Lipoprotein compartmentalisation as a regulator of PCSK9 activity

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

(2020) Samantha K. Sarkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Density Lipoproteins Are the Main Carriers of PCSK9 in the Circulation

(2020) Sean A. Burnap et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PCSK9

(2018) Michael D. Shapiro et al.   CIRCULATION RESEARCH

Relationship between “LDL-C”, estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide

(2018) Nicholas J. Viney et al.   Journal of Clinical Lipidology

PCSK9 Association With Lipoprotein(a)Novelty and Significance

(2016) Hagai Tavori et al.   CIRCULATION RESEARCH

Effects of lipoprotein apheresis on PCSK9 levels

(2015) U. Julius et al.   ATHEROSCLEROSIS SUPPLEMENTS

Removal of Plasma Mature and Furin-Cleaved Proprotein Convertase Subtilisin/Kexin 9 by Low-Density Lipoprotein-Apheresis in Familial Hypercholesterolemia: Development and Application of a New Assay for PCSK9

(2015) Mika Hori et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clearance of Plasma Proprotein Convertase Subtilisin/Kexin 9 by Low-Density Lipoprotein Apheresis

(2014) P.B. Duell et al.   CIRCULATION RESEARCH

Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Cell Surface Low-Density Lipoprotein Receptor

(2013) Hagai Tavori et al.   CIRCULATION

Loss of Plasma Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) After Lipoprotein Apheresis

(2013) Hagai Tavori et al.   CIRCULATION RESEARCH

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

(2013) Tanja Kosenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor–independent pathways

(2012) Jamie Cameron et al.   Translational Research

LDL-apheresis depletes apoE-HDL and pre-β1-HDL in familial hypercholesterolemia: relevance to atheroprotection

(2011) Alexina Orsoni et al.   JOURNAL OF LIPID RESEARCH

Genetic and Metabolic Determinants of Plasma PCSK9 Levels

(2009) Susan G. Lakoski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Self-Association of Human PCSK9 Correlates with Its LDLR-Degrading Activity†

(2008) Daping Fan et al.   BIOCHEMISTRY