L. Vitters, Monique M. Helsen, Birgitte Walgreen, Peter L. E. M. van Lent, Marije I. Koenders, Peter M. van der Kraan, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson
Summary: This study investigated the role of sex in joint pain in the collagenase-induced OA (CiOA) model and its link with joint pathology. The results showed that sex is a determinant in the association between pain-related behavior and OA features. Therefore, segregating data analysis by sex is crucial in accurately interpreting pain data.
Article
Radiology, Nuclear Medicine & Medical Imaging
Carla du Toit, Robert Dima, Samuel Papernick, Melanie Jonnalagadda, David Tessier, Aaron Fenster, Emily Lalone
Summary: In this study, a novel application of 3-D ultrasound (3-D US) was developed to monitor soft-tissue characteristics of osteoarthritis (OA) in the carpometacarpal (CMC1) joint of the thumb. The results demonstrated that 3-D US can provide accurate and precise CMC1 synovial tissue volume measurements similar to MRI.
Article
Rheumatology
Alexander J. Knights, Easton C. Farrell, Olivia M. Ellis, Lindsey Lammlin, Lucas M. Junginger, Phillip M. Rzeczycki, Rachel F. Bergman, Rida Pervez, Monique Cruz, Eleanor Knight, Dennis Farmer, Alexa A. Samani, Chia-Lung Wu, Kurt D. Hankenson, Tristan Maerz
Summary: Through studying a PTOA mouse model, we found that synovial fibroblasts assume distinct functional identities during PTOA, and Prg4(hi) lining fibroblasts secrete Rspo2 that may drive pathological joint crosstalk after injury.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
X. Wang, T. Chen, W. Liang, T. Fan, Z. Zhu, P. Cao, G. Ruan, Y. Zhang, S. Chen, Q. Wang, S. Li, Y. Huang, M. Zeng, D. J. Hunter, J. Li, C. Ding
Summary: Subchondral bone marrow lesions (BMLs) and synovitis are important sources of pain in knee osteoarthritis (KOA), and this study found that synovitis partially mediates the relationship between BMLs and knee pain.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Endocrinology & Metabolism
Asim Ghouri, Philip G. Conaghan
Summary: Osteoarthritis is a chronic, debilitating disease that affects millions of people worldwide, and management involves both pharmacological and non-pharmacological approaches. Traditional pharmacological treatments have limited efficacy and come with side effects, leading to the need for new therapies. Disease-modifying osteoarthritis drugs (DMOADs) show promise in improving OA symptoms.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Rheumatology
Fraser L. Collins, Anke J. Roelofs, Rebecca A. Symons, Karolina Kania, Ewan Campbell, Elaina S. R. Collie-duguid, Anna H. K. Riemen, Susan M. Clark, Cosimo De Bari
Summary: This study provides a detailed characterization of synovial fibroblasts and progenitors in mouse knees, both in healthy and injured conditions. The findings shed light on the cellular and molecular principles underlying the organization and maintenance of adult synovial joints.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Xiaotian Yang, Christian S. Thudium, Anne-Christine Bay-Jensen, Morten A. Karsdal, James van Santen, Nigel K. Arden, Thomas A. Perry, Stefan Kluzek
Summary: This study found that MRI-defined medial perimeniscal and suprapatellar synovitis were positively associated with knee symptoms in established painful radiographic KOA, while serum-based C3M and CRPM markers were negatively associated with knee symptoms.
Review
Medicine, General & Internal
Katerina Laskari, Elias Siores, Maria M. Tektonidou, Petros P. Sfikakis
Summary: The ability of microwave radiometry (MWR) to accurately detect in-depth temperature changes in human tissues is being investigated for its application in the diagnosis and monitoring of inflammatory arthritis. Studies have shown promising results, suggesting that MWR can be a useful tool for the differential diagnosis of arthritis and for assessing inflammation at both joint and patient levels. However, further studies with larger patient populations are needed to confirm these findings and overcome the current limitations of MWR devices.
Article
Cell & Tissue Engineering
Zhuoxuan Jia, Bijun Kang, Yizuo Cai, Chingyu Chen, Zheyuan Yu, Wei Li, Wenjie Zhang
Summary: The study found that CEFFE (a cell-free fat extract containing multiple cytokines) inhibits the progression of osteoarthritis by promoting cartilage regeneration and limiting joint inflammation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Hui Teng, Sijia Chen, Kaijian Fan, Qishan Wang, Bingxin Xu, Di Chen, Futao Zhao, Tingyu Wang
Summary: This study investigated the effects and mechanisms of dexamethasone liposome (Dex-Lips) on osteoarthritis (OA) in miR-204/-211-deficient mice. Dex-Lips alleviated OA symptoms, reduced pain and inflammation, regulated PGE2, and repolarized synovial macrophages to M2 phenotypes.
MOLECULAR PHARMACEUTICS
(2023)
Review
Orthopedics
Daichi Hayashi, Frank W. Roemer, Mohamed Jarraya, Ali Guermazi
Summary: Synovitis is an important component of osteoarthritis and can be assessed using MRI and ultrasound. Contrast-enhanced MRI, particularly dynamic CEMRI, is the ideal method for synovitis assessment, but is not commonly performed for osteoarthritis imaging. Non-contrast-enhanced MRI can use effusion-synovitis and Hoffa-synovitis as surrogate markers for synovitis. Both MRI and ultrasound can be used to evaluate synovitis and assess the efficacy of disease-modifying approaches. Other imaging modalities such as CT and nuclear medicine imaging have limited roles in synovitis assessment. More research is needed before non-contrast-enhanced MRI can be relied upon for synovitis evaluation.
SKELETAL RADIOLOGY
(2023)
Article
Rheumatology
D. F. Pereira, J. Natour, L. H. C. Ribeiro, F. B. M. D. Ferreira, A. R. C. Fernandes, R. N. V. Furtado
Summary: In this study, it was found that in female patients with longstanding rheumatoid arthritis, painless synovitis and painful synovitis progressed similarly over a year in terms of bone erosion, ultrasound inflammatory measurements, radiographic findings, clinical worsening, and change of treatment.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Ze Gong, Shengfa Li, Peihua Cao, Guangfeng Ruan, Yan Zhang, Qing Zeng, Zijun He, Shilin Li, Rong Chen, Peng Zheng, Tao Fan, Pengcheng Lu, Yijin Zhao, Martin Englund, Henning Madry, Guozhi Huang, Le Li, Jia Li, Changhai Ding
Summary: This study aimed to investigate the association between quadriceps strength and synovitis in knee osteoarthritis (KOA). Data from the Osteoarthritis Initiative (OAI) were analyzed, including participants with or at risk of KOA. Quadriceps strength was measured, and effusion-synovitis and Hoffa-synovitis were assessed using MRI. Generalized estimating equations were used to analyze the associations.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Holly T. Philpott, Trevor B. Birmingham, Robert Dima, Ryan Pinto, Dianne Bryant, C. Thomas Appleton
Summary: The study assessed the reliability and sensitivity to change of musculoskeletal ultrasound measures in patients with knee osteoarthritis. The findings indicated moderate reliability and low-to-moderate sensitivity to change of ultrasound measures of inflammation, while the associations with pain scores over time were weak.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Ryan F. F. Pinto, Trevor B. B. Birmingham, Holly T. T. Philpott, Codie A. A. Primeau, Kristyn M. M. Leitch, Dominique A. A. Arsenault, C. Thomas Appleton
Summary: This study aimed to compare the effects of reducing knee inflammation on gait biomechanics and strength in patients with knee osteoarthritis (OA). The results showed improvements in knee inflammation, gait biomechanics, and strength after knee aspiration and glucocorticoid injection. The changes in knee biomechanics and strength were associated with reduced inflammation and pain.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Multidisciplinary Sciences
Arundhasa Chandrabalan, Andrew Firth, Robert B. Litchfield, C. Thomas Appleton, Alan Getgood, Rithwik Ramachandran
Summary: Osteoarthritis (OA) is a common joint disorder with increasing incidence worldwide. There is currently no disease-modifying treatment for OA. Protease activity and inflammation play a role in the degradation of cartilage in OA. Protease-Activated Receptors (PARs), a family of G protein-coupled receptors, are involved in triggering inflammation. This study identified the enzymes that activate PARs in knee joint synovial fluids from OA patients and healthy individuals and found that serine proteinases and matrix metalloproteinases are the major classes of PAR activating enzymes in OA synovial fluids. The elevation of PAR1 cleavage suggests that targeting this receptor may be beneficial in OA treatment.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Luigi Del Sordo, Garth B. Blackler, Holly T. Philpott, Jared Riviere, Lakshman Gunaratnam, Bryan Heit, C. Thomas Appleton
Summary: This study aimed to evaluate the burden of apoptotic cells in synovial tissue in patients with late-stage knee osteoarthritis (OA) and investigate the impairment of macrophage-mediated clearance of apoptotic cells. Results showed that patients with late-stage knee OA had higher apoptotic synovial cell burden and reduced efferocytosis activity of synovial tissue macrophages. Blood-derived macrophages exposed to synovial fluid from knee OA patients also exhibited impaired efferocytosis. Therefore, OA impairs the critical homeostatic functions of synovial macrophages, leading to accumulation of apoptotic cells.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Orthopedics
Holly T. Philpott, Garth Blackler, Joseph Daniel Klapak, Kyle K. Pitchers, Madison Tomlinson, Niall Smith, Jaclyn Viehweger, Joseph U. Umoh, David W. Holdsworth, Tristan Maerz, Christopher Thomas Appleton
Summary: Contrasting pain patterns in rat models of experimental knee osteoarthritis (OA) exposed to different OA-inducing risk factors including acute joint trauma, chronic instability, or obesity/metabolic syndrome revealed that OA risk factors influenced pain experiences differently, which hampers the translatability of preclinical OA pain research to clinical contexts.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Rheumatology
Codie A. Primeau, Trevor B. Birmingham, C. Thomas Appleton, Kristyn M. Leitch, Peter J. Fowler, Jacquelyn D. Marsh, J. Robert Giffin
Summary: This study evaluated the proportion of patients meeting responder criteria after two years of medial opening wedge HTO and investigated predictors of response. The results showed that 78% of patients met the responder criteria at 2 years postsurgery. Older age, higher BMI, and larger postoperative mechanical axis angles were associated with increased odds of achieving responder criteria. When stratified by sex, 78% of male patients and 76% of female patients met the responder criteria.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Codie A. Primeau, Holly T. Philpott, Kyle Vader, Janelle Unger, Christina Y. Le, Trevor B. Birmingham, Joy C. Macdermid
Summary: Entry-level physiotherapy students in Canada have positive attitudes towards working with 2SLGBTQIA + individuals, but they believe their physiotherapy programs lack sufficient knowledge and inclusiveness regarding this population, indicating a need for greater attention and training in 2SLGBTQIA + health.
Article
Rehabilitation
Kestrel McNeill, Hana Marmura, Melanie Werstine, Greg Alcock, Trevor Birmingham, Kevin Willits, Alan Getgood, Marie-Eve Lebel, Robert Litchfield, Dianne Bryant, J. Robert Giffin
Summary: A staged approach to ACLR rehabilitation does not seem to hinder knee function at 6 months postoperative, but it may result in poorer patient-reported outcomes in the early follow-ups.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Education & Educational Research
Codie A. A. Primeau, Holly T. T. Philpott, Kyle Vader, Janelle Unger, Christina Y. Y. Le, Trevor B. B. Birmingham, Joy C. C. MacDermid
Summary: Entry-level physiotherapy students in Canada lack understanding and awareness of 2SLGBTQIA+ health and inclusive behaviors, which can impact patient experience. Students report feeling incompetent when working with 2SLGBTQIA+ patients, potentially due to inadequate training. Greater efforts and attention are needed to increase 2SLGBTQIA+ health education and inclusivity in Canadian entry-level physiotherapy programs.
BMC MEDICAL EDUCATION
(2023)
Meeting Abstract
Orthopedics
A. Mahmoudian, L. K. King, J. W. Liew, Q. Wang, C. T. Appleton, M. Englund, I. K. Haugen, L. S. Lohmander, J. Runhaar, A. Turkiewicz, T. Neogi, G. Hawker
OSTEOARTHRITIS AND CARTILAGE
(2023)
Meeting Abstract
Orthopedics
T. A. Perry, Y. Deng, P. Hulley, R. A. Maciewicz, J. Mitchelmore, D. Perry, S. Larsson, S. Lemire, A. Struglics, C. T. Appleton, S. Kluzek, N. K. Arden, D. T. Felson, B. Marsden, B. D. Tom, L. Bondi, M. Kapoor, V. Kumar, L. S. Lohmander, T. J. Welting, D. A. Walsh, A. M. Valdes, L. Jostins-Dean, F. E. Watt, T. L. Vincent
OSTEOARTHRITIS AND CARTILAGE
(2023)
Meeting Abstract
Orthopedics
L. K. King, A. Mahmoudian, E. J. Waugh, C. MacKay, I. Stanaitis, J. W. Liew, Q. Wang, A. Turkiewicz, I. K. Haugen, C. T. Appleton, S. Lohmander, M. Englund, J. Runhaar, T. Neogi, G. A. Hawker
OSTEOARTHRITIS AND CARTILAGE
(2023)