Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 22, Pages 16059-16067Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01271
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Funding
- National Natural Science Foundation of China [21602078]
- Pearl River Talent Program of Guangdong Province (Youth Top-Notch Talent) [2017GC010302]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011743]
- Jinan University
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A practical protocol for synthesizing 3-substituent-2-(azol-1-yl)indole derivatives has been developed through an electrochemical oxidative cross coupling process. This strategy tolerates a variety of functional groups and is suitable for gram scale synthesis, as well as late-stage functionalization of bioactive molecules.
A practical protocol to synthesize 3-substituent-2-(azol-1-yl)indole derivatives has been developed via an electrochemical oxidative cross coupling process under mild conditions. This electro-oxidative C-N bond formation strategy tolerates a range of functional groups and is amenable to gram scale synthesis. Moreover, this method was applied to the late-stage functionalization of bioactive molecules.
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