PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high fat diet conditions

Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl4 in mice

(2020) Min Sha et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells

(2020) Luigi Sapio et al.   Journal of Oncology

AdipoRon improves cognitive dysfunction of Alzheimer’s disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway

(2020) Bin Liu et al.   EXPERIMENTAL NEUROLOGY

An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress

(2019) Amy Botta et al.   Nutrition & Metabolism

Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease

(2019) Yaeni Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AdipoRon Protects Against Secondary Brain Injury After Intracerebral Hemorrhage via Alleviating Mitochondrial Dysfunction: Possible Involvement of AdipoR1–AMPK–PGC1α Pathway

(2019) Jun Yu et al.   NEUROCHEMICAL RESEARCH

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

(2019) Amit Lalwani et al.   Cell Reports

Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells

(2019) Amin A. Ramzan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS‐1 pancreatic β cells

(2019) Yan Wang et al.   CELL BIOCHEMISTRY AND FUNCTION

Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice

(2019) Wen-Ze Xiao et al.   CHINESE MEDICAL JOURNAL

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes

(2018) Yaeni Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy

(2018) Sun Ryoung Choi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis

(2018) Takashi Yamashita et al.   Scientific Reports

Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression

(2018) Sarah Nicolas et al.   Translational Psychiatry

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload

(2018) Ning Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Structural insights into adiponectin receptors suggest ceramidase activity

(2017) Ieva Vasiliauskaité-Brooks et al.   NATURE

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

(2017) Katrin Fischer et al.   NATURE MEDICINE

AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia

(2017) Arwa Fairaq et al.   PHARMACOLOGICAL RESEARCH

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

(2017) Fanuel Messaggio et al.   Oncotarget

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

(2017) Leonore Wigger et al.   Cell Reports

Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

(2017) William L. Holland et al.   Molecular Metabolism

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice

(2016) Ying Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion

(2015) Daliang Li et al.   ACS Chemical Biology

AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings

(2015) Yanqing Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults

(2015) Aviroop Biswas et al.   ANNALS OF INTERNAL MEDICINE

GLP-1 Receptor Mediated Targeting of a Fluorescent Zn2+ Sensor to Beta Cell Surface for Imaging Insulin/Zn2+ Release

(2015) Daliang Li et al.   BIOCONJUGATE CHEMISTRY

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

Palmitate-Induced Impairments of β-Cell Function Are Linked With Generation of Specific Ceramide Species via Acylation of Sphingosine

(2015) Levon Manukyan et al.   ENDOCRINOLOGY

Adiponectin-Mediated Antilipotoxic Effects in Regenerating Pancreatic Islets

(2015) Risheng Ye et al.   ENDOCRINOLOGY

The Paradoxical Effects of AMPK on Insulin Gene Expression and Glucose-Induced Insulin Secretion

(2015) Ji-Won Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Accumulation of adiponectin in inflamed adipose tissues of obese mice

(2014) Hideaki Nakatsuji et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

(2014) Risheng Ye et al.   eLife

Regulation of glucose and lipid homeostasis by adiponectin: Effects on hepatocytes, pancreatic β cells and adipocytes

(2013) Caroline Tao et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

(2013) Toshimasa Yamauchi et al.   Cell Metabolism

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Adiponectin and energy homeostasis

(2013) Bonggi Lee et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Ronning After the Adiponectin Receptors

(2013) W. L. Holland et al.   SCIENCE

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

(2012) Feng Fang et al.   ARTHRITIS RESEARCH & THERAPY

Functional annotation of the human fat cell secretome

(2012) Ingrid Dahlman et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

(2011) Julia Monsénégo et al.   JOURNAL OF HEPATOLOGY

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

(2010) G. Sun et al.   DIABETOLOGIA

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

(2010) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion

(2010) Nadeeja Wijesekara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS