In-hospital mortality in SARS-CoV-2 stratified by serum 25-hydroxy-vitamin D levels: A retrospective study

This study is done to estimate in-hospital mortality in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stratified by Vitamin-D (Vit-D) levels. Patients were stratified according to by serum 25-hydroxy-vitamin D (25(OH)Vit-D) levels into two groups, that is, 25(OH)Vit-D less than 40 nmol/L and 25(OH)Vit-D greater than 40 nmol/L. A total of 231 patients were included. Of these, 120 (50.2%) of the patients had 25(OH)Vit-D levels greater than 40 nmol/L. The mean age was 49 +/- 17 years, and 67% of the patients were males. The median length of overall hospital stay was 18 [6; 53] days. The remaining 119 (49.8%) patients had a 25(OH)Vit-D less than 40 nmol/L. Vitamin D levels were seen as deficient in 63% of patients, insufficient in 25% and normal in 12%. Overall mortality was 17 patients (7.1%) but statistically not significant among the groups (p = 0.986). The Kaplan-Meier survival analysis showed no significance based on an alpha of 0.05, LL = 0.36, df = 1, p = 0.548, indicating Vitamin_D_Levels was not able to adequately predict the hazard of Mortality. In this study, serum 25(OH)Vit-D levels were found have no significance in terms of predicting the in-hospital mortality in patients with SARS-CoV-2.

Automated summary

This study found that serum 25(OH)Vit-D levels were not significantly associated with predicting in-hospital mortality in patients with SARS-CoV-2.