Investigation of molecular interactions of a drug Isoprenaline Hydrochloride-L-alanine in water at different temperatures

Studies of volumetric and compressibility properties of aqueous solutions of medicinal compounds are essential for understanding the molecular interactions between the drug and solvent molecules. In this regard, we have measured the density and speed of sound data for the drug i.e. isoprenaline hydrochloride in aqueous medium and in 0.05 mol.kg(-1) aqueous L-alanine solution within the molality range (0.05-0.12 mol.kg(-1)) at different temperatures i.e. T = 293.15, 298.15, 303.15, 308.15 and 313.15 K. This data have been used to obtain the apparent molar volume of solute (V-phi), isentropic compressibility (kappa(S)) of solutions and apparent molar isentropic compressibility of solute K-S phi as a function of concentration of the drug. The temperature variation data enabled us to calculate apparent molar expansivity E-phi and limiting expansivity at infinitely dilute solutions (E-phi(0)) at selected temperatures. The results are discussed in terms of ion-solvent interactions in binary solutions and the effect of addition of amino acid on the similar interactions. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study measured the properties of two medicinal compounds in aqueous solutions, and investigated how the volume and compressibility of the solutes change with concentration and temperature, as well as the effect of amino acids on the solution properties.